8 Lipid Nanoparticle Manufacturers in 2024
This section provides an overview for lipid nanoparticles as well as their applications and principles. Also, please take a look at the list of 8 lipid nanoparticle manufacturers and their company rankings. Here are the top-ranked lipid nanoparticle companies as of November, 2024: 1.ABP Biosciences, LLC, 2.Creative BioStructure, 3.BOC Sciences.
Table of Contents
What Are Lipid Nanoparticles?
Lipid nanoparticles (LNP) are nanoscale particles made of lipids that are widely used in the pharmaceutical industry. Their structure allows for the encapsulation of various types of drugs: water-soluble drugs in their aqueous core, and lipophobic drugs in the hydrophobic parts. This versatility makes them ideal for drug delivery systems (DDS), where they can transport medications directly to targeted tissues.
Modifications to the size of lipid nanoparticles or the addition of surface antibodies enable precise drug delivery. LNPs are also being utilized to create nano-gas bubbles for medical purposes, encapsulating medical gases within the particles.
Uses of Lipid Nanoparticles
Lipid nanoparticles have been instrumental in developing treatments for various medical conditions, including cancer. One of the most notable recent applications is in COVID-19 vaccines, where LNPs encapsulate mRNA, the genetic blueprint for the virus's protein, facilitating effective immune response stimulation.
Advantages and Principles of Lipid Nanoparticle Fabrication Using Microfluidic Technology
The manufacturing of lipid nanoparticles requires precision to ensure a consistent and effective particle size distribution, which is crucial for drug delivery and controlled release. In pharmaceuticals, particle size significantly impacts the rate of drug absorption and release.
Traditional batch processing methods often struggle with maintaining consistent control over the synthesis process, which can result in particle agglomeration and a broad size distribution. However, microfluidic technology offers a more refined approach. Due to its low Reynolds number and diffusion-dominated characteristics, microfluidics is increasingly preferred for LNP production.
In this process, a water-soluble fluid is combined with a lipid-soluble fluid within a microfluidic channel. The interaction between these two fluids leads to the self-assembly of lipid particles. By adjusting the mixing ratio and flow velocity of the two fluids, precise control over particle size can be achieved, ensuring uniformity and effectiveness in drug delivery.
List of 8 Lipid Nanoparticle Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- Canada
- Germany
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MilliporeSigma
MISSION esiRNA
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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Creative BioStructure
Lipid Nanoparticle
Company Overview
Creative BioStructure, established in 2005 and based in Shirley, New York, USA, is a manufacturer and supplier of structural biology and membrane protein technologies products. The company's product range includes UniCrys Crystallization Products, MagHelix Electron Microscopy Products, Virus-like Particle Products, Liposome Products, and Exosome Products. These products support detailed studies in structural biology. These products serve industries such as academia, biotech, pharmaceutical, and research sectors. The company offers services like Structural Biology Services, Custom Protein Production, Protein Engineering and Analysis, and Virus-like Particle (VLP) Services.
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CD Bioparticles
Solid Lipid Nanoparticle
Company Overview
CD Bioparticles, founded in Shirley, New York, is a manufacturer of biocompatible drug delivery systems. The company's product portfolio includes Liposomes, PEGylated liposomes, Polymer microspheres, Nanoparticles and Functional Biomedical Coatings. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. They also provide Contract services of drug delivery formulation developments, Product Selection Guidance, customer support, custom research projects and customized services.
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BOC Sciences
Lipid Nanoparticles
Company Overview
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
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Lonza
LNP encapsulation
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Lipid Nanoparticle Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | ABP Biosciences, LLC |
23.8%
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| 2 | Creative BioStructure |
15.6%
|
| 3 | BOC Sciences |
13.1%
|
| 4 | Lonza |
11.5%
|
| 5 | Acuitas Therapeutics |
11.5%
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| 6 | CD Bioparticles |
11.5%
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| 7 | CordenPharma International |
7.4%
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| 8 | MilliporeSigma |
5.7%
|
Derivation Method
The ranking is calculated based on the click share within the lipid nanoparticle page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
- Acuitas Therapeutics: 2009 (15 years ago)
- Lonza: 1897 (127 years ago)
Company with a History
- Lonza: 1897 (127 years ago)
- Acuitas Therapeutics: 2009 (15 years ago)
Lipid Nanoparticle Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Lipid Nanoparticle Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
United States of America
|
1 | 33.3% |
Germany
|
1 | 33.3% |
Canada
|
1 | 33.3% |
