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This section provides an overview for bioreactors as well as their applications and principles. Also, please take a look at the list of 13 bioreactor manufacturers and their company rankings. Here are the top-ranked bioreactor companies as of January, 2025: 1.Corning Incorporated, 2.Beckman Coulter, Inc., 3.bbi-biotech GmbH.
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Categories Related to Bioreactors
Bioreactors are devices that utilize biological processes mediated by enzymes, cells, and microorganisms to produce and analyze substances. Unlike chemical reactions, biological reactions in bioreactors tend to be slower but are advantageous for producing fewer byproducts and maintaining catalytic activity without the need for high temperatures and pressures. This makes bioreactors cost-effective and essential for various applications, including cell culture.
Bioreactors find applications in numerous industries, such as:
Bioreactors operate by managing conditions such as temperature, pH, and pressure to facilitate reactions with immobilized enzymes and other biological elements, leading to the synthesis, decomposition, or conversion of materials to obtain desired products. Cells, microorganisms, and purified enzymes serve as primary reaction elements, with immobilization techniques enhancing separation efficiency from the products.
Variants of bioreactors include:
The aeration, mixing, and temperature control in bioreactors vary greatly depending on the state of the reaction materials and the type of organisms involved. Methods include aeration and agitation for aerobic organisms and specific nutrient and light supply for photosynthetic organisms. Microbioreactors, used for analysis, require precise control of temperature and volume to ensure accuracy.
Bioreactors excel in synthesizing optically active compounds, offering advantages like room temperature operation, normal pressure, neutral pH, selectivity, fewer byproducts, and higher yields.
Bioreactors are pivotal in regenerative medicine for cultivating large quantities of cells, such as iPS cells, using techniques like 3D floating cultures and specially designed agitation mechanisms to enhance culture efficiency with minimal stress on the cells.
*Including some distributors, etc.
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Corning Incorporated, founded in 1851 and headquartered in Corning, New York, is a manufacturer and supplier of specialty glass, ceramics, and optical fiber. Their offerings include optical fiber for long-distance light signal transmission, specialty glass for applications like displays and lighting, ceramics for various uses, such as cookware and medical implants, and advanced materials like 3D printing powders and ceramic matrix composites. Additionally, Corning provides products for the life sciences industry, such as labware, consumables, and analytical instruments.
Beckman Coulter, Inc. is a manufacturer of scientific research instruments primarily for the academia and pharmaceutical markets. The company is a merger between Beckman Instruments, Inc. and Coulter Corporation based in Indiana, United States with a history dating back to 1935. Beckman Coulter develops and manufactures instruments for the clinical research market, and applied markets including food and beverages, agriculture, oil and gas, and aerospace. The company's range of instrument and reagents include Air and Liquid Particle Counters, Centrifuges, and Genomic Solutions.
American Alloy Fabricators, founded in 1989, is a manufacturer of ASME-certified custom equipment such as pressure vessels, reactors, pressure filters, storage tanks, and pipping equipment such as elbows and tee fittings with gaskets used in the biotechnology, pharmaceutical, food processing, cosmetics, and nutraceuticals industries. The Norristown, Pennsylvania-based company provides custom alloy fabrication metal services, welding, and alloy fabrication finishes such as polishing using materials like stainless steel, Hastelloy, Inconel, Monel, and alloy 20.
Augusta Fiberglass, since 1974, is a manufacturer of custom-designed fabricated fiberglass and reinforced plastic products such as tanks, pipes & ducts, hoods, stacks & stack liners, and scrubbers used in chemical, food & beverage, mining, industrial and pharmaceutical industries. Located in Blackville,SC, the company offers field services such as emergency repair & maintenance, erection of vessels, inspection & modifications, fabrications and site surveys by equipped and RTP-1-certified workers. The company has an ASME RTP certificate and hence can stamp vessels with the RTP mark.
Lee Industries, Inc. is a custom processing solutions manufacturer based in Philipsburg, Pennsylvania. Founded in 1927, the company's product lineup includes vacuum evaporators for concentration and crystallization, ribbon and paddle blenders for integrating dry powders or granular mixtures, and agitators for dispersion and homogenization of product formulations. The company also offers engineering and fabrication as well as lab and pilot plant testing of custom units. Lee Industries, Inc. serves various industries, with client corporations like Procter & Gamble, Zoetis, and the Campbell Soup Company.
Glen Mill Inc. was founded in 1980 and headquartered in Clifton, New Jersey. The company is a provider of grinding and comminution equipment that reduces particle size for laboratory professionals, researchers, and engineers based around the world. The company blends and samples grinding media of all types. The company’s product list includes 3D inversion powder mixers, dry and wet milling equipment, cell disruption equipment, and sieving equipment. The company also offers rental options and grinding and tolling services for customers.
Paul Mueller Company, established in 1940, is an American manufacturer of stainless steel processing systems and equipment, headquartered in Springfield, Missouri. The company's product range includes various types of tanks for storage, processing, and serving. Additionally, Paul Mueller Company offers diverse processing systems for applications such as beverage infusion, heat recovery, and refrigeration. Furthermore, the company's PyroPure line features pure steam generators and condensing units designed for producing water-for-injection (WFI) quality pure steam and WFI quality distillate. Paul Mueller Company serves various industries including food, beverage, brewing, and wine, chemical, dairy farming and processing, oil and gas, as well as pharmaceuticals.
