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This section provides an overview for ethyl bromide as well as their applications and principles. Also, please take a look at the list of 41 ethyl bromide manufacturers and their company rankings. Here are the top-ranked ethyl bromide companies as of December, 2024: 1.Toronto Research Chemicals, 2.MilliporeSigma, 3.WeylChem International GmbH.
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Figure 1. Basic Information on Ethyl Bromide
Ethyl bromide, also known as bromoethane, is a halogenated hydrocarbon with the chemical formula C2H5Br.
It is classified under various laws due to its hazardous and toxic nature. Under the Industrial Safety and Health Law, it is labeled as hazardous and toxic, needing notification, and classified as a flammable substance. The Labor Standards Law identifies it as a disease-causing chemical substance, while the Poisonous and Deleterious Substances Control Law and the Fire Service Law categorize it as a deleterious substance and a hazardous material, respectively. Protective equipment is essential when handling ethyl bromide.
As an ethylating agent in organic synthesis, ethyl bromide is used to create ethyl esters from carboxylates and synthesize ethylamine by ethylating amines. It also serves as a raw material for the indispensable Grignard reagent in organic synthesis and is utilized in pharmaceutical manufacturing, including anesthetics.
With a melting point of -119°C and a boiling point of 38.4°C, ethyl bromide is a colorless, volatile liquid with an ethereal odor. It is highly flammable, with a flash point below -2°C, and has an explosive range of 6.8-8.0%. Insoluble in water, it dissolves slightly at 20°C and is soluble in organic solvents like ethanol and benzene. Exposure to ethyl bromide can cause severe irritation and poisoning symptoms upon inhalation, skin contact, or eye exposure.
Abbreviated as EtBr, ethyl bromide is formed by replacing one hydrogen atom in ethane with a bromine atom. It has a molecular weight of 109.0 g/mol and a density of 1.4 g/cm3.
Figure 2. Synthesis of Ethyl Bromide
Synthesis typically involves the addition of hydrogen bromide to ethylene, or distillation of ethanol with hydrobromic acid and a small amount of sulfuric acid, also producing diethyl ether as a byproduct. Alternatively, ethyl bromide can be produced from ethanol using thionyl bromide (SOBr2) or phosphorus tribromide (PBr3).
Figure 3. Reaction of Ethyl Bromide
Ethyl bromide reacts with alkali to form ethylene and is a cost-effective reagent for preparing Grignard reagents. In organic chemistry, it serves as a superior alkylating agent compared to ethyl chloride, facilitating the synthesis of ethyl esters, ethylation of pseudo-carbanions, and production of ethylisothiouronium salts and ethylamine.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Restek Corporation is a chromatography products manufacturer founded in 1985 and headquartered in Bellefonte, Pennsylvania. The company offers various products including sample preparation and collection products like solid phase extraction (SPE) cartridges, liquid chromatography (LC) and supercritical fluid chromatography (SFC) columns, and reference standards used for calibration and quality control purposes. Other products include accessories such as flow meters, regulators, and valves. These are used for monitoring the quality of soil, air, and water, as well as petrochemicals and pharmaceuticals. Restek Corporation provides clients with tech support, product education, and custom solution services.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
VulcanChem is a supplier of research chemicals and biochemical products, located in California, United States, founded in 2017. The company specializes in providing a wide range of compounds such as inhibitors, peptides, APls, impurities, natural products, and signature products to the research and pharmaceutical industries. It offers an extensive catalog of chemicals used in various scientific disciplines, including life sciences and drug discovery. It provides compounds to research institutions and pharmaceutical companies seeking chemical solutions for scientific endeavors.
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd. (HHSPT) is a Chinese ISO 9001 certified manufacturer of intermediates, active pharmaceutical ingredients (APIs), and fine chemicals founded in 2013 and based in Hefei City. The company offers over 5,000 different products including coenzyme and nucleotide series chemicals, as well as APIs for the treatment of conditions such as diabetes and chronic liver disease. It also provides reagents and chemicals used for research and analysis applications. HHSPT products are primarily used by drug manufacturers, as well as by clients in laboratory R&D and the biotechnology industry.
