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This section provides an overview for malonic acids as well as their applications and principles. Also, please take a look at the list of 41 malonic acid manufacturers and their company rankings. Here are the top-ranked malonic acid companies as of December, 2024: 1.SimSon Pharma Limited, 2.Molekula Americas LLC, 3.Spectrum Chemical Mfg. Corp..
Table of Contents
Malonic acid is a dicarboxylic acid characterized by two carboxylic groups (-COOH). In its salt form, it is known as malonate. Derived from the Greek word for apple, the CAS registration number for malonic acid is 141-82-2.
For safe storage, malonic acid should be kept in a cool, well-ventilated place away from direct sunlight. Glass is recommended as a safe container and packaging material.
Malonic acid, found in apples, is used as a flavoring agent in the medical field and others. Its carboxyl group also makes it valuable in the synthesis of resins and adhesives.
Malonic acid appears as a white or almost white crystalline powder. It has a melting point of 275°F (135°C) and is solid at room temperature and pressure. Upon heating to slightly above its melting point, it decomposes into acetic acid and carbon dioxide. Malonic acid is soluble in water, ethanol, and acetone.
With the chemical formula HOOCCH2COOH, malonic acid has a molecular weight of 104.06. It is part of the acetic acid-malonic acid metabolic pathway.
Malonic acid's diester is an active methylene compound. The methylene proton can be readily abstracted by a base to form a carbanion, which is useful in forming carbon-carbon bonds.
Malonic acid's structure closely resembles succinic acid (HOOC-(CH2)2-COOH). It can bind to the active site of succinate dehydrogenase in the citric acid cycle, inhibiting the metabolism of succinate and thereby interfering with cellular respiration.
Elevated levels of malonic acid, along with methylmalonic acid, may indicate a metabolic disorder known as combined malonic and methylmalonic aciduria. This condition can be distinguished from classical methylmalonic aciduria by analyzing the ratio of malonic acid to methylmalonic acid in plasma.
Malonic ester synthesis is a method for obtaining α-substituted acetic esters using carbanions generated from malonic acid esters. This synthesis provides a synthetic advantage in forming C-C bonds without the need for strong acids or bases.
In this synthesis, a base is added to a malonic acid ester to generate a carbanion, which is stabilized by resonance with two carbonyl groups. Reacting this carbanion with an alkyl halide (R-X) and treating it with a dilute acid, if necessary, allows for easy hydrolysis and decarboxylation, yielding an α-substituted ester.
Malonic acid ester synthesis is similar to acetoacetic acid ester synthesis.
*Including some distributors, etc.
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AccuStandard, established in 1986 and headquartered in New Haven, Connecticut, USA, is a manufacturer of Certified Reference Materials (CRMs). The offered products include organic standards, inorganic standards, custom standards, proficiency testing materials, and calibration kits. These products are used to ensure the accuracy, precision, and reliability of analytical methods and instruments in various industries such as environmental, pharmaceutical, food, petrochemical, and forensic. Its products meet stated specifications and comply with international standards, including ISO 17034:2016, ISO/IEC 17025:2017, and ISO 9001:2015.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
United States Biological, located in Salem, Massachusetts, is a manufacturer and supplier of life science research products. Its product offerings include biochemicals, antibodies, and molecular biology kits. The company’s products are used in various fields such as genomic research, biotechnology, and pharmaceutical development. Products are available from affordable research quantities to larger bulk amounts for process development and production. Its customer base comprises pharmaceutical and biotechnology companies both in the US and overseas.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
CPAChem Ltd, founded in 2001 and based in Bogomilovo, Bulgaria, is a manufacturer of organic and inorganic custom-made certified reference materials as well as pharmacopoeia products and Analytical CRMs. With the capability to produce more than 200 different products daily, it stands as the sole global producer offering products in accordance with seven different pharmacopoeias, including the Japanese, Indian, and British pharmacopoeias. The company boasts a catalog of over 9,000 stock products, serving clients such as Carlo Erba, Fisher, and VWR. It holds ISO 9001 certification and has achieved accreditation in ISO/IEC 17025 and ISO 17034.
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd, established in 2013 and headquartered in Hefei City, China, is a manufacturer specializing in both standard and custom chemical synthesis. With manufacturing facilities in Anhui, Jiangsu, Zhejiang, and Inner Mongolia, Home Sunshine Pharma offers a range of products, including active pharmaceutical ingredients (APIs), intermediates, fine chemicals, coenzymes, and nucleotides. As an ISO 9001:2015 certified company, Home Sunshine Pharma serves research institutions, universities, and industries in Europe, America, and Southeast Asia with their chemical products.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Biozol Diagnostica Vertrieb GmbH, founded in 1989 and based in Eching, Germany is a manufacturer and service provider of life sciences, diagnostics and pharmaceutical industry. The company produces antibiotics, PCR reagents, blocking peptides, biochemicals and kits for the direct conjugation of antibodies to oligonucleotides. It is also popular for its biomedical services such as antibody protection recombinant protein expression, seleno protein production and ELISA development. All the products are guaranteed by ISO:9001 and TÜV Rheinland certified quality management system.
bioWORLD is a manufacturer and supplier of a wide range of products for life science research. It is headquartered in Dublin,Ohio, and was established in 1993. The company's main products include molecular tools, molecular life sciences reagents, biologicals and pure proteins or enzymes, and lab supplies for bio-medical. Some of its popular products are lectins, glycomatrix, proteins and enzymes. bioWORLD also offers services such as custom training programs and needs assessment. Its products are used by several organizations, including hospitals, public health, commercial laboratories, biotechnology, and pharmaceutical.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
KEDACOM was established in 1995 and is a manufacturer and supplier of video products and solutions based in Suzhou, China. The company offers various video-related products such as IR bullet camera, explosion proof camera, face recognition terminal, rack mount terminal, and smart meeting board. The products are used in various applications such as education, police station, crime investigation, and road monitoring. The company has involved in various projects in various countries, such as surveillance system for Ankara University, first line of defense for Phuket Island, unified security management for Aseana City in the Philippines, and Tsinghua University education solution.
Alfa Chemical Co., Ltd., founded in 1973 and headquartered in Zhengzhou, India, is a manufacturer and supplier of organic chemicals for researching, development and manufacturing. The company provides scientific analytical chemicals, material science and life science chemicals, and catalysts from grams to kilograms. These chemicals include building blocks, reagents, pharmaceutical intermediates, dyes & indicators, produced by standards and analytical methods such as NMR, HPLC and MS. The company has a production facility, test laboratories and research centers, and provides packaging and delivery services.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
LARODAN AB is a provider of lipids and related products for research and industrial applications. With its headquarters in Malmö, Sweden, the company was established in 1963. LARODAN specializes in producing a wide range of lipids, including fatty acids, liposomes, and lipid standards. These products serve various sectors such as pharmaceuticals, life sciences, and food industries. The company offers services such as Packaging, delivery, Certificates of analysis, high-purity lipids, customized solutions, and technical expertise.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
APExBIO Technology LLC is a distributor and supplier of molecular biology tools based in Houston, Texas, United States. The company's product portofolio includes various products such as small molecule inhibitors, compound libraries, fluorescent labels, modified nucleotides, and assay kits. The products are used in various areas such as cancer, immunology, neurosciences, apoptