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This section provides an overview for spectrofluorometers as well as their applications and principles. Also, please take a look at the list of 10 spectrofluorometer manufacturers and their company rankings. Here are the top-ranked spectrofluorometer companies as of December, 2024: 1.Lumex Instruments Canada, 2.SAFAS, 3.LabGeni.
Table of Contents
A spectrofluorometer is an instrument that analyzes the light emitted from molecules and ions in a sample.
It is a type of spectrophotometer. Other types of spectrophotometers include UV/visible spectrophotometers and infrared spectrophotometers. Since the emission spectrum differs for each molecule and ion, it is possible to quantify the components contained in a sample based on the wavelength and intensity of the emission peak.
A spectrofluorometer is extremely sensitive and is used to detect trace elements. In biochemistry, it is also used to analyze the movement of proteins in living organisms by combining it with fluorescent probes that bind to specific compounds.
In samples containing multiple components, such as living organisms and foods, the luminescence of each component overlaps, resulting in complex spectra. Recently, statistical analysis methods, such as multivariate analysis, are being considered to extract information on a large number of components.
Spectrofluorometers are used to detect and quantify the smallest amounts of components in a sample. Quantitative analysis by spectrofluorometry is 1,000 times more sensitive than absorption spectrophotometry.
Specifically, they are used to measure the quantum yield, which is an indicator of the luminous efficiency of white LEDs and organic EL elements, as well as to analyze the spectrum of light emitted by the elements. Spectral analysis is extremely complex, but analysis software is becoming more sophisticated and can extract various information.
Figure 1. Principle of spectrofluorometerol
Spectrofluorometers are instruments that use fluorescence (or phosphorescence). This is the extra energy emitted as light when electrons in molecules and ions return from their excited state to their ground state. Each molecule has its own unique energy state and selectively absorbs light of a specific wavelength to transition to the excited state.
The electrons in the excited state immediately return to the ground state, emitting light with a wavelength corresponding to the difference in energy levels between the excited and ground states. If the irradiated light is not of a wavelength that is absorbed by the sample, no fluorescence is emitted and the measurement cannot be performed.
Figure 2. Spectrofluorometer and multivariate analysis
Fluorescence measurement of samples containing many organic substances, such as food, has been used to analyze the classification of patterns by origin and raw material. When a sample contains multiple components, the spectrum obtained by spectrofluorometers is the sum of the fluorescence emitted by each component.
In general, the fluorescence spectrum of a sample containing multiple components is very complex and difficult to analyze. In particular, samples containing numerous organic substances, such as food and beverages, will have many peaks, which can only be analyzed by a skilled person.
On the other hand, there have been recent attempts to obtain information from complex emission spectra of foods using multivariate analysis and statistical analysis methods. For example, principal component analysis (PCA), one of the multivariate analysis methods, can be used to compress multidimensional data such as spectra into two or three lower dimensions.
After the PCA is performed, the distribution of each sample is used for grouping analysis.
Figure 3. Utilization of spectrofluorometer
In the field of biochemistry, fluorescent probes can be selectively bound to specific proteins or calcium ions, enabling the quantification of the relevant components. For example, in the detection of calcium ions, a compound called a chelating agent, which has a structure that selectively traps ions, can be used.
Other fluorescent probes include polymers modified from fluorescent proteins derived from living organisms. These polymers are derived from fluorescent proteins, and their introduction enables them to replicate in living cells themselves.
The Nobel Prize-winning Japanese scientist Osamu Shimomura is credited with the discovery of this green fluorescent protein. The ability to introduce fluorescent proteins into biomolecules and to detect them with high sensitivity using a fluorometer has greatly advanced the analysis of biomolecules.
*Including some distributors, etc.
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StellarNet, Inc. is an American miniature spectrometer system products manufacturer and supplier that was established in Tampa, Florida, in 1991. The company’s product lineup includes portable and compact fiber optic spectrometers for near-infrared (NIR), visible (VIS), and UV measurements. It also offers various specialized light sources such as deuterium, tungsten halogen, and mercury argon. The company’s products are commonly used in academic and research institutions, as well as in the medical industry.
HORIBA RADIO LABORATORY was established in Japan in 1945 and has spent the last three-quarters of a century growing as an R&D company and engaged in international operations. HORIBA Scientific offers 200 years of experience developing high-performance scientific instruments and analytical solutions. The HORIBA Group of worldwide companies provides an extensive array of instruments and systems for applications ranging from automotive R&D, process and environmental monitoring, in-vitro medical diagnostics, semiconductor manufacturing, and metrology to a broad range of scientific R&D and QC measurements. Operating in Asia, Europe, and North and South America, HORIBA scientific develops solutions that go beyond just products.
