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This section provides an overview for cytosine as well as their applications and principles. Also, please take a look at the list of 10 cytosine manufacturers and their company rankings. Here are the top-ranked cytosine companies as of December, 2024: 1.SIELC Technologies, 2.Tokyo Chemical Industry Co., Ltd., 3.MedChemExpress.
Table of Contents
Cytosine is an organic compound that appears as a white or nearly white crystalline powder. It is a derivative of pyrimidine and plays a crucial role in the structure of nucleic acids. The chemical formula of cytosine is C4H5N3O, with a molecular weight of 111.10, and its CAS number is 71-30-7.
Cytosine is one of the five major nucleobases found in DNA (deoxyribonucleic acid) and RNA (ribonucleic acid), both of which contain genetic information. In the structure of DNA, cytosine is a pyrimidine base with an amino group at the 4' carbon position. In the DNA double helix, cytosine forms three hydrogen bonds with guanine. Nucleobases like cytosine are attached to sugars (deoxyribose in DNA and ribose in RNA) and phosphate groups to form nucleotides, which are the building blocks of nucleic acids. The sequence of these nucleotides in nucleic acids carries genetic information.
Cytosine is more soluble in hot water than in cold water and is insoluble in ethanol and acetone. It is chemically stable, with its primary vulnerability being potential alteration by light exposure.
Cytosine is primarily used in organic synthesis as a raw material. As a component of nucleic acids, it is present in the cells of all living organisms, making it significant for various biological functions. In the medical field, cytosine has potential applications, although its practical uses are currently limited to research and development stages, including animal experiments and patent applications.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
SIELC Technologies is a specialized manufacturer and developer of high-performance liquid chromatography (HPLC) columns, devices, and systems. The company was founded in 2001 and is based in Illinois, with a network of partner distributors in over 30 countries across six continents. The company's product portfolio is centered around various HPLC columns including chiral, normal- and reverse-phase, ion-exchange, and mixed-mode models. These supply clients in the biotech, pharmaceutical, petrochemical, and cannabis industries.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | SIELC Technologies |
33.3%
|
| 2 | Tokyo Chemical Industry Co., Ltd. |
33.3%
|
| 3 | MedChemExpress |
22.2%
|
| 4 | MilliporeSigma |
11.1%
|
Derivation Method
The ranking is calculated based on the click share within the cytosine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 50.0% |
|
Japan
|
3 | 37.5% |
|
United Kingdom
|
1 | 12.5% |
