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This section provides an overview for coumaric acids as well as their applications and principles. Also, please take a look at the list of 24 coumaric acid manufacturers and their company rankings. Here are the top-ranked coumaric acid companies as of December, 2024: 1.Nanjing NutriHerb BioTech Co.,Ltd, 2.MP Biomedicals, 3.Markherb.
Table of Contents
Figure 1. Basic Information on p-Coumaric Acid
Coumaric acid is a hydroxy derivative of cinnamic acid, not silicylic acid as previously mentioned. It includes three isomers: p-coumaric acid, m-coumaric acid, and o-coumaric acid, depending on the hydroxy group's position on the phenyl group. p-Coumaric acid, the most abundant naturally occurring form among these, is found in various edible plants such as tomatoes, peanuts, garlic, and carrots. It is also referred to as 4-hydroxycinnamic acid or β-(4-hydroxyphenyl)acrylic acid.
Coumaric acid is primarily used as a reagent in chemical research. It serves as a component in chemiluminescent substrates for protein detection in western blotting. Additionally, coumaric acid inhibits the formation of nitrosamines, carcinogens formed by the reaction of amines with nitrites in food additives. This inhibition is particularly relevant to reducing the risk of stomach cancer, making p-coumaric acid a subject of ongoing research.
p-Coumaric acid is a crystalline solid with a melting point of 410-415.4°F (210-213°C) and a boiling point of 449°F (231.61°C). It is insoluble in water but dissolves well in diethyl ether and ethanol.
Figure 2. Structure of Coumaric Acid
The molar mass of coumaric acid is 164.16 g/mol, with a chemical formula of C9H8O3. It features a structure of a hydroxy group bonded to a phenyl group. Among its forms, trans-p-coumaric acid is a major component of lignin. p-Coumaric acid derivatives, such as p-coumaric acid glucoside, are found in various natural products, including bread containing ama seeds and carnauba wax.
Figure 3. p-Coumaric Acid Synthesis
p-Coumaric acid is produced by the cytochrome P450-dependent enzyme trans-cinnamic acid-4-monooxygenase from cinnamic acid and from L-tyrosine by tyrosine ammonia lyase.
p-Coumaric acid is a precursor to 4-ethylphenol in wine, produced by Brettanomyces yeast. It is converted from coumaric acid to 4-vinylphenol by 4-hydroxycinnamic acid decarboxylase and then reduced to 4-ethylphenol by vinylphenol reductase. Additionally, cis-p-coumaric acid glucosyltransferase synthesizes p-coumaric acid glucoside from cis-p-coumaric acid and UDP-glucose.
m-Coumaric acid and o-coumaric acid, found in vinegar, are produced through various metabolic pathways involving enzymes like 2-coumaric reductase, which is involved in phenylalanine metabolism.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
California Pacific (CP) Lab Safety is an American manufacturer and distributor of laboratory safety solutions founded in Novato, California in 1996. The company produces both lab and environmental safety equipment and devices, including waste containers, safety vents, biodegradable bags, and personal protective equipment (PPE). They also offer custom design and engineering services for customer projects, as well as technical support and quality assurance. CP Lab Safety serves California’s government agencies, departments and offices, as well as clients in its research, education, and healthcare institutio.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
Nanjing NutriHerb BioTech Co. Ltd., founded in 2004 and based in Nanjing, China, is a certified manufacturer specializing in botanical extracts. Its product range includes natural Licorice Extract for health supplements, organic Artemisia Annua Extract used in traditional Chinese medicine, potent antioxidant astaxanthin, Milk Thistle Extract with antioxidant and anti-inflammatory properties, and water-soluble food coloring Sodium Copper Chlorophyllin. These products are certified by Kosher, HALAL, EU, and USDA organic. The company's facility holds approvals from SGS and Bureau Veritas, and it's registered with the FDA, ensuring quality and compliance with international standards.
HiMedia Laboratories Private Limited is a manufacturer of biochemicals, media, and other laboratory consumables that was established in 1975 and is headquartered in Kennett Square, Pennsylvania. Its product range includes bacterial media, cell culture media, biochemicals, enzymes, and reagents. The company's products are used by a number of industries, as diverse as biotechnology, pharmaceutical, diagnostics, and food and beverage industries. HiMedia also provides services to its customers such as custom manufacturing of microbiome sequencing where the company can custom manufacture products to meet the specific needs of its customers.
