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This section provides an overview for uric acid as well as their applications and principles. Also, please take a look at the list of 11 uric acid manufacturers and their company rankings. Here are the top-ranked uric acid companies as of December, 2024: 1.Molekula Americas LLC, 2.KANTO CHEMICAL CO.,INC., 3.Alfa Chemistry.
Table of Contents
Uric acid is an organic compound with the chemical formula C5H4N4O3, having a molecular weight of 168.11. Also known as 2,6,8-trihydroxypurine, it appears as a white to slightly light brown powder and is insoluble in water. It is excreted as a nitrogen metabolism end product in birds, reptiles, and insects, and to a lesser extent in human urine as a nucleic acid metabolism product. Initially discovered in bladder stones, uric acid's CAS number is 69-93-2 and is not classified as hazardous according to GHS criteria.
Uric acid has applications in research and pharmaceutical fields. The blood uric acid level serves as an indicator of hyperuricemia, a condition arising from the body's difficulty in excreting uric acid or overproduction. High purine intake can also elevate this risk. Hyperuricemia is diagnosed when uric acid levels exceed 7.0 mg/dL, while levels below 2 mg/dL indicate hypouricemia, a condition of excessive uric acid excretion or underproduction.
Uric acid's melting point exceeds 300°C. It is soluble in sodium hydroxide solutions but insoluble in ethanol and ether. The murexide reaction, turning an aqueous uric acid solution reddish-purple upon adding nitric acid and ammonia, confirms its presence. Excessive accumulation leads to urate crystal formation, triggering gout attacks. While uric acid acts as an antioxidant, it can promote oxidation under certain conditions.
Commercially, uric acid is available in various amounts, including 10 g, 25 g, 100 g, 500 g, and 1 kg options.
Uric acid biosynthesis involves xanthine dehydrogenase, starting from ribose-5-phosphate to xanthine. The body's production pathways are split into exogenous (dietary purines) and endogenous (cellular metabolism of nucleic acids and ATP), contributing to approximately 20-30% and 70-80% of produced uric acid, respectively. Daily human uric acid production is about 0.6 grams.
Gout, characterized by uric acid crystal deposition in joints, leads to recurrent arthritis. It commonly affects the toes, insteps, knees, and elbows, among other joints. Gouty nodules, resulting from uric acid deposits, frequently occur on fingers, hands, feet, and elbows, and can also affect kidneys and the skin beneath the ears, potentially causing urinary tract stones in patients.
Epidemiological studies suggest a link between high uric acid levels and increased arteriosclerosis risk. Since 2020, uric acid salt deposition in arterial walls has been documented, potentially damaging vessel cells and contributing to atherosclerosis.
*Including some distributors, etc.
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Thermo Fisher Scientific Inc., founded in 1956 and headquartered in Waltham, Massachusetts, is a manufacturer and supplier of life science solutions, analytical instruments, specialty diagnostics, laboratory products, and biopharma services. Through its brand names, including Invitrogen, Fisher Scientific, Patheon, Applied Biosystems, and Gibco, among others, the company provides a wide range of products, which include chromatography systems, thermal cyclers, automated cell counters, fermenters, and DNA polymerases. The company’s annual revenue is over 40 billion USD, and it serves several fields, including customers working in clinical diagnostic labs, research institutions, hospitals, government agencies, and pharmaceutical/biotech companies.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Molekula Americas LLC |
30.8%
|
| 2 | KANTO CHEMICAL CO.,INC. |
30.8%
|
| 3 | Alfa Chemistry |
15.4%
|
| 4 | Thermo Fisher Scientific Inc. |
15.4%
|
| 5 | FUJIFILM Wako Pure Chemical Corporation |
7.7%
|
Derivation Method
The ranking is calculated based on the click share within the uric acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 44.4% |
|
United States of America
|
2 | 22.2% |
| United States | 1 | 11.1% |
|
Canada
|
1 | 11.1% |
|
United Kingdom
|
1 | 11.1% |
