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This section provides an overview for glutaric acids as well as their applications and principles. Also, please take a look at the list of 21 glutaric acid manufacturers and their company rankings. Here are the top-ranked glutaric acid companies as of December, 2024: 1.SHENZHEN BBIEN TECHNOLOGY CO.,LTD, 2.Hefei Home Sunshine Pharmaceutical Technology Co., Ltd., 3.Molekula Americas LLC.
Table of Contents
Glutaric acid is a type of carboxylic acid whose molecular formula is C5H8O4.
It is also called "pentanedioic acid" or "1,3-propanedicarboxylic acid. Its molecular weight is 132.11 g/mol, its melting point is 95-98 °C, and its CAS number is 110-94-1. Since it is a dicarboxylic acid, it shows relatively strong acidity when dissolved in water.
Glutaric acid is used in the preparation of solder flux and the manufacture of solder paste because of its high solubility and low residue. It is also useful as a raw material for organic synthesis of polyester polyols and polyamides. Glutaric acid reduces the elasticity of polymers.
In addition, it is used as a pharmaceutical intermediate, initiator of glutaric anhydride, l-ketoglutaric acid, and peroxyglutaric acid, as well as a flavoring agent and pH adjuster.
Glutaric acid is a white or light yellow crystalline powder. It is well soluble in water and soluble in alcohol, ether, and chloroform.
Glutaric acid is synthesized by the action of sodium cyanide on 1,3-dibromopropane to produce glutaronitrile, which is then hydrolyzed. This reaction utilizes two reactions: first, the SN2 reaction, which is formed by the nucleophilic attack of a cyanide ion on carbon, and then hydrolysis of the cyanide to form a carboxylic acid.
Glutaric acid is produced in mammals as an intermediate by catabolism of lysine, hydroxylysine, and tryptophan in an intermediate metabolic process. Deficiency of glutaryl CoA dehydrogenase, which produces glutaric acid in this process, results in a disease called Glutaric Acidemia Type I.
This disease causes severe symptoms such as dystonia, dyskinesia, degeneration of the caudate nucleus and putamen, frontotemporal atrophy, and arachnoid cysts due to the inability to metabolize amino acids normally. The disease is considered incurable, and since the biochemical profile of the disease is elevated urinary glutaric acid and 2-hydroxyglutaric acid concentrations, urinary and plasma glutaric acid is an indicator of glutaric aciduria type 1.
There is also a disorder called Glutaric Aciduria Type 2. This disease is caused by an inherited deficiency of electron transfer flavin protein (ETF) and ETF dehydrogenase (ETFDH) in the mitochondria, which supply electrons to the electron transfer system resulting from multiple dehydrogenase reactions within the mitochondria, including the beta-oxidation pathway. When these enzymes are deficient, metabolism fails. As a result, many cases of ETFDH in newborns present with severe cardiomyopathy, heart failure, and nonketotic hypoglycemia beginning shortly after birth.
Glutaric acid is obtained by replacing one hydrogen atom on the second carbon of glutaric acid with an amino group. The carbonyl group attached to the carbon at position 2 of glutaric acid is called α-ketoglutaric acid.
α-Ketoglutaric acid is a substance that plays an important role as an intermediate in the citric acid circuit, one of the metabolic pathways in mammals. The metabolic pathway of amino acids such as glutamic acid also passes through α-ketoglutaric acid as an intermediate.
Glutaric aldehyde, which is produced by treating glutaric acid with a reducing agent, is a substance often used industrially. Imports in Japan in 2007 amounted to less than 100-1,000 tons/year.
Major uses include tanning agents for hides, fixing agents for paper and rastik, disinfectants for endoscopes and surgical instruments, algaecides for cooling towers, disinfectants for poultry houses and equipment, and developers for radiographs.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd, established in 2013 and headquartered in Hefei City, China, is a manufacturer specializing in both standard and custom chemical synthesis. With manufacturing facilities in Anhui, Jiangsu, Zhejiang, and Inner Mongolia, Home Sunshine Pharma offers a range of products, including active pharmaceutical ingredients (APIs), intermediates, fine chemicals, coenzymes, and nucleotides. As an ISO 9001:2015 certified company, Home Sunshine Pharma serves research institutions, universities, and industries in Europe, America, and Southeast Asia with their chemical products.