Chemodex Ltd., established in 2001 and based in St. Gallen, Switzerland, is a manufacturer of fine chemicals, covering different fields such as reagents for life sciences, bioactive molecules, and organic pollutants. The company offers a range of products including fluorescent substances derived from fluorophores such as coumarin, rhodamine, and pyrene. These products are typically used as probes, stains, and in other applications by life-science researchers in academia, biotechnology, and the pharmaceutical industry. Its customer base includes small and medium businesses, large enterprises, as well as academic institutions.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
bioWORLD is a manufacturer and supplier of a wide range of products for life science research. It is headquartered in Dublin,Ohio, and was established in 1993. The company's main products include molecular tools, molecular life sciences reagents, biologicals and pure proteins or enzymes, and lab supplies for bio-medical. Some of its popular products are lectins, glycomatrix, proteins and enzymes. bioWORLD also offers services such as custom training programs and needs assessment. Its products are used by several organizations, including hospitals, public health, commercial laboratories, biotechnology, and pharmaceutical.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Markherb, established in 2013 and based in Kota Bandung, Indonesia, is a manufacturer and supplier of products derived from natural ingredients for the standardization of herbal medicines. The company's product range includes phyllanthin, (±)-catechin, asiaticoside, astragalin, and caffeine. These products are used in the research, development, standardization, and quality control of herbal medicines and natural products. It serves industries such as pharmaceuticals, cosmetics, food, and health. The company also offers services like laboratory analysis, extraction, isolation and structure elucidation, and consulting.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Selleck Chemicals, founded in 2005 in Houston, Texas, USA is a supplier of biotechnology equipment. The company specializes in the supply of small molecule inhibitors, therapeutic antibodies, lab reagents, peptides and compound screening libraries. It supplies over 120,000 inhibitors, required for the study of cell signaling pathways. It helps drug discovery and systems biology researchstudies by supplying High Throughput Screening and High Content Screening equipment. With 10,000 customers on board, the company has headquarters in the United States, Asia, and Europe, and 38 distributors worldwide.
AdooQ BioScience, founded in 2006 and headquartered in Irvine, California, is a supplier specializing in purity inhibitors, chemical probes and reference compounds. The company's product portfolio includes inhibitors for signaling pathways, epigenetics, apoptosis, stem cells, and proteins. These products serve as tools for researchers in academia as well as the biotechnology and pharmaceutical industries, facilitating the execution of experiments, exploration of diseases, and the potential development of treatments and therapies. The company has established over 25 distributors in 30 different countries, along with service networks spanning five continents, thereby ensuring a worldwide reach.
APExBIO Technology LLC is a distributor and supplier of molecular biology tools based in Houston, Texas, United States. The company's product portofolio includes various products such as small molecule inhibitors, compound libraries, fluorescent labels, modified nucleotides, and assay kits. The products are used in various areas such as cancer, immunology, neurosciences, apoptosis, and epigenetics researches. The company offers various supporting services such as analytical services, custom organic synthesis, custom peptide synthesis, and bioinformatics services.
EXTRASYNTHESE, founded in France in 1986, is a supplier of phytochemical analytical standards, ultra-pure chemical substances issued from plants, used to calibrate Quality Control and Research protocols. The company offers samples of more than 850 substances to any industries and academic laboratories dealing with plants or plant based products and serves industries such as healthcare, cosmetics, nutrition, agronomy, and biology. It is also specialized in the extraction, synthesis, biosynthesis, purification, and analysis of phytochemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Nanjing NutriHerb BioTech Co.,Ltd |
20.7%
|
| 2 | Santa Cruz Biotechnology, Inc. |
13.8%
|
| 3 | MP Biomedicals |
10.3%
|
| 4 | Markherb |
6.9%
|
| 5 | HiMedia Laboratories Private Limited |
6.9%
|
| 6 | bioWORLD |
6.9%
|
| 7 | LGC Standards |
6.9%
|
| 8 | GLPBIO Technology LLC |
6.9%
|
| 9 | Chemodex Ltd. |
3.4%
|
| 10 | Biosynth |
3.4%
|
Derivation Method
The ranking is calculated based on the click share within the coumaric acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
7 | 38.9% |
|
Switzerland
|
2 | 11.1% |
|
Japan
|
2 | 11.1% |
|
United Kingdom
|
1 | 5.6% |
|
China
|
1 | 5.6% |
|
India
|
1 | 5.6% |
|
Canada
|
1 | 5.6% |
|
Indonesia
|
1 | 5.6% |
|
Germany
|
1 | 5.6% |
|
France
|
1 | 5.6% |
