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This section provides an overview for single cell analyses as well as their applications and principles. Also, please take a look at the list of 19 single cell analysis manufacturers and their company rankings. Here are the top-ranked single cell analysis companies as of December, 2024: 1.Global Life Sciences Solutions USA LLC, 2.Namocell, 3.RareCyte, Inc..
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Recent advances in genome analysis technology have revealed that even seemingly homogeneous cell populations are actually heterogeneous when individual cells are isolated and analyzed. Single cell analysis provides insights into the unique characteristics of individual cells, leading to significant applications in fields like cancer research, immunology, and drug discovery. This approach allows for the exploration of cellular responses at an individual level, moving beyond the average values obtained from traditional population-based genetic analysis.
Single-cell separation can be done manually, but this method has a low throughput. For high-throughput processing, microfluidics is used to trap cells in chambers that can hold only one cell. However, the number of cells that can be trapped is limited by the plate area used to create the trap, usually capping at a few hundred cells. To process a larger number of cells, droplet-based cell separation systems have recently become the standard.
In droplet-based systems, fluorinated oil is used as the continuous phase, with hydrogel or lysis buffer as the dispersed phase. This setup enables the encapsulation of a single cell within each droplet, creating thousands of droplets per second. Hydrogel encapsulation is particularly useful for 3D culture, cellular response studies, and FACS, while encapsulation with specialized barcode beads is employed for mRNA capture and gene expression analysis.
The droplet-based method involves creating droplets at a junction point in a microfluidic channel. This is achieved by pumping a cell suspension, cell lysate, and fluorinated oil. The cell suspension and lysate are mixed just before encapsulation, ensuring that cells are lysed within the droplet. This method allows for precise and efficient single-cell encapsulation, facilitating detailed cellular analysis.
*Including some distributors, etc.
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Illumina, Inc., founded in 1998, and headquartered in San Diego, California, is a manufacturer of research equipment for cancer research, biomarker recovery, molecular diagnostics & disease association applications. Its product range includes sequencing instruments, microarray kits, molecular biology reagents, in vitro diagnostic (IVD) products, software and services, catering to industries such as pharmaceutical, academic, clinical, and forensics. Its products are used for DNA analysis, facilitating gene expression studies, aiding in genetic research, and for medical testing and diagnostics.
PacBio is a manufacturer in the biotechnology sector based in California, USA. Founded in 2004, the company specializes in manufacturing DNA sequencing platforms. One of its notable offerings is the Revio DNA Sequencing System. This product represents a pinnacle of genetic analysis technology, designed to cater to the needs of researchers, scientists, and professionals seeking insights into DNA sequences. Researchers benefit from the ability to uncover intricate genetic variations, structural arrangements, and epigenetic modifications with accuracy. The company's clientele comprises a diverse array of stakeholders in the scientific and research communities.
NanoString Technologies, Inc., established in 2003 and based in Seattle, WA, USA, is a manufacturer and supplier of life science tools for translational research. The company's product range includes the nCounter Analysis System, GeoMx Digital Spatial Profiler, CosMx Spatial Molecular Imager, and Digital Molecular Barcoding technology. These products assist in gene and protein expression analysis, spatial profiling, and in situ tissue analysis at cellular resolution. They serve industries based on gene expression, miRNA, CNV, and single-cell analysis. The company provides digital genomics for pathway-based research, and multiplexed molecular diagnostic development.
Advanced Cell Diagnostics Inc., established in 2007, is a biotechnology research company based in Newark, United States. The company specializes in molecular pathology and conducts cell and tissue research and diagnostic tests for personalized medicine. Its catalog includes ISO-CERTIFIED products like target probes, RNAscope Fluorescent Multiplex Assay, automated assay Leica and DNAscope assay. The company also has a portfolio of services such as biomarker assay development, gene therapy, tissue bank and sample procurement.
Yokogawa Test & Measurement Corporation was founded in Japan in 1954. Yokogawa currently serves a wide array of industries including the aerospace, automotive, consumer electronics, semiconductor and telecommunications industries with both hardware and software solutions. Among Yokogawa’s suite of products are oscilloscopes, voltage probes, power analyzers and meters, data acquisition tools, optical test equipment, a wide variety of handled meters, calibrators, and testers; analog instruments, and manometers.
Takara Bio Inc., established in 1925, is a manufacturer and distributor of life science reagents based in Shiga, Japan. The company's service portfolio includes sequencing, stem cell research, gene function, cloning and PCR applied in vaccine development, reproductive health, molecular diagnostics, cancer research and pathogen detection. Takara Bio’s products fall under three brands, namely Takara, Clontech and Cellartis, each with its area of expertise. The company also offers research classes through webinars, technical notes and other informational resources and has business operations in the USA, China, Korea, Europe and India.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Global Life Sciences Solutions USA LLC |
9.6%
|
| 2 | Namocell |
8.4%
|
| 3 | RareCyte, Inc. |
7.2%
|
| 4 | Mission Bio, Inc. |
6.6%
|
| 5 | PacBio |
6.3%
|
| 6 | CYTENA GmbH |
6.0%
|
| 7 | Parse Biosciences |
6.0%
|
| 8 | Precigenome LLC |
5.7%
|
| 9 | MedGenome Inc. |
5.4%
|
| 10 | Takara Bio Inc. |
5.1%
|
Derivation Method
The ranking is calculated based on the click share within the single cell analysis page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
12 | 70.6% |
|
Japan
|
2 | 11.8% |
Germany
|
1 | 5.9% |
Sweden
|
1 | 5.9% |
France
|
1 | 5.9% |
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