Jinan Qinmu Fine Chemical Co., Ltd., established in 2008, is a Chinese manufacturer of chemical products, headquartered in Jinan, Shandong. The company offers organic and inorganic chemicals, including solvent chemicals, catalysts, and auxiliaries. Additionally, the company provides dye and pigment chemicals, pharmaceutical and synthetic intermediates, active pharmaceutical ingredients (APIs), and biochemical products. Customized intermediates are also available to meet the specific needs of original equipment manufacturers (OEMs). As an ISO 9001 and ISO 14001 certified company, Qinmu Fine Chemical Co., Ltd. serves a global customer base, including clients like Miwon Specialty Chemical Co., Ltd., Synthos S. A., and Gujarat Fluorochemicals Limited (GFL).
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
CPAChem Ltd, founded in 2001 and based in Bogomilovo, Bulgaria, is a manufacturer of organic and inorganic custom-made certified reference materials as well as pharmacopoeia products and Analytical CRMs. With the capability to produce more than 200 different products daily, it stands as the sole global producer offering products in accordance with seven different pharmacopoeias, including the Japanese, Indian, and British pharmacopoeias. The company boasts a catalog of over 9,000 stock products, serving clients such as Carlo Erba, Fisher, and VWR. It holds ISO 9001 certification and has achieved accreditation in ISO/IEC 17025 and ISO 17034.
Capot Chemical Co.,Ltd was established in 1996 and is a manufacturer of custom synthesis products based in Hanghzhou, P.R. China. The company manufactures various organics products such as boronic acids, unnatural amino acids, cross linkers, chiral building blocks, and heterocyclic compounds. The management of the company have obtained the ISO 9001:2015 standards certification for the safety management system. The company have participated in various exhibitions, such as Chemspec Europe in Basel and CPhI in Barcelona, Shanghai, Milan, and Philadelphia.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
MODY CHEMI PHARMA LTD, founded in Mumbai, Maharashtra, in 1989 is a manufacturer of lithium and bromine compounds and catalysts. The company's product portfolio includes DMH, Hydantoin, Tertbutyl Ammonium Bromide, and Calcium Bromide. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. The company exports its products to countries in Europe, the USA, China and UAE. The company has a global distribution network and an R&D center.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Veeprho, established in 2011 and headquartered in Praha, Czech Republic, is a manufacturer of industrial chemicals. It is a chemical research company involved in the research, development, and supply of synthesized impurities, metabolites, intermediates, and active pharmaceutical ingredients (APIs) through custom synthesis. These products are utilized in the global pharmaceutical industry. Its global network is comprised of manufacturing and R&D facilities in India, as well as distribution offices in New Jersey US, and United Kingdom equipped to provide immediate support within all time zones.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
LANXESS AG, established in 2004 and headquartered in Cologne, Germany, is a specialty chemical manufacturer. The company emerged from a restructuring process within Bayer AG, a German pharmaceutical and biotechnology company. As part of this transformation, certain chemical and polymer business units were spun off to create LANXESS as an independent entity. Under various brand names like Bayferrox and Colortherm for synthetic inorganic pigments, Lewatit for ion exchange resins, Bayoxide for iron oxide adsorbers, and Rely+On for disinfectant solutions, LANXESS offers a diverse range of products. These serve various industries, including agriculture, automotive, biosecurity, construction, microbial control, and mining.
WeylChem International GmbH is a German-based manufacturer and supplier of fine chemicals that was established in 2005 and headquartered in Frankfurt am Main. The company offers a diverse range of specialty products and custom manufacturing solutions, serving industries such as pharmaceuticals, agrochemicals, and electronics. WeylChem International GmbH’s product portfolio includes Home Care and I&I Cleaning, which develops bleach activators and catalysts, surfactants, soil release polymers and builders. The company also provide services such as analytical services, contract development and custom synthesis.
