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This section provides an overview for alanine as well as their applications and principles. Also, please take a look at the list of 7 alanine manufacturers and their company rankings. Here are the top-ranked alanine companies as of December, 2024: 1.KYOWA HAKKO BIO CO.,LTD., 2.Tokyo Chemical Industry Co., Ltd., 3.Cayman Chemical Company.
Table of Contents
Alanine, an amino acid integral to proteins, is known by its IUPAC name (2S)-2-aminopropanoic acid and abbreviated as Ala or A. Produced in the liver and synthesized from pyruvate, this nonessential amino acid is pivotal for energy production, glycogenesis, fatty acid synthesis, and the metabolism of alcohol by aiding in the breakdown of acetaldehyde.
Valued for its umami and sweet flavors, alanine serves as a food additive, enhancing or mitigating flavors in fish paste products, delicacies, pickles, prepared foods, and sake. It also supports alcohol consumption recovery by decomposing acetaldehyde and is believed to aid in hydration and skin health.
As a stabilizing agent, alanine finds application in various formulations, including oral, topical, and injectable pharmaceuticals, contributing to the stability of medicinal compounds.
Alanine, specifically L-alpha-alanine, has a molecular formula of C3H7NO2 and a molecular weight of 89.09, with a CAS number of 56-41-7. It is a white, odorless powder with a sweet taste, showcasing a melting point of 250°C and decomposing at 297°C. Alanine is soluble in water and slightly soluble in ethanol, while nearly insoluble in organic solvents like diethyl ether and acetone.
While L-alpha-alanine is the most common form, D-alpha-alanine and beta-alanine also exist, each with unique properties and applications. Beta-alanine, notably different in its amino group's position, lacks an enantiomer and serves in various biochemical roles.
Alanine production involves asymmetric hydrolysis by microbial enzymes or enzymatic decarboxylation, with methods such as Strecker Amino Acid Synthesis also employed for its synthesis.
When dealing with alanine, avoid strong oxidizing agents and ensure proper protective measures are in place. In case of fire, skin contact, eye contact, or ingestion, follow recommended safety procedures. For storage, keep alanine in a cool, dark place within appropriate containers.
*Including some distributors, etc.
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Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Kyowa Hakko Bio Co., Ltd. was established in 2008 and is based in Tokyo, Japan, as a manufacturer of pharmaceutical raw materials and ingredients. It specializes in manufacturing bulk pharmaceuticals like citicoline, L-glutathione, and L-ornithine aspartate. It also manufactures raw materials for infusions, dietary supplements, and cosmetics, such as amino acids, peptides, oligosaccharides, and nucleic acids. The company is a subsidiary of Kirin Holdings Company and has obtained ISO 22000:2018, ISO/TS 22002-1:2009, and FSSC 22000 certifications. Its manufactured products are utilized in pharmaceuticals, nutritional supplements, industrial, and cosmetics sectors across Japan, China, the USA, Germany, and Italy.
Nutricia Limited was established in 1896 and is headquartered in Watford, England as a healthcare company specializing in medical nutrition products. The company is a manufacturer of infant formula and other nutritional products, including milk-based formula, soy-based formula, and hypoallergenic formula. Nutricia Limited offers a wide range of medical nutrition solutions for various conditions such as infant nutrition, metabolic disorders, and malnutrition. Its products cater to healthcare professionals and patients with specific dietary needs. The company is devoted to providing essential nutritional support, technical support, installation, and raining while enhancing patient well-being and recovery.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Tokyo Chemical Industry Co., Ltd. |
20.7%
|
| 2 | KYOWA HAKKO BIO CO.,LTD. |
20.7%
|
| 3 | Cayman Chemical Company |
13.8%
|
| 4 | Toronto Research Chemicals |
13.8%
|
| 5 | Nutricia Limited |
10.3%
|
| 6 | Carl Roth GmbH + Co. KG |
10.3%
|
| 7 | nacalai |
10.3%
|
Derivation Method
The ranking is calculated based on the click share within the alanine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
3 | 50.0% |
|
United States of America
|
1 | 16.7% |
|
Canada
|
1 | 16.7% |
|
Germany
|
1 | 16.7% |
