This section provides an overview for lipid nanoparticles as well as their applications and principles. Also, please take a look at the list of 8 lipid nanoparticle manufacturers and their company rankings.
Lipid nanoparticles (LNP) are nanosized lipid nanoparticle. In pharmaceuticals, nucleic acid drugs and water-soluble drugs can be introduced into the water-soluble central part, while lipophobic drugs can be introduced into the hydrophobic part.
Lipid nanoparticles are used in drug delivery systems (DDS) to deliver drugs to target tissues by controlling the size of lipid nanoparticle or by modifying the surface of the particles with antibodies.
Pharmaceuticals are also being developed in the form of nano-gas bubbles in which medical gases are trapped inside lipid nanoparticles.
Lipid nanoparticles formulations have been developed as one method of drug delivery to cancer. Recently, a type of vaccine for COVID-19 has been developed, in which lipid nanoparticles are designed to encapsulate mRNA, the basis of the virus' protein, in the lipid nanoparticles.
The production and reproducibility of monodisperse liposomes and lipid nanoparticles with a narrow particle size distribution is critical for pharmaceuticals. There is a need to develop scalable manufacturing processes for drug delivery and controlled drug release, as parameters such as particle size affect the rate of drug uptake and efflux.
In general, batch processing makes it difficult to control the synthesis process, which can lead to particle agglomeration and a wide particle size distribution. In contrast, microfluidic technology methods have shown the potential to achieve better control than conventional batch methods. The low Reynolds number and diffusion-dominated nature of typical microfluidics make it one of the preferred methods for lipid nanoparticles production.
A water-soluble fluid merges with a fluid dissolving lipids in ethanol or methanol in a microfluidic channel. Lipid particles are self-assembled by the merging of water and ethanol in the microfluidic channel. Particle size can be controlled by changing the mixing ratio and total flow velocity of the water-soluble and lipid-soluble fluids.
*Including some distributors, etc.
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Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
CD Bioparticles, founded in Shirley, New York, is a manufacturer of biocompatible drug delivery systems. The company's product portfolio includes Liposomes, PEGylated liposomes, Polymer microspheres, Nanoparticles and Functional Biomedical Coatings. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. They also provide Contract services of drug delivery formulation developments, Product Selection Guidance, customer support, custom research projects and customized services.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.