SHENZHEN BBIEN TECHNOLOGY CO. LTD, founded in 2000, is a manufacturer of assembly materials for the electronic and microelectronic industries based in Guangdong, China. The company offers high-tech soldering materials, traditional soldering chemicals, bar and wire solder, and paste products. Its product list covers pure tin solder bars, tube packing solder wire, cartridge lead-free solder paste, ultra micro solder powder, red glue adhesives, and other chemical mixtures for the soldering sector. The company is ISO-9001 certified. It has global facilities in China, Russia, North and South America, Europe, and Asia, serving customers in 80 countries worldwide.
Witton Chemical Co. Ltd., founded in the UK in 1974, is a manufacturer of polymers and fine chemicals. The company's product portfolio includes polyacrylate dispersants, glutaric acid, and a wide range of specialized custom manufactured materials. It also provides services such as process and product development, manufacturing of existing materials, and technical and customer support. The company serves industries such as biotech companies, pharmaceuticals, food and beverage, and chemical manufacturing.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Esprix Technologies is an ISO 9001-certified manufacturer of specialty chemicals founded in 1992 in Sarasota, Florida, USA. The company produces specially formulated chemicals used in a wide range of industries. These include pharmaceutical intermediates for drug synthesis, microparticles used in cosmetics, and acrylate oligomers for adhesives. The company serves various clients in research and development, metal fabrication, and textiles. Some of its notable customers include major corporations such as L’Oreal, Pfizer, and Boeing.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
SynThink Research Chemicals, based in Pune, India, is a supplier of pharmaceutical research products to pharmaceutical and biotech companies as well as R&D labs at various research institutes and organizations. The company provides pharmaceutical reference standards, API impurities, metabolites, intermediates, building blocks and other research chemicals. It also provides custom synthesis services and contract research and development (CRO) services in the area of organic, pharmaceutical, and medicinal chemistry. The company offers custom packaging and worldwide shipping of in-stock products within 24 hours.
Fisher Scientific UK Ltd is a supplier of laboratory chemicals, equipment, and services based in Loughborough, United Kingdom, operating as a subsidiary of Thermo Fisher Scientific, a merger of Fisher Scientific International, Inc. and Thermo Electron in 2006. With a portfolio of over 2 million products, Fisher Scientific offers chemicals, reagents, equipment and instruments, consumables, and safety products. These products cater to various sectors, including clinical diagnostic and research laboratories, pharmaceutical and biotech industries, healthcare, and government agencies. Fisher Scientific also provides business solutions like the New-Lab Start-Up program, as well as SureTRACE and SureTRACE+ for product knowledge and supply chain management.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | SHENZHEN BBIEN TECHNOLOGY CO.,LTD |
13.3%
|
| 2 | Hefei Home Sunshine Pharmaceutical Technology Co., Ltd. |
13.3%
|
| 3 | Molekula Americas LLC |
13.3%
|
| 4 | Esprix |
6.7%
|
| 5 | Witton Chemical Co. Ltd. |
6.7%
|
| 6 | LobaChemie Pct.Ltd. |
6.7%
|
| 7 | Shanghai Sunwise Chemical Co., Ltd |
6.7%
|
| 8 | Central Drug House |
6.7%
|
| 9 | Tokyo Chemical Industry Co., Ltd. |
6.7%
|
| 10 | MedChemExpress |
6.7%
|
Derivation Method
The ranking is calculated based on the click share within the glutaric acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
4 | 23.5% |
|
United States of America
|
3 | 17.6% |
|
China
|
3 | 17.6% |
|
Japan
|
3 | 17.6% |
|
United Kingdom
|
2 | 11.8% |
|
Switzerland
|
1 | 5.9% |
|
Canada
|
1 | 5.9% |