Hydro Engineering, Inc., founded in 1980, is a manufacturer of Hydroblaster, Hydrokleen, and Hydropad products for washing, collecting, and recycling wash water. The products are used in recycling and filtration equipment, pressure washers, and above-ground steel portable/permanent wash racks. Based in Salt Lake City, UT, the company serves car washes, construction, military, and manufacturing industries. The CE, UL, and CSA standards are applied to the products produced as the company is ISO 9001:2015 Certified. The company offers diagnostics, safety system testing, pump rebuilding, and heating system repair services for pressure washers.
GPC Bio is a bioreactor, fermenter, and processing equipment manufacturer, established in 2008 and based in Perigny, France, and Newark, USA. It manufactures benchtop bioreactors, single-use bioreactors, and photo bioreactors. It also provides bioreactor fermenters and turnkey solutions, which are greater in scale than the aforementioned products. The products are targeted at vaccine manufacturers, the food industry, veterinary, biopharmaceutical companies, and many more. It applies a quality standard of GAMP V5 (Good Automated Manufacturing Practice).
bbi-biotech GmbH is a bioreactor as well as fermenter manufacturer and distributor, established in 2009 and headquartered in Berlin, Germany. The company's range of products includes compact bioreactor/fermentor with extensive equipment capabilities, bioreactors and fermentors featuring two cultivation vessels, and multi-bioreactors capable of accommodating up to 12 parallel vessels. It also offers in-situ sterilizable photobioreactors, in-situ sterilizable airlift photobioreactors, and photobioreactors designed for microalgae cultivation in laboratory settings, catering to the biotechnology, pharmaceutical, cosmetic, and food industries. The company also collaborates with Abitep GmbH, B&R, Cercell, Gemtec, IGV Biotech, and InVivo Biotech Services GmbH in the research and development process.
Solida Biotech is a bioreactor as well as fermenter manufacturer and distributor, established in 2001 and headquartered in Munchen, Germany. It manufactures laboratory bioreactors like compact bioreactors, advanced modular bioreactors, and single-use bioreactors as well as pilot and industrial bioreactors such as SIP/CIP Pilot 20-500L Bioreactors and Fermenters and SIP/CIP Industrial 500I-30m3 Bioreactors. It also produces multi-assay analyzers, gas analyzers, online biomass sensors, automation and controllers, and Bioflex software & SCADA. The fields of applications are antibiotics, biomass, vaccines, proteins, and many others. All of Solida Biotech’s bioprocess equipment meets the latest GLP, cGMP, GAMP, FDA, and SFDA standards.
Kindle Tech is a professional laboratory equipment supplier that was founded in 2015 and is headquartered in Zhengzhou, China. Its main activity is the supply of laboratory equipment, including analytical instruments, equipment for microbiology, and equipment for environmental analysis. The company also offers a wide range of services, such as installation, calibration, and maintenance. Kindle Tech's products are used by a wide range of customers, including academic institutions, pharmaceutical companies, and environmental testing laboratories. The organization, through its specialized teamwork and rich experienced engineers, provide custom made service and equipment, custom tailoring hardware and software equipment requirements to worldwide customers.
Ranking as of January 2025
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Corning Incorporated |
17.5%
|
| 2 | Beckman Coulter, Inc. |
12.9%
|
| 3 | bbi-biotech GmbH |
10.3%
|
| 4 | American Alloy Fabricators Inc. |
8.1%
|
| 5 | Paul Mueller Company |
7.8%
|
| 6 | GPC Bio |
7.3%
|
| 7 | Solida Biotech |
6.9%
|
| 8 | Lee Industries, Inc. |
6.6%
|
| 9 | Augusta Fiberglass |
6.0%
|
| 10 | Hydro Engineering, Inc. |
6.0%
|
Derivation Method
The ranking is calculated based on the click share within the bioreactor page as of January 2025. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
8 | 66.7% |
|
Germany
|
2 | 16.7% |
Japan
|
1 | 8.3% |
|
China
|
1 | 8.3% |
73 products found
73 products
Sanyasu Sangyo Co., Ltd.
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5.0 Company Review
Light weight, space saving, energy saving, long service life and easy management. Reduced water treatment running costs (water, fuel, electricity)....
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Repligen Japan LLC
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N-1 perfusion, a form of seed train enrichment, is meant to enhance cell proliferation in the seed train step (N-1) prior to the production bioreac...
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■Achieve high productivity High Productivity Harvest (HPH) is a new application developed by Repligen. Fed-batch bioreactors can be harvested in co...
Cellfree Science Co., Ltd.
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High quality wheat germ extract rich in translation factors. Domestic laws and regulations ■Not applicable ・Act on Securing Biological Diversity ...
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BioXplorer 100 increases productivity and allows screening of cell culture conditions. The modular design and rich options allow it to be adapted t...
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■ Increased gas pressure increases gas solubility, which can generate commercial benefits in both bacterial and cell culture applications. The BioX...
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A nucleoside triphosphate solution that is a substrate for RNA polymerase. Used when creating mRNA. Domestic laws and regulations ■Not applicable ...
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■WEPRO7240 Series Expression Kit -A set of reagents necessary for protein synthesis. ・The reaction scale can be freely changed according to the cu...
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■Experiment equipment set ・The transcription/translation experiment kit & consumables set includes the necessary experiment equipment. ・Once purc...
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■Summary The Photobioreactor Control Software is a versatile solution developed for a wide range of PSI culture equipment consisting of multi-incub...
