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This section provides an overview for phenylalanine as well as their applications and principles. Also, please take a look at the list of 13 phenylalanine manufacturers and their company rankings. Here are the top-ranked phenylalanine companies as of December, 2024: 1.BioCrick, 2.BoxNutra, 3.Parchem.
Table of Contents
Phenylalanine is an essential amino acid known for its role in the biosynthesis of proteins. Characterized by a phenyl group replacing one hydrogen atom in alanine, it exists primarily in the L-form, L-phenylalanine, and is integral to various biological processes.
Found in high-protein foods such as meat, seafood, eggs, and dairy products, phenylalanine is necessary for health but must be consumed in moderation to avoid potential health risks like high blood pressure and heart disease. Individuals with phenylketonuria (PKU), a condition impairing phenylalanine metabolism, must carefully manage their intake to prevent harmful accumulation in the body.
Phenylalanine serves multiple purposes, including the synthesis of the artificial sweetener aspartame, the creation of neurotransmitters like dopamine and noradrenaline, and its application in cosmetics as a moisturizing agent. Its role in neurotransmitter production suggests potential benefits for mood elevation and depression treatment.
This amino acid forms white crystals that are slightly soluble in water but less so in organic solvents. With a melting point of around 283°C and acidic properties in solution, phenylalanine’s chemical behavior is significant for various applications, despite its bitter taste.
The structure of phenylalanine features a benzene ring, distinguishing it from alanine by the substitution of a phenyl group for a hydrogen atom in the side chain, reflecting its name's origin.
Phenylalanine is crucial for synthesizing aspartame and tyrosine, with the latter playing a key role in signaling mechanisms within the body. Phenylketonuria, a genetic condition related to phenylalanine metabolism, underscores the importance of early detection and diet management.
In plants and microorganisms, phenylalanine is produced via the shikimic acid pathway from sugar metabolites, a process not present in mammals. This absence categorizes phenylalanine as an essential amino acid for humans, highlighting the necessity of dietary intake.
*Including some distributors, etc.
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BoxNutra, established in 2021 and based in Tallmadge, Ohio, is a manufacturer and distributor of 600 ingredients. The company’s product portfolio include apple pectin powder, MSM powder, quercetin dihydrate, cissus quadrangularis, and dicalcium phosphate. These products are made from natural ingredients, and are used in a wide range of industries, including fitness and sport, heart health, brain and memory support, immune support, and weight management. The company is ASI cGMPs certified and FDA certified.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Kyowa Hakko Bio Co., Ltd. was established in 2008 and is based in Tokyo, Japan, as a manufacturer of pharmaceutical raw materials and ingredients. It specializes in manufacturing bulk pharmaceuticals like citicoline, L-glutathione, and L-ornithine aspartate. It also manufactures raw materials for infusions, dietary supplements, and cosmetics, such as amino acids, peptides, oligosaccharides, and nucleic acids. The company is a subsidiary of Kirin Holdings Company and has obtained ISO 22000:2018, ISO/TS 22002-1:2009, and FSSC 22000 certifications. Its manufactured products are utilized in pharmaceuticals, nutritional supplements, industrial, and cosmetics sectors across Japan, China, the USA, Germany, and Italy.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Avanschem, established in 2012, a manufacturer of a wide range of products such as cyanuric acid, pegelatinized sarch, welan gum, and more, operating from a prime location of Gurgaon, Haryana, India. The company provides products developed from of top-notch ingredients and industrial chemicals, for lab and Industrial use. These products formulated using chemical compounds under controlled temperature and pressure conditions at their sophisticated laboratory. They specialize in formulations & contract manufacturing, dossiers services, sourcing services and others, with a worldwide distribution network.
Chemodex Ltd., established in 2001 and based in St. Gallen, Switzerland, is a manufacturer of fine chemicals, covering different fields such as reagents for life sciences, bioactive molecules, and organic pollutants. The company offers a range of products including fluorescent substances derived from fluorophores such as coumarin, rhodamine, and pyrene. These products are typically used as probes, stains, and in other applications by life-science researchers in academia, biotechnology, and the pharmaceutical industry. Its customer base includes small and medium businesses, large enterprises, as well as academic institutions.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
SUVCHEM, established in 2004 and headquartered in Mumbai, India, is a manufacturer and exporter of laboratory chemicals and reagents. Their diverse product range includes organic and inorganic chemicals utilized in pharmaceuticals, plastics, water treatment, and more. They also offer biological stains and indicators for laboratory applications like cell culture and DNA analysis, along with culture media ingredients for growing microorganisms. SUVCHEM's products cater to schools, colleges, research laboratories, pharmaceutical and chemical companies, and other industries, supporting teaching, research, product development, and manufacturing processes across various sectors.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Foodchem was founded in 2006 in Shanghai, China. The company is ISO 9001 certified and is a producer, distributor, R&D provider, and marketer of specialty and standard food additives and ingredients to pharmaceutical, cosmetic, nutrition, and chemical industries around the world through distributors and self-managed warehouses. The company operates through four product segments: Food Ingredients, Feed Additives, Industrial Chemicals, and Active Pharmaceutical Ingredients. Certain categories include Kosher and Halal-certified products and products meeting other dietary restrictions.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | BioCrick |
12.0%
|
| 2 | BoxNutra |
10.0%
|
| 3 | Parchem |
10.0%
|
| 4 | KYOWA HAKKO BIO CO.,LTD. |
10.0%
|
| 5 | Chemodex Ltd. |
8.0%
|
| 6 | Foodchem International Corporation |
8.0%
|
| 7 | Avanschem |
8.0%
|
| 8 | Wego Chemical Group Inc |
8.0%
|
| 9 | Junsei Chemical Co.,Ltd. |
8.0%
|
| 10 | Central Drug House |
6.0%
|
Derivation Method
The ranking is calculated based on the click share within the phenylalanine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 33.3% |
|
Japan
|
2 | 22.2% |
|
India
|
2 | 22.2% |
|
Switzerland
|
1 | 11.1% |
|
China
|
1 | 11.1% |
