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This section provides an overview for glutamic acid as well as their applications and principles. Also, please take a look at the list of 11 glutamic acid manufacturers and their company rankings. Here are the top-ranked glutamic acid companies as of December, 2024: 1.SUVIDHINATH LABORATORIES, 2.Zhengzhou Megaman Chemical Co., Ltd., 3.Aquapharm Chemical Pvt. Ltd..
Table of Contents
Glutamic Acid is a non-essential amino acid that can be synthesized by the body. It serves as a neurotransmitter between synapses.
In the brain, glutamic acid binds to its receptors and activates them to transmit information for learning. It is also useful as a flavor component.
There are several methods of producing glutamic acid, including hydrolysis, extraction, and chemical synthesis. Currently, the amino acid fermentation method, in which glutamic acid is obtained by fermenting sugarcane molasses with fermentation bacteria, is the most common method.
The main uses of glutamic acid are in seasonings and supplements.
Glutamic Acid is one of the components of umami, so monosodium glutamate, a glutamate salt, is commercialized and sold as an umami seasoning.
In the case of chemical seasonings, glutamic acid is sold in the form of glutamic acid trim combined with sodium, which is easily dissolved in water.
Glutamic acid is abundantly contained in seaweeds such as kelp and plant foods such as Chinese cabbage, green tea, and tomatoes.
In addition to its function as one of the brain's neurotransmitters, glutamic acid plays an important function in the body, detoxifying ammonia and becoming a component of proteins that strengthen muscles and immunity.
Therefore, glutamic acid deficiency can lead to impaired brain function and inhibited urination. Glutamic acid has been commercialized as a dietary supplement with the goal of compensating for glutamic acid deficiency.
Glutamic acid also produces GABA, which calms brain excitation; GABA is a type of amino acid that has been used in supplements and foods in recent years for its stress-reducing and relaxing effects.
Glutamic Acid is a non-essential amino acid that is necessary for the production of alanine, aspartic acid, and serine, and is found in nature as L-glutamic acid.
Glutamic Acid is a white, odorless, crystalline powder with molecular formula C5H9NO4 and molecular weight 147.13. It has a boiling point of 249°C and no melting point, flash point, or decomposition temperature. It is not flammable and can be handled relatively safely.
The product is insoluble in water, and is largely insoluble in ethanol and diethyl ether. It is hazardous in contact with strong oxidizing agents.
During thermal decomposition, there is a high possibility of releasing irritating and toxic gases and vapors. Work should be done in areas with local exhaust ventilation and use is to be avoided at high temperatures.
Glutamic Acid was discovered in 1866 by the German chemist Ritthausen as a hydrolysis product of gluten, a protein of wheat. Later, in 1908, Kikunae Ikeda, a professor at Tokyo Imperial University (now the University of Tokyo), discovered that glutamic acid has a delicious taste. He also announced that in addition to the four basic tastes of sweet, salty, sour, and bitter, glutamic acid has a fifth basic taste, umami.
It was also clarified that the fifth basic taste, umami, is more easily soluble in water when it is combined with sodium. Sabrosuke Suzuki, the founder of Ajinomoto, worked to commercialize monosodium glutamic acid, and the world's first chemical seasoning was launched in 1909.
Excessive intake of natural glutamic acid can cause sleeping disorders neurosis, hallucinations, and other risks. In addition, excessive intake of the chemical seasoning monosodium glutamic acid is said to cause headaches, burning, and numbness in the hands and feet.
On the other hand, research has reported that proper intake of glutamate is beneficial to the human body in terms of activating brain function, detoxifying ammonia, and having a diuretic effect, as well as reducing the accumulation of fat, beautifying the skin, and lowering blood pressure.
As with water and salt, excessive intake of these substances can be poisonous even if they are necessary for the human body.
*Including some distributors, etc.
