This section provides an overview for lithium aluminum hydride as well as their applications and principles. Also, please take a look at the list of 17 lithium aluminum hydride manufacturers and their company rankings. Here are the top-ranked lithium aluminum hydride companies as of December, 2023: 1.naugraexport.
Figure 1. Basic information on lithium aluminum hydride
Lithium Aluminum Hydride is an inorganic compound with the composition LiAlH4.
It is also known as Lithium Aluminum Hydride and is commonly abbreviated as LAH (lithium aluminium hydride).
Lithium Aluminum Hydride is a potent reducing agent and is classified by the GHS as a water-reactive flammable chemical, skin corrosive/irritant, acute toxic (oral), toxic to reproduction, and eye irritant. Lithium Aluminum Hydride is classified as a hazardous and toxic substance under the Industrial Safety and Health Law, which requires labeling and notification of names, etc., and as Class III under the Fire Service Law.
Lithium Aluminum Hydride is used as a reducing agent in chemical synthesis. It is frequently used in the laboratory due to its high reactivity. However, on an industrial scale, reductants with milder reactivity are used and are often avoided for safety reasons.
It is mainly used to reduce esters and carboxylic acids to primary alcohols, using dehydrated ether as the reaction solvent.
Lithium Aluminum Hydride has a molar mass of 37.954 g/mol and a density of 0.917 g/cm3.
It is a stronger reducing agent than sodium borohydride (NaBH4) because the B-H bond is stronger than the Al-H bond. Lithium Aluminum Hydride reacts violently with water to produce hydrogen. A dehydrating solvent is required for use.
Lithium Aluminum Hydride is a hydride complex of aluminum. It is an ionic crystal composed of aluminum hydride ions (AlH-) and lithium ions (Li+), and its crystal structure belongs to the monoclinic system. AlH4- has a tetrahedral structure, and the Al-H bond distance in the crystal is approximately 1.55 Å.
The reaction of aluminum chloride (AlCl3) with lithium hydride (LiH) yields lithium aluminum hydride. The yield by weight is 97%. The reaction mixture can be dissolved in ether and the remaining solid lithium chloride (LiCl) removed by filtration.
Figure 2. Decomposition reaction of lithium aluminum hydride
Lithium Aluminum Hydride is a strong base. Therefore, it reacts violently with protic solvents such as alcohol and decomposes.
At room temperature, Lithium Aluminum Hydride is metastable. After prolonged storage, it gradually decomposes to Li3AlH6 and LiH. The decomposition is accelerated in the presence of titanium, iron, and vanadium.
Lithium Aluminum Hydride decomposes with sodium hydride in tetrahydrofuran (THF) to give sodium aluminum hydride (NaAlH4). Similarly, potassium aluminum hydride (KAlH4) can be produced in 90% yield.
The reverse reaction of NaAlH4 and KAlH4 with lithium chloride to lithium Aluminum Hydride also proceeds using diethyl ether or tetrahydrofuran as the solvent.
Otherwise, lithium aluminum hydride reacts with magnesium bromide (MgBr2) to magnesium aluminum hydride, Mg(AlH4)2.
Figure 3. Reaction mechanism of lithium aluminum hydride
In organic chemistry, lithium aluminum hydride is very reactive and can be used as a powerful reducing agent. In particular, the reduction of esters and carboxylic acids to primary alcohols is widely used.
In this reduction reaction, the hydride ion, H-, attacks the active center of organic compounds with low electron density due to the induced and mesomeric effects along with the decomposition of AlH4-.
*Including some distributors, etc.
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Stanford Advanced Materials was established in 1994 in Lake Forest, California to provide rare-earth products for research and development purposes. Stanford Advanced Materials serves many industries ranging from automotive to fashion to energy to research to sports to textiles. Stanford Advanced Materials manufactures and distributes purified metals, ceramics, composite materials including strips, plates, rods, wires, and bars, as well as laboratory equipment and optical equipment including crystals, lenses, splitters, and windows.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Powder Pack Chem was founded in 2001 and is headquartered in Mumbai, Maharashtra, India. The company is a manufacturer and exporter of specialty chemicals used in pharmaceuticals, fashion, and beauty products. The company offers hundreds of products available in volumes ranging from 100 grams to 500 kilograms. The company services include providing on-time consignments for customers in need of quick delivery. Chemicals range from acacia gum powder all the way to three variations of zinc sulphate.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Dubi Chem was founded in 1995 and is headquartered in the United Arab Emirates. The company is a marine chemical manufacturer based in Asia, serving marine, oilfield, water treatment, automotive, and shipping industries. The company’s product list includes hundreds of chemicals and finished products, ranging from wheel cleaners to skin care pastes to oil drilling chemicals. The company provides services such as inspections and cleaning specialists who provide dedicated tank cleanings preloading and post-delivery, logistics services, and private labeling options for OEMs and other manufacturers to self-label.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
naugraexport was established in 1951 and is a distributor and supplier of lab equipments based in Ambala Cantt, Haryana, India. The company's product portofolio offers various products such as zoom stereo binocular microscope, human anatomy models, flask erlenmeyer narrow neck glass, laser theodolite, and precision engineered cube mould. The products are used in various industries such as petrochemical, agriculture, semiconductor manufacture, pharmaceutical, and energy. The company has obtained the certificate of ISO 9001:2008 certification standards.
Tianjin Daofu Chemical New Technology Development Co. Ltd., founded in Cangzhou City, China in 1999, is a manufacturer of fine chemicals. The company produces a series of hydrides and deuterides, including lithium tri-test-butoxy aluminum hydride, lithium borohydride, zinc borohydride, lithium triethyl borohydride, and lithium tri-sec-butyl borohydride. Its products find application in industries such as pharmaceutical, manufacturing, and biotech. It also offers custom synthesis services, tailoring fine chemicals to meet unique requirements.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.