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This section provides an overview for preparative hplcs as well as their applications and principles. Also, please take a look at the list of 12 preparative hplc manufacturers and their company rankings. Here are the top-ranked preparative hplc companies as of December, 2024: 1.Dycem Technologies Limited, 2.Interchim, 3.Sartorius AG.
Table of Contents
Preparative HPLC (high-performance liquid chromatography) is a technique that separates and collects components from a mixture. It's widely used for purifying main components or collecting trace amounts of impurities contained in samples. Utilizing the same principles as standard HPLC analysis, Preparative HPLC achieves separation and purification based on compound characteristics like chemical structure, molecular weight, and steric structure. This process can be scaled from milligrams to kilograms by adjusting the column size and instrument configuration.
Preparative HPLC is essential in various fields:
Used to separate and obtain individual components after chemical synthesis, particularly in organic and biochemistry fields where samples often contain impurities and by-products.
Allows the collection of separate fractions for the analysis of main components and impurities, essential in material and chemical industries for evaluating sample purity and analyzing side reactions.
Employed in biological fields for purifying proteins and macromolecules, using size-exclusion chromatography columns for precise fractionation.
Utilized for extracting specific compounds from complex natural product samples, often employing reversed-phase columns for high-resolution separation.
Preparative HPLC operates similarly to analytical HPLC, separating compounds based on their interaction with the stationary phase in the column. Columns packed with porous silica gel or functional group-modified silica gel facilitate the separation of components based on their physicochemical properties as they pass through the column.
The stationary phase function varies depending on its composition. Normal phase mode uses silica gel with organic solvents, while reversed-phase mode, typically employing C18-modified silica gel, separates substances based on their hydrophilic or lipophilic nature.
Preparative HPLC can be coupled with a fraction collector to separate and collect eluates at specific times, allowing for the concentration and purification of target products.
A recycling preparative HPLC system uses a switching valve to pass eluates through the column multiple times, enhancing separation efficiency. This setup mimics the effect of a longer column, providing better resolution but requiring a dedicated device.
*Including some distributors, etc.
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PerkinElmer Inc., founded in 1937, is an American manufacturer headquartered in Waltham, Massachusetts, specializing in laboratory technology and management. The company's product offerings include analysis and characterization instruments, software, and consumables. Such offerings cover chromatography, mass spectrometry, molecular and atomic spectroscopy. They also provide immunoassay and food quality analyzers, as well as the simultaneous thermal analyzer (STA). These products find applications in various industries, such as biopharmaceuticals, food safety, lithium battery, and water resource management. PerkinElmer also offers OneSource Laboratory Services, providing knowledge, application, and service solutions for scientific laboratories. Additionally, their LABStartUp program supports new laboratories with instrumentation, consumables, and funding.
Agilent Technologies, Inc. is a global supplier headquartered in Santa Clara, California, that provides instruments, software, services, and consumables for laboratories, was established in 1999 as a spin-off from Hewlett-Packard. The company serves analytical laboratories and the clinical and routine diagnostics markets with a full suite of technology platforms. These include automation, bioreagents, gas and liquid chromatography, informatics, and vacuum technologies. They provide critical tools and capabilites that help customers address some of humanity’s biggest challenges including disease detection and therapeutics, environmental health, and food safety.
Surplus Solutions LLC, founded in 2006 and based in Woonsocket, Rhode Island, is a supplier of pre-owned laboratory and process equipment. The company specializes in sourcing, refurbishing, and reselling reusable equipment for pharmaceutical, biotech, and research industries. Its main products encompass lab instruments, packaging machinery, and production equipment. These assets find applications in drug development, quality control, and manufacturing processes. The company is AMEA and MDNA-approved, ensuring the quality of its products.
Interchim, founded in 1970, is a scientific instruments and chromatography equipment manufacturer and distributor headquartered in France. Chromatography is a laboratory technique used for separating and analyzing mixtures of compounds, making it essential in various scientific and industrial applications. The company offers a range of chromatography systems and equipment, including liquid chromatography (LC) and preparative chromatography systems. Additionally, the company provides a wide range of consumables and accessories, such as columns, cartridges, detectors, and sample preparation tools, to support chromatography processes.
Dycem Technologies Limited is a manufacturer and supplier of floor-level contamination control solutions for cleanrooms and critical environments, established in 1966 and based in Warwick, United States of America. The company presents the customers with fixed, semi-permanent solutions for controlling contamination at floor level and solutions for controlling floor-level contamination in areas with heavy-wheeled traffic. It also provides push pads, bench mats, and cleaning fluids. These products are used all over the world to protect critical environments. It has met the requirements of BS EN ISO 9001:2015 and BS EN ISO 14001:2015.