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Suvidhinath Laboratories was founded in 1985 and is headquartered in Gujarat, India. The company is an ISO 9001-2008 certified exporter, manufacturer, trader, and supplier of laboratory chemicals and reagents to global customers, especially across South East Asia and the Gulf countries. The company’s client list includes Cadila Pharmaceuticals Limited, Gujarat State Fertilizers & Chemicals LTD, Deepak Nitrite Limited, and Indian OIl. The company’s product categories include food-grade chemicals, pharmaceutical chemicals, laboratory chemicals, and industrial chemicals.
Zhengzhou Megaman Chemical Co., Ltd., which is based in Zhengzhou, China, is a manufacturer and supplier of bio-based products like alanine series. The company makes beta-alanine, L-alanine, L-valine, L-arginine, as well as L-glutamic acid. It also manufactures DL-aspartic acid, glycine amino acid, calcium D-pantothenate, L-isoleucine, and L-methionine. Its beta-alanine is used to synthesize pantothenic acid and calcium pantothenate, carnosine and barley nitrogen, as food and health food additives, in the production of electroplating corrosion inhibitors and biological reagents.
Yichang Sanxia Proudin Biopharmaceutical Co., Ltd., founded in China in 1974, is a manufacturer of Amino Acid series raw materials. The company's product portfolio includes Pharmaceutical Grade Amino Acids, Amino Acids for Special Medical Food, Amino Acids for Medium, High-Purity Pharmaceutical Intermediate Amino Acid and Food Grade Amino Acids. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare.
Aquapharm Chemicals Pvt. Ltd, established in 1974, is an Indian manufacturer based in Pune, Maharashtra, specializing in specialty chemicals. The company’s product range, grouped into four categories, includes acetyl chloride, biodegradable chelating agents, mercaptobenzothiazole (MBT), and phosphonates. These offerings find applications in various industries such as oil and gas, detergent, industrial cleaner, textiles, and water treatment. In 2017, the company inaugurated an innovation center furnished with laboratories engaging in the research and development of chelating and dispersing agents, corrosion inhibitors, and oil field chemicals. The research efforts and the facility itself have garnered recognition from the country’s Department of Science and Technology.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Reagents, established in 1997 and headquartered in New York, USA, is a manufacturer and distributor of laboratory chemicals and reagents. Serving academic institutions, research laboratories, pharmaceutical companies, and other industries, the company offers a diverse range of products that encompass organic and inorganic chemicals used in pharmaceuticals, plastics, water treatment, and more. They provide biological stains and indicators for laboratory applications like cell culture and DNA analysis, along with culture media ingredients for microbial growth. Their product portfolio also caters to applications in batteries, pigments, and catalysts. Reagents' comprehensive offerings support education, research, and manufacturing processes across various sectors.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Anant Pharmaceuticals Pvt. Ltd., established in 2005, is a supplier of pharmaceutical impurity reference samples and custom synthesis and analytical services, based in India. The company delivers novel solutions to research and development teams. Their organic synthesis labs are equipped with modern equipment, designed with energy saving concept. Over the years, they have developed into a one-stop service provider for bespoke chemical synthesis and analytical services for a wide range of industries in India and abroad.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | SUVIDHINATH LABORATORIES |
17.1%
|
| 2 | Zhengzhou Megaman Chemical Co., Ltd. |
17.1%
|
| 3 | Aquapharm Chemical Pvt. Ltd. |
17.1%
|
| 4 | Yichang Sanxia Proudin Biopharmaceutical Co., Ltd. |
11.4%
|
| 5 | Merck |
11.4%
|
| 6 | Anant Pharmaceuticals Pvt. Ltd. |
5.7%
|
| 7 | Reagents |
5.7%
|
| 8 | nacalai |
5.7%
|
| 9 | Central Drug House |
2.9%
|
| 10 | Glentham Life Sciences Limited |
2.9%
|
Derivation Method
The ranking is calculated based on the click share within the glutamic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 55.6% |
|
China
|
2 | 22.2% |
|
Japan
|
1 | 11.1% |
|
United Kingdom
|
1 | 11.1% |
