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This section provides an overview for microspectrophotometers as well as their applications and principles. Also, please take a look at the list of 12 microspectrophotometer manufacturers and their company rankings. Here are the top-ranked microspectrophotometer companies as of January, 2025: 1.Hercuvan Lab Systems, 2.NINGBO HINOTEK INSTRUMENT CO.,LTD, 3.Angstrom Sun Technologies Inc..
Table of Contents
A microspectrophotometer is a spectrophotometer specialized for the measurement of very small amounts of samples.
Like the spectrophotometer, it is intended for quantitative analysis to determine the concentration of specific substances in a sample. It can analyze the amount of DNA, protein, and other substances contained in a sample, and is widely used in the life science field.
The instruments themselves are compact and easy to handle, and models with touch panels and models that can easily output data externally are also available.
The main application of microspectrophotometers is the determination of DNA, RNA, oligonucleic acids, and proteins from extremely small amounts of samples. They are mainly used in research and development in the life science field.
The quantification and purity evaluation of nucleic acids and proteins is a necessary process in genomic DNA preparation, RT-qPCR, and sample quality control. Kinetic evaluation is also performed by monitoring bacterial culture growth and measuring over time.
The basic principle of the microspectrophotometer is the same as that of the Spectrophotometer. The spectrophotometer quantifies the concentration of a particular substance in a sample based on how much light shined on the sample reaches through it. The higher the concentration, the lower the transmission because light is blocked by substances dissolved in the sample.
A spectrophotometer is an instrument consisting of a light source, a sample cell (such as a sample port in the case of a microspectrophotometer), and a detector. The light emitted from the light source is divided into monochromatic light using a monochromator, irradiated onto the sample, and the light that passes through the sample (transmitted light) is measured using a detector.
A calibration curve of the amount of transmitted light (absorbance) and concentration is prepared using a solution of known concentration to determine the concentration of the unknown sample.
Microspectrophotometers are generally capable of measuring very small sample volumes, but the minimum volume varies from instrument to instrument. For example, there are 0.3 µL, 0.5 µL, 1 µL, etc. It is important to select the appropriate one for the sample to be used.
On the other hand, some instruments can be used in a cell or on a cuvette board to measure samples of a certain volume. Some microspectrophotometers are also equipped with algorithms and programs to help perform advanced analyses.
For example, those equipped with programs that allow measurements over time at specific wavelengths are useful for performing kinetic analysis. Others are equipped with a reference library of spectra and impurity prediction algorithms that can predict impurities in a sample and calculate more accurate sample concentrations.
In an ordinary spectrophotometer, the sample is placed in a cell for measurement. In a microspectrophotometer, however, the sample is so small that it is generally dropped into the sample port with a pipette for measurement. Some instruments can be used for measurements other than micro amounts, and it is possible to analyze samples by placing them in a cell as in a regular microspectrophotometer, or by using a cuvette board.
In microspectrophotometers, it is often important that droplets are formed by surface tension, so each product has its mechanism to ensure proper measurement. Some instruments are also designed to confine the sample in a sealed space to reduce the risk of evaporation or contamination.
Xenon flash lamps are often used as the light source. Xenon flash lamps are characterized by high brightness and low heat generation from the lamps. This reduces damage to samples that are sensitive to temperature changes.
*Including some distributors, etc.
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Ocean Insight is the Applied Spectral Knowledge company, founded in 1989, is a manufacutring company using spectral technology, application expertise, and manufacturing scalability to help customers take on important challenges for a safer, cleaner, healthier future, headquartered in Florida, USA. The company consists of three industry brands: Ocean Optics, which pioneered miniature spectrometers and delivers spectral solutions to researchers, OEMs and industrial customers; Ocean Applied, which designs and builds industrial-grade photonics systems for material inspection, chemical identification and quality assurance; and International Light, which supplies lighting assemblies, light measurement solutions and calibration services.
CRAIC Technologies, established in 1994 and headquartered in Vancouver, British Columbia, is a manufacturer of microspectrometers. Its specialization lies in microspectrometers, UV-visible-NIR microscopes, and Raman spectrometers which are used for analyzing materials' chemical composition, structure, and morphology at micro- and nanoscales. The company also offers scientific-grade systems for industries such as semiconductor inspection and pharmaceutical metrology, alongside are NIST traceable standards, specifically designed for microspectrophotometers, as well as specialized software packages.
Thermo Fisher Scientific Inc., founded in 1956 and headquartered in Waltham, Massachusetts, is a manufacturer and supplier of life science solutions, analytical instruments, specialty diagnostics, laboratory products, and biopharma services. Through its brand names, including Invitrogen, Fisher Scientific, Patheon, Applied Biosystems, and Gibco, among others, the company provides a wide range of products, which include chromatography systems, thermal cyclers, automated cell counters, fermenters, and DNA polymerases. The company’s annual revenue is over 40 billion USD, and it serves several fields, including customers working in clinical diagnostic labs, research institutions, hospitals, government agencies, and pharmaceutical/biotech companies.
Mettler Toledo was incorporated in 1945 in Toledo, Ohio, and is today headquartered in Greifensee, Switzerland. Mettler Toledo is a manufacturer of various analytical instruments for use in laboratories, industrial and manufacturing, and food retailing applications to customers globally. Mettler Toledo offers many products across product lines for uses such as product inspection, process analytics, jewelry scales, moisture analyzers, and software for laboratory weighing. Mettler Toledo also offers numerous accessories such as density kits, hands-free accessories, weighing tables, and weight accessories.
