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This section provides an overview for uracil as well as their applications and principles. Also, please take a look at the list of 14 uracil manufacturers and their company rankings. Here are the top-ranked uracil companies as of December, 2024: 1.Shree Sai Life Sciences, 2.JOSHI AGROCHEM PHARMA PVT LTD, 3.Santa Cruz Biotechnology, Inc..
Table of Contents
Uracil is a pyrimidine base with the chemical formula C4H4N2O2 and is one of the four nucleobases that constitute ribonucleic acid (RNA). It is represented by the letter U in RNA sequences and is a colorless solid with a molecular weight of 112.09.
While bases such as adenine, guanine, and cytosine are found in both DNA and RNA, uracil is exclusive to RNA, replacing thymine in DNA sequences during transcription to RNA.
Uracil is a crucial component of RNA, playing a vital role in genetic information transmission and protein synthesis. It is also used in the pharmaceutical industry as a synthetic ingredient in anticancer drugs, including fluorouracil (5-FU), a fluorinated derivative effective against various cancers.
Uracil is slightly soluble in water and soluble in alcohol. It undergoes oxidation, nitration, and alkylation, and forms base pairs with adenine in RNA. In the presence of phenol and sodium hypochlorite, uracil is visible under UV light. Thymine in DNA is produced by methylation of uracil.
Uracil, like cytosine and thymine, has a pyrimidine ring and easily forms ribonucleosides like uridine. Phosphorylation of uridine leads to the production of UMP, UDP, and UTP, each playing a vital role in biological functions.
Uracil reacts with anhydrous hydrazine to open its ring, forming an anion at a pH above 10.5.
Fluorouracil is a fluoropyrimidine antimetabolite, acting as an inhibitor of thymidylate synthase and disrupting DNA synthesis. Its metabolite, FdUMP, inhibits DNA synthesis, while FUTP, another metabolite, interferes with RNA processing and mRNA translation.
*Including some distributors, etc.
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Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Alpha Chemika, founded in 1989 and based in Mumbai, India, is a manufacturer, supplier of laboratory reagents and fine chemicals. Their products are used in multiple industries, including pharmaceutical, chemical, biotechnology, and environmental. Their product portfolio ranges from chemicals such as Silver Nitrate, Perchloric Acid, and Lanthanum Acetate to laboratory tools and equipment such as Air Inlet Tubes, Air Inlet Tubes, and Optical Components. Alpha Chemika has been able to obtain ISO 9001:2000 certification.
Capot Chemical Co.,Ltd was established in 1996 and is a manufacturer of custom synthesis products based in Hanghzhou, P.R. China. The company manufactures various organics products such as boronic acids, unnatural amino acids, cross linkers, chiral building blocks, and heterocyclic compounds. The management of the company have obtained the ISO 9001:2015 standards certification for the safety management system. The company have participated in various exhibitions, such as Chemspec Europe in Basel and CPhI in Barcelona, Shanghai, Milan, and Philadelphia.
Evans Chem India Pvt. Ltd., established in 1988 and situated in Maharashtra, India, functions as a manufacturer, exporter, and supplier of specialty chemicals and intermediates. Its product portfolio includes pharmaceutical intermediates, agrochemical intermediates, dyes and pigments, specialty chemicals, and fine chemicals. Among the chemicals provided are ethyl pyruvate, methyl pyruvate, pyruvic acid, and methylene blue. The products are pivotal in research, development, and biotechnology applications. The company upholds stringent quality standards, ensuring that all chemicals are processed under strict supervision.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
SUVCHEM, established in 2004 and headquartered in Mumbai, India, is a manufacturer and exporter of laboratory chemicals and reagents. Their diverse product range includes organic and inorganic chemicals utilized in pharmaceuticals, plastics, water treatment, and more. They also offer biological stains and indicators for laboratory applications like cell culture and DNA analysis, along with culture media ingredients for growing microorganisms. SUVCHEM's products cater to schools, colleges, research laboratories, pharmaceutical and chemical companies, and other industries, supporting teaching, research, product development, and manufacturing processes across various sectors.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Joshi Agrochem Pharma, established in 1971 and based in Mumbai, India, is a manufacturer, supplier, and exporter of various chemicals, solvents, and metals. The company maintains a stock of agro fertilizers, pesticides, and pharmaceuticals. It has a readily available inventory of 2,000 products, including agrochemicals, solvents, and APIs. These products are utilized in a range of industries, such as automobile, aerospace, and agriculture. The company holds ISO 9001 and ISO 14001 certification and operates as part of the Joshi Group of companies, which is comprised of four companies that are segmented to ensure smooth business in varying domains.
Indian Platinum Pvt. Ltd., established in 2011, with headquarters in India, is a manufacturer and global distributor of precious metal chemicals used in many industrial, agricultural, and commercial manufacturing processes. The company's range of products includes silver chemicals, laboratory chemicals, industrial chemicals, and palladium chemicals, which are used in organic fertilizers, nanopowders, metal-made products, industrial chemicals, and more. Indian Platinum Pvt. Ltd.'s main export countries include the USA, Bangladesh, Australia, Canada, and Nepal.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Shree Sai Life Sciences |
25.0%
|
| 2 | JOSHI AGROCHEM PHARMA PVT LTD |
12.0%
|
| 3 | Santa Cruz Biotechnology, Inc. |
9.8%
|
| 4 | SUVCHEM |
7.6%
|
| 5 | KANTO CHEMICAL CO.,INC. |
7.6%
|
| 6 | Central Drug House |
6.5%
|
| 7 | Kishida Chemical Co.,Ltd. |
6.5%
|
| 8 | Alpha Chemika |
5.4%
|
| 9 | MilliporeSigma |
4.3%
|
| 10 | Yash Chemicals |
3.3%
|
Derivation Method
The ranking is calculated based on the click share within the uracil page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
6 | 60.0% |
|
Japan
|
2 | 20.0% |
|
United States of America
|
1 | 10.0% |
|
China
|
1 | 10.0% |