ICL Group Ltd. is a multinational manufacturer specializing in fertilizers, metals, and specialized chemicals. Its diverse range of products serves agriculture, food, and engineered materials sectors. The company produce potash and phosphate fertilizers for enhanced crop yields, alongside tailored specialty fertilizers. Additionally, functional ingredients to elevate food texture, taste, and nutrition, flame retardants for fire prevention and magnesia products used across industries, including pharmaceutical and environmental applications are also offered. The company operates globally with sites in Israel, Europe, North/South America, and China, supported by extensive distribution and supply networks.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
MainChem Co., Ltd, established in 2014, is a Chinese manufacturer and distributor of fine and specialty chemicals, with its headquarters located in Xiamen, Fujian. The company's product portfolio includes life science chemicals, petrochemicals, and specialty chemicals. Some of MainChem’s chemical substances have passed evaluations based on Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH), a European Union regulation. These chemicals are used in various industries, including cosmetics, food additives, personal care product, and water treatment. MainChem offers the "ONE-STOP" solution for chemical sourcing from China. They also provide custom chemical synthesis services, encompassing the entire process from initial research to commercial-scale production.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Chemical Bull, founded in 2006, is an ISO9001:2015 certified manufacturer and supplier of chemicals headquartered in Vapi, Gujarat. The company's product portfolio features 300 categories of chemicals with 3000+ chemical products, including hydrochlorides, caffeine sodium benzoate, monobutyl compounds, 3-Kat inhibitors, and 3-alpha hydroxysteroid dehydrogenase inhibitors, among others. The company serves businesses, factories, and industries related to agrochemical and fertilizer, cosmetics, food, medicine, and pharmaceuticals across Europe, Asia, North America, Africa, and Oceania.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Merck Millipore, founded in 1954 and headquartered in Darmstadt, Germany, is a manufacturer, distributor, and supplier of life science products and services. Their diverse range of products finds applications in research, development, and manufacturing of biotechnological and pharmaceutical drug therapies. Some of their offerings include filters for removing contaminants from liquids and gases, chromatography columns for separating and analyzing complex mixtures, reagents used in various laboratory assays, antibodies for detecting and quantifying specific molecules, and cell culture media for growing and maintaining cells in culture. Their products and services are utilized significantly in the advancement of life sciences and drug development.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Shanghai Theorem Chemical Technology Co., Ltd., established in 1997, is a company located in Shanghai, China, is a manufacturing company specializing in researching and manufacturing chemical new materials and fine chemicals. The company offers new functional materials, surfactants, polyurethane chemicals, special isocyanates, extractants, and more. They have a product chain advantage and offer professional technical support, and stable production supply with authorized ISO9001 quality management system, ISO14001 environmental management system, as well as related certifications. Their manufacturing factory with a land area of 80,000 m2, has over 300 workers, 30 engineers, 7 production workshops.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Alsachim, headquartered in Strasbourg, France, is a supplier of reference standards and stable isotope-labeled compounds for analytical and life science research. Established in 2005, the company produces a wide range of compounds, including pharmaceutical reference standards, metabolites, drug impurities, and environmental contaminants. These products serve industries such as pharmaceuticals, biotechnology, clinical research, and environmental analysis. The company's products find application in analytical method development, pharmacokinetics, and biomarker discovery, enabling advancements in drug development, toxicology, and environmental monitoring.
Echemi Digital Technology Co. Ltd., started in 2015 and based in Hong Kong, China, is a supplier of chemical raw materials through its B2B digital commerce platform. The company sells products such as propylene carbonate, adipic acid, and oseltamivir phosphate and serves over 100,000 buyers and over 20,000 suppliers in more than 190 countries worldwide. It also provides price and market analysis of over 500 raw materials per week in the areas of coatings, fine chemicals, and pharmaceuticals. It also covers food and nutrition and was ranked 55th in the 2022 ICIS top 100 chemical distributors.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Toronto Research Chemicals |
36.4%
|
| 2 | MilliporeSigma |
13.6%
|
| 3 | WeylChem International GmbH |
9.1%
|
| 4 | MODY CHEMI PHARMA LTD |
9.1%
|
| 5 | LANXESS |
9.1%
|
| 6 | Tokyo Chemical Industry Co., Ltd. |
9.1%
|
| 7 | HAZMAT Resource, Inc. |
4.5%
|
| 8 | ICL |
4.5%
|
| 9 | Biosynth |
4.5%
|
Derivation Method
The ranking is calculated based on the click share within the ethyl bromide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
China
|
8 | 28.6% |
|
United States of America
|
5 | 17.9% |
|
India
|
5 | 17.9% |
|
Japan
|
3 | 10.7% |
|
United Kingdom
|
1 | 3.6% |
|
Bulgaria
|
1 | 3.6% |
|
Canada
|
1 | 3.6% |
|
Switzerland
|
1 | 3.6% |
|
Germany
|
1 | 3.6% |
Spain
|
1 | 3.6% |
|
France
|
1 | 3.6% |