Maxome Labsciences Pvt. Ltd., established in 2019 with headquarters in India, is a manufacturer and supplier of laboratory and analytical tools and equipment under the brand name Maxome. The company's products include single-phase roller mixers, digital microcentrifuges with timers, PPE equipment, polypropylene microcentrifuge tube boxes, and 3D rotating mixers, and it stocks over 1,000 laboratory equipment items. The company's products are used by a wide range of industries, including chemical processing, process manufacturing, building construction, governmental organizations, and educational markets.
HORIBA RADIO LABORATORY was established in Japan in 1945 and has spent the last three-quarters of a century growing as an R&D company and engaged in international operations. HORIBA Scientific offers 200 years of experience developing high-performance scientific instruments and analytical solutions. The HORIBA Group of worldwide companies provides an extensive array of instruments and systems for applications ranging from automotive R&D, process and environmental monitoring, in-vitro medical diagnostics, semiconductor manufacturing, and metrology to a broad range of scientific R&D and QC measurements. Operating in Asia, Europe, and North and South America, HORIBA scientific develops solutions that go beyond just products.
Biochrom Ltd., established in 1970 and currently a subsidiary of Harvard Bioscience Inc., is a manufacturer headquartered in Cambridge, United Kingdom, specializing in quality control instruments. The company's product range includes ultraviolet (UV) and microvolume spectrophotometers, colorimeters, and cell density meters. It also provides amino acid analyzers, organoid electrophysiology systems, as well as electroporation and electrofusion equipment. It further offers service packages, including software systems for whole-body plethysmography, resistance and compliance measurements, and inhalation towers. The company serves doctors, scientists, and technicians in hospitals and laboratories worldwide.
Angstrom Sun Technologies Inc. was established in 2002 and is headquartered in Boston, USA, is a manufacturer of optical systems & solutions for various industrial applications. The company associates with NASA Marshall Space Flight Center, National Institute of Standards and Technology, Massachusetts Institute of Technology, and Seoul National NanoTech Center, and provides spectroscopic reflectometers, micro spectrophotometers, micro reflectometers, film thickness mapping systems, and, simple desktop film thickness stations, as well as automatic variable angle spectroscopic ellipsometers, wafer & gap thickness tools, along with associated software& accessories that have applications in optometry, semiconductor, photonics, and, microsystems research arenas.
NINGBO HINOTEK INSTRUMENT CO., LTD, established in 2002 and headquartered in Ningbo, China, is a manufacturer and supplier of laboratory equipment. The company’s comprehensive product range encompasses fume hoods, incubators, ovens, centrifuges, and pH meters, serving a diverse clientele across educational institutions, hospitals, pharmaceuticals, biotechnology, and chemical industries. It offers an array of services including engineering and design, testing and certification, supply chain management, and technical support, aligning with its unwavering emphasis on customer satisfaction. The company also holds ISO 9001:2015 certification, underscoring its passion for maintaining exemplary quality standards.
Evident Corporation is a scientific research and development company in Shinjuku, Tokyo that was established in 2008. Formerly known as Olympus Scientific Solutions, the company specializes in developing cutting-edge technology and products for various industries, including aerospace, automotive, electronics, energy, and medical research. Evident Corporation has proliferated and expanded its product offerings and services to meet the needs of its customers. Their product offerings include non-destructive testing (NDT) solutions such as thickness gauges and automated inspection systems, XRF analyzers like handheld XRF analyzers, industrial microscopes, and video scopes and borescopes.
Hercuvan Lab Systems, established in 2011, is a supplier of laboratory equipment and scientific instruments. Their expertise spans development, marketing, distribution, and after-sales service. They cater to life science, biotech, research labs, and academia globally, offering advanced lab solutions such as microvolume spectrophotometers, thermal cyclers, and precision pipettes. The company's product line encompasses centrifuges, incubators, shakers, and more. Operating via a network of international distributors, Hercuvan Lab Systems ensures quality products and support for scientific advancement.
Ranking as of January 2025
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Hercuvan Lab Systems |
17.1%
|
| 2 | NINGBO HINOTEK INSTRUMENT CO.,LTD |
11.4%
|
| 3 | Angstrom Sun Technologies Inc. |
11.4%
|
| 4 | Evident |
11.4%
|
| 5 | Ocean Insight |
8.6%
|
| 6 | HORIBA |
8.6%
|
| 7 | Maxome Labsciences Pvt. Ltd. |
5.7%
|
| 8 | CRAIC Technologies |
5.7%
|
| 9 | Mettler-Toledo |
5.7%
|
| 10 | Thermo Fisher Scientific Inc. |
5.7%
|
Derivation Method
The ranking is calculated based on the click share within the microspectrophotometer page as of January 2025. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 30.0% |
|
Japan
|
3 | 30.0% |
|
Germany
|
1 | 10.0% |
|
India
|
1 | 10.0% |
|
China
|
1 | 10.0% |
|
United Kingdom
|
1 | 10.0% |
15 products found
15 products
Molecular Devices Japan Co., Ltd.
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