12 Theobromine Manufacturers in 2024
This section provides an overview for theobromine as well as their applications and principles. Also, please take a look at the list of 12 theobromine manufacturers and their company rankings. Here are the top-ranked theobromine companies as of November, 2024: 1.MedChemExpress, 2.Toronto Research Chemicals, 3.Santa Cruz Biotechnology, Inc..
Table of Contents
What Is Theobromine?
Theobromine, an alkaloid with the chemical formula C7H8N4O2 and a molecular weight of 180.17, is a colorless or white crystal. Found in cocoa seeds at 1.5-3%, it can be isolated from these seeds or chemically synthesized by methylating xanthine. Theobromine is insoluble in water, but soluble in acids and alkalis.
While it has a stimulant effect similar to caffeine, it is considered weaker. Theobromine is used in beverages, foods, pharmaceuticals, and supplements.
Uses of Theobromine
Beverages and Foods:
Theobromine, found in chocolate and cocoa, imparts a distinctive bitterness and flavor. It offers a milder stimulant effect than caffeine, making it a choice in certain beverages and foods.
Medications and Supplements:
Used to treat high blood pressure and asthma, theobromine's vasodilator and bronchodilating properties make it effective. As a dietary supplement, it is marketed for its potential cognitive and neurotrophic benefits.
Properties of Theobromine
Theobromine is a colorless crystalline solid with a bitter taste. It is virtually insoluble in water but soluble in ethanol and ether. It decomposes when heated, potentially releasing ammonia and other gases. Theobromine's interaction with adenosine receptors leads to its weak stimulant effect on the central nervous system, along with vasodilator and bronchodilator effects.
Structure of Theobromine
As a xanthine derivative, theobromine consists of a xanthine fused to a pyrimidine ring, with methyl groups at the 3- and 7-positions. Its structure includes four nitrogen atoms and two oxygen atoms, contributing to its bioactivity.
Other Information on Theobromine
How Theobromine Is Produced:
Theobromine is extracted from natural cocoa beans or synthesized using nucleosides or compounds with pyrimidine rings, such as xanthine and guanine. The extraction method involves removing fatty cacao butter, dissolving cocoa solids in alkaline solutions, and then extracting and purifying theobromine. This method is more commonly used than synthesis due to production costs.
List of 12 Theobromine Manufacturers
*Including some distributors, etc.
Sort by Features
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- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- Canada
- Germany
- India
- Japan
- United Kingdom
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MedChemExpress
Theobromine
Manufacturer Overview
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
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Cayman Chemical Company
Theobromine
Manufacturer Overview
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
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Santa Cruz Biotechnology, Inc.
Theobromine
Company Overview
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
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KANTO CHEMICAL CO.,INC.
Theobromine
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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SimSon Pharma Limited
Theobromine
Manufacturer Overview
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
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Toronto Research Chemicals
Theobromine
Manufacturer Overview
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
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Tokyo Chemical Industry Co., Ltd.
Theobromine
Manufacturer Overview
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
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MilliporeSigma
Theobromine
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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Alfa Aesar, Thermo Fisher Scientific.
A11861 Theobromine, 99%
Company Overview
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
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Carl Roth GmbH + Co. KG
Theobromine, 10 g
Company Overview
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
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APExBIO Technology LLC
Theobromine
Company Overview
APExBIO Technology LLC is a distributor and supplier of molecular biology tools based in Houston, Texas, United States. The company's product portofolio includes various products such as small molecule inhibitors, compound libraries, fluorescent labels, modified nucleotides, and assay kits. The products are used in various areas such as cancer, immunology, neurosciences, apoptosis, and epigenetics researches. The company offers various supporting services such as analytical services, custom organic synthesis, custom peptide synthesis, and bioinformatics services.
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HAZMAT Resource, Inc.
Theobromine, 99%
Distributor Overview
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
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Theobromine Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MedChemExpress |
37.5%
|
| 2 | Santa Cruz Biotechnology, Inc. |
18.8%
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| 3 | Toronto Research Chemicals |
9.4%
|
| 4 | MilliporeSigma |
9.4%
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| 5 | SimSon Pharma Limited |
6.3%
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| 6 | Cayman Chemical Company |
6.3%
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| 7 | HAZMAT Resource, Inc. |
3.1%
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| 8 | Carl Roth GmbH + Co. KG |
3.1%
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| 9 | Tokyo Chemical Industry Co., Ltd. |
3.1%
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| 10 | Alfa Aesar, Thermo Fisher Scientific. |
3.1%
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Derivation Method
The ranking is calculated based on the click share within the theobromine page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
Newly Established Company
- Toronto Research Chemicals: 1982 (42 years ago)
- Cayman Chemical Company: 1980 (44 years ago)
- Tokyo Chemical Industry Co., Ltd.: 1946 (78 years ago)
Company with a History
- Carl Roth GmbH + Co. KG: 1879 (145 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Tokyo Chemical Industry Co., Ltd.: 1946 (78 years ago)
Theobromine Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Theobromine Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
United States of America
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3 | 33.3% |
Japan
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2 | 22.2% |
India
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1 | 11.1% |
Canada
|
1 | 11.1% |
United Kingdom
|
1 | 11.1% |
Germany
|
1 | 11.1% |
