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This section provides an overview for barbituric acids as well as their applications and principles. Also, please take a look at the list of 18 barbituric acid manufacturers and their company rankings. Here are the top-ranked barbituric acid companies as of December, 2024: 1.Explicit Chemicals Pvt. Ltd., 2.AVA Chemicals Private Limited, 3.Vizag Chemical Internacional.
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Okayama University Graduate School, Ph.D. (Agriculture). After working as a specially appointed Assistant Professor at Tokyo Medical and Dental University, a fluid researcher at the Okayama Prefectural Institute of Biological Sciences, and a special researcher (JSPS PD) at the Japan Society for the Promotion of Japan Science, he became independent as a freelancer.
Specializes in natural product chemistry, protein engineering, fermentation engineering, and instrumental analysis of chemicals (especially mass spectrometry chemistry).
Thesis: https://pubmed.ncbi.nlm.nih.gov/?term=HIROKAZU+USUKI
linkedin: https://www.linkedin.com/in/%E5%8D%9A%E4%B8%80-%E8%87%BC%E6%9C%A8-b83827228/
Barbituric acid, a heterocyclic compound with a pyrimidine skeleton, is also known as malonyl uric acid. Discovered by Adolf von Beyer, it is a colorless, odorless solid synthesized by dehydrating malonic acid and urea under acidic conditions, with diethyl malonate currently used in its synthesis.
1. Name:
English Name: Barbituric Acid
IUPAC Name: 1,3-diazinane-2,4,6-trione
2. Molecular Formula:
C4H4N2O3
3. Melting Point:
245°C (decomposes)
4. Solubility:
Slightly soluble in water and ethanol, insoluble in ether, soluble in hot water
Barbiturates, derivatives of barbituric acid, have central nervous system depressant effects. Notable examples include barbital, phenobarbital, amobarbital, allobarbital, cyclobarbital, pentobarbital, thiopentanal, thiaminal, and hexobarbital. Barbituric acid itself, however, lacks CNS depressant effects.
Barbiturates bind to GABAA receptors, open chloride channels, and enhance inhibitory nerve function by depolarizing synaptic membranes.
Barbiturates were the primary sedatives and sleeping pills until the 1950s but have been largely replaced by benzodiazepine derivatives due to risks of dependence, withdrawal symptoms, and vitamin deficiencies. Currently, their use is limited to a few applications such as euthanasia and epilepsy treatment.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
AVA Chemicals Private Limited (ACP) is an Indian manufacturer of industrial chemicals founded in 1985 in Mumbai, Maharashtra. The company offers various chemical products including chelating and sequestering agents, acetates, chlorides, and nitrates. These are available in different grades, and have applications in pharmaceuticals, agricultural products, water treatment, and laboratory research projects. ACP products are mainly used by clients in the agrochemical, pharmaceutical, petrochemical, and water treatment sectors, which it serves alongside its sister company AVA Lifesciences Private Limited.
A.B. Enterprises was established in 1984 and is headquartered in Maharashtra, India. The company is a manufacturer and supplier of general chemicals, specialties, and industrial chemicals to a broad range of industries including food, textile, plastic, rubber, and other industries. The company exports primarily to Canada, Bahrain, and Dubai. The company’s five major product segments include petrochemicals, food chemicals, laboratory chemicals, water treatment chemicals, and fine chemicals. In addition, the company manufactures dentistry materials, pesticides, and chemical supplies.
Shri Rajaram Chemicals & Engg, founded in Pune, Maharashtra, in 2011 is a manufacturer and supplier of Pharmaceutical Chemicals, Fine Chemicals, Laboratory Chemicals & Agricultural Goods. The company's product portfolio includes Fresh Ginger, Dry Ginger Dimethyl Isosorbide, Anthrone, Thiomalic Acid and N-(1-Naphthyl)-Ethylenediamine Dihydrochloride. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. They export to Europe, America, Africa, the Middle East and Australia.
Explicit Chemicals Pvt. Ltd., founded in India, is a manufacturer of drug intermediates and specialty chemicals like sodium lauryl sulfate, barbituric acid, alloxan, and monohydrate. The company's product portfolio includes specialty chemicals that span various applications, including agrochemicals, dyes, polymers, and more. It also offers custom synthesis services, allowing clients to request the development of proprietary chemical compounds tailored to their unique requirements. The company serves markets such as pharmaceutical, chemical manufacturing, and agrochemicals.
Alpha Chemika, founded in 1989 and based in Mumbai, India, is a manufacturer, supplier of laboratory reagents and fine chemicals. Their products are used in multiple industries, including pharmaceutical, chemical, biotechnology, and environmental. Their product portfolio ranges from chemicals such as Silver Nitrate, Perchloric Acid, and Lanthanum Acetate to laboratory tools and equipment such as Air Inlet Tubes, Air Inlet Tubes, and Optical Components. Alpha Chemika has been able to obtain ISO 9001:2000 certification.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Westindiachemical, established in 1995, and headquartered in Gandhidham, India, is a manufacturer and supplier of marine chemicals, water treatment chemicals, and industrial chemicals. Its marine chemicals safeguard vessels and equipment, water treatment solutions purify water for safe use, and industrial chemicals facilitate processes in manufacturing, textiles, and more. Among their products, Corrosion Inhibitor for Central Air Chiller shields heat exchangers, Polish Preparation for Metal readies surfaces for coating, and Hold Solution aids in paint drying. Additionally, they offer Sodium Perborate Tetrahydrate for bleaching and Potassium Chloride for water softening and de-icing.
SUVCHEM, established in 2004 and headquartered in Mumbai, India, is a manufacturer and exporter of laboratory chemicals and reagents. Their diverse product range includes organic and inorganic chemicals utilized in pharmaceuticals, plastics, water treatment, and more. They also offer biological stains and indicators for laboratory applications like cell culture and DNA analysis, along with culture media ingredients for growing microorganisms. SUVCHEM's products cater to schools, colleges, research laboratories, pharmaceutical and chemical companies, and other industries, supporting teaching, research, product development, and manufacturing processes across various sectors.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
East India Chemicals (EIC) is an Indian supplier and distributor of industrial chemicals that was established in 2008. Based in Kolkata, the company primarily offers chemicals for use in marine applications, such as biocides, degreasers, antifouling agents, and oil spill dispersants. It also offers other industrial chemicals including surfactants and solvents, as well as specialty chemicals such as polymers, lubricants, and adhesives. EIC primarily serves clients in marine and wastewater operations, as well as in the rubber, textile, and agricultural industries.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | AVA Chemicals Private Limited |
12.1%
|
| 2 | Explicit Chemicals Pvt. Ltd. |
10.3%
|
| 3 | Vizag Chemical Internacional |
10.3%
|
| 4 | LobaChemie Pct.Ltd. |
10.3%
|
| 5 | Otto Chemie Pvt. Ltd |
6.9%
|
| 6 | Merck |
6.9%
|
| 7 | Alpha Chemika |
5.2%
|
| 8 | A. B. Enterprises |
5.2%
|
| 9 | Central Drug House |
5.2%
|
| 10 | MilliporeSigma |
5.2%
|
Derivation Method
The ranking is calculated based on the click share within the barbituric acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
8 | 61.5% |
|
Japan
|
4 | 30.8% |
|
United Kingdom
|
1 | 7.7% |
