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This section provides an overview for pentobarbital as well as their applications and principles. Also, please take a look at the list of 8 pentobarbital manufacturers and their company rankings. Here are the top-ranked pentobarbital companies as of December, 2024: 1.PEACEFULEXIT, 2.MilliporeSigma, 3.Akorn.
Table of Contents
Pentobarbital, known as Nembutal among other names, is a white powder organic compound used primarily in the medical field. Classified under various safety regulations due to its potent effects and potential hazards, it has seen restricted use over the years.
Historically used as a sedative-hypnotic, pre-anesthetic, and for treating insomnia, pentobarbital's usage has diminished due to safety concerns. It has also been used for euthanasia in some countries and as an animal anesthetic and euthanasia drug.
With a chemical formula of C11H18N2O3, pentobarbital is notable for its solubility in water and ethanol, and its stability in various forms. It decomposes in water and has specific physical characteristics, such as a melting point of 130°C and a molecular weight of 226.27.
Sold primarily as a sodium salt, pentobarbital is part of the barbiturate class of drugs, characterized by a distinct chemical structure that includes a barbituric acid core.
Common side effects include dizziness, nausea, and headache. It's contraindicated for patients with certain conditions like bronchial asthma. Handling precautions emphasize avoiding oxidizing agents and ensuring proper storage away from direct sunlight.
Pentobarbital can be synthesized through various chemical reactions, involving compounds like ethyl 1-methylbutyl cyanoacetate. It's regulated under laws concerning ship safety, civil aeronautics, and controlled substances, reflecting its potent effects and potential for misuse.
The sodium variant of pentobarbital, with a molecular weight of 248.25, is used in medical applications where solubility in water is required. Its hygroscopic nature and solubility characteristics are key for its pharmaceutical formulations.
*Including some distributors, etc.
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Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Tocris Bioscience, trading as Tocris Cookson Ltd., established in 1982 and headquartered in Bristol, UK, is a supplier of life science reagents. Its extensive product range encompasses receptor agonists and antagonists, enzyme inhibitors, ion channel modulators, fluorescent probes and dyes, along with PROTAC Degraders for targeted protein degradation. The compay has received several accolades, including The Queen's Awards for Enterprise in International Trade. The company is part of the life science division of Bio-Techne, which also includes class brands R&D Systems, Novus Biologicals, ProteinSimple and Advanced Cell Diagnostics.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MilliporeSigma |
34.6%
|
| 2 | PEACEFULEXIT |
21.9%
|
| 3 | Akorn |
9.1%
|
| 4 | Sagent Pharmaceuticals |
8.1%
|
| 5 | BioCrick |
7.6%
|
| 6 | Virbac |
6.6%
|
| 7 | nacalai |
6.1%
|
| 8 | Tocris Bioscience |
6.0%
|
Derivation Method
The ranking is calculated based on the click share within the pentobarbital page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
United States of America
|
2 | 66.7% |
|
Japan
|
1 | 33.3% |