SAFAS S.A., founded in Monaco in 1952, is a manufacturer of high-tech scientific instruments. It designs, manufactures, and markets a comprehensive portfolio of scientific instruments, including UV-Visible Spectrophotometers, Spectrofluorometers, Luminometers, and Absorption and Emission Spectrophotometers. The company can also create custom instruments, software, and accessories for specific applications, as well as offering a wide range of advanced options, such as fiber optic measurements, dewars, automatic samplers, and integrating spheres for reflectance.
Lumex Instruments Canada, headquartered in Mission, British Columbia, is a developer and manufacturer of laboratory and industrial analytical equipment, founded in 1991. Its diverse product range encompasses capillary electrophoresis systems, PCR analyzers, atomic absorption spectrometers (including mercury analyzers and monitors), FTIR and NIR spectrometers, and fluorimeters. These offerings find application across sectors such as environmental control, water treatment, agriculture, food safety, and pharmaceuticals. A significant number of its applications are developed in accordance with international standards, such as ASTM, ISO, EN and EPA.
Edinburgh Instruments was founded in 1971 and is a manufacturer of advanced molecular spectroscopy and gas detection products and is headquartered in Livingston, Scotland. The primary attention of Edinburgh Instruments lies in the design and production of customized spectroscopic systems catering to several spectroscopy markets such as Photoluminescence, Raman, UV-Vis, and Transient Absorption. The company engages in research, manufacturing, and commercializing a diverse array of goods catering to the scientific research and industrial sectors.
XiangYi Instrument (Xiangtan) Co. Ltd. was established in 2005, as a manufacturer of laboratory equipment in China. The products are categorized into different types, such as Petroleum/Oil Tester which consists of equipment like Viscometers, density, distillation, ash, and pH testers. Similarly, there is a category of Thermal Analyzers, Refrigerating and Cryogenics, Automatic Fusion machines, and incubators, along with Analyzers for water quality, particle size, surface area, and more, and various laboratory instruments and equipment that are used in schools, research units, factories, and pharmaceutical laboratories.
Shimadzu Corporation, founded in 1875 and based in Nakagyo Ward, Kyoto, is a Japanese manufacturer and supplier specializing in precision instruments, measuring instruments, and medical equipment. The company's products and solutions cater to various industries, including pharmaceuticals, environmental, and research institutions. For instance, Shimadzu produces analytical and measuring instruments like chromatographs and spectrometers, utilized for quality control as well as research and development in the environment, life science, and pharmaceutical fields. Furthermore, Shimadzu's medical products and systems aid in early disease detection and treatment, particularly for conditions like cancer. Additionally, Shimadzu supports manufacturing activities by providing vacuum equipment and industrial machinery.
JASCO Global, established in 1958, is headquartered in Tokyo, Japan, as a manufacturer of analytical apparatus utilized in academic and production research endeavors. The company functions as a provider of a diverse array of spectrometers, spectrophotometers, and liquid chromatography, as well as supercritical fluid chromatography apparatus. Jasco's extensive team of research and development (R&D) applications scientists and technical support experts have successfully developed instrumentation that meets the stringent requirements for accuracy, performance, and dependability in modern laboratory settings.
LabGeni is a manufacturer and supplier of laboratory equipment and consumables that was established in 2004 and is headquartered in Wuhan, China. LabGeni's main activity is the design, development, and manufacturing of laboratory equipment, including microplate readers, centrifuges, and incubators. The company also offers a wide range of laboratory consumables, such as pipette tips, microcentrifuge tubes, and cell culture media. Its products are used by a wide range of customers, including academic institutions, research laboratories, and pharmaceutical companies. LabGeni has over 200 employees and operates in more than 20 countries.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Lumex Instruments Canada |
19.8%
|
| 2 | SAFAS |
12.2%
|
| 3 | LabGeni |
12.2%
|
| 4 | JASCO Global |
9.2%
|
| 5 | Shimazu Corporation |
9.2%
|
| 6 | Shimadzu Seisakusho Co., Ltd. |
9.2%
|
| 7 | StellarNet, Inc. |
8.4%
|
| 8 | Edinburgh Instruments Ltd. |
7.6%
|
| 9 | XiangYi Instrument (Xiangtan) Co., Ltd. i |
6.1%
|
| 10 | HORIBA |
6.1%
|
Derivation Method
The ranking is calculated based on the click share within the spectrofluorometer page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 44.4% |
|
United States of America
|
1 | 11.1% |
| Monaco | 1 | 11.1% |
|
Canada
|
1 | 11.1% |
|
United Kingdom
|
1 | 11.1% |
|
China
|
1 | 11.1% |
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