Shimadzu Corporation, founded in 1875 and based in Nakagyo Ward, Kyoto, is a Japanese manufacturer and supplier specializing in precision instruments, measuring instruments, and medical equipment. The company's products and solutions cater to various industries, including pharmaceuticals, environmental, and research institutions. For instance, Shimadzu produces analytical and measuring instruments like chromatographs and spectrometers, utilized for quality control as well as research and development in the environment, life science, and pharmaceutical fields. Furthermore, Shimadzu's medical products and systems aid in early disease detection and treatment, particularly for conditions like cancer. Additionally, Shimadzu supports manufacturing activities by providing vacuum equipment and industrial machinery.
Sartorius AG was founded in 1870 and specializes in lab products and bioprocess solutions. The company has its headquarters in Gottingen, Germany with locations in major biopharma markets including the Americas and Asia Pacific. Sartorius' range of solutions includes instruments, consumables, and services for chemical, food, biopharmaceutical, and academic laboratories. The company offers automated bioreactors and fermenters, a portfolio of cell culture media, and a range of laboratory essentials such as balances and filtration devices. The company also offers regular preventive maintenance services.
JASCO Incorporated, a company established in 1958, based in Easton, Maryland, USA, is a subsidiary of JASCO International Co., Ltd, a manufacturer and distributor of analytical and scientific instruments. The company provides product solutions for various industrial and research applications such as spectroscopy, chromatography, microscopy, and surface science. It has a range of products such as FTIR spectrometers, UV-Vis-NIR spectrometers, fluorescence spectrometers, circular dichroism spectrometers, HPLC systems, polarimeters, microscopes, and ellipsometers. These products are designed to operate with high performance, quality, and reliability.
Gilson Incorporated is a manufacturer and distributor of liquid handling, purification, and extraction equipment established in 1957 and based in Middleton, Wisconsin. The company offers pipettes, pipette tips, pipette accessories, and benchtop devices used in various research and scientific applications such as proteomics, forensic toxicology, molecular biology, natural products, and environment & food safety. Their benchtop devices product portfolio is composed of peristaltic pumps, bottle top dispensers, MagBead extractors, microplate pipette trackers, and centrifuges, incubators & mixers.
KNAUER, established in 1962, manufactures high-end scientific instruments for research, routine analysis, quality assurance, and other applications based in Berlin, Germany. The company has supported technologies including liquid chromatography, precise handling and pumping of liquids up to high pressures, as well as flow-through detection of dissolved substances. Customizable products and solutions are one of its strengths, and it produces high-tech laboratory instruments for research, routine analysis and production. The product range includes systems, engineering solutions and components. Today, it is an established company with 180 employees that successfully develops, manufactures and markets chromatography instruments worldwide.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Dycem Technologies Limited |
23.4%
|
| 2 | Interchim |
16.0%
|
| 3 | Sartorius AG |
10.6%
|
| 4 | Surplus Solutions LLC |
9.0%
|
| 5 | Gilson Incorporated |
8.5%
|
| 6 | KNAUER Wissenschaftliche Geräte GmbH |
7.4%
|
| 7 | JASCO Incorporated |
7.4%
|
| 8 | PerkinElmer Inc. |
6.4%
|
| 9 | Agilent Technologies |
4.3%
|
| 10 | Nihon BUCHI K.K. |
3.2%
|
Derivation Method
The ranking is calculated based on the click share within the preparative hplc page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 40.0% |
|
Japan
|
3 | 30.0% |
|
Germany
|
2 | 20.0% |
|
United Kingdom
|
1 | 10.0% |
16 products found
16 products
Thermo Fisher Scientific Inc.
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Soft start/stop function Protects the column from deterioration due to pressure fluctuations. The sudden pressure fluctuation at the start of the l...
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It can be purified in stable conditions in a large oven. ■ 2 types that can be selected You can choose from two types with different temperature c...
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A fraction collector that is ideal for signing that does not require a large number of strokes. ■ Manual division You can start/stop distribution ...
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It is a compact auto sampler. Needle has adopted a highly inactible titanium. You can use 10 ml V bottom vial to reduce the remaining samples.
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With the touch panel, you can check the status of the connection device and direct direct control. An error content is also displayed when an error...
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Micro to large -scale amount by replacing small UV detector cells The data is imported on a dedicated channel, so you can use it even if you use an...
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Preparative HPLC is a system for extracting and purifying target components after separation by HPLC. The preparative separation system PLC761 can ...
Repligen Japan LLC
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Repligen is revolutionizing modern chromatography methods. The result is unprecedented recovery rates and operational efficiency, even for the most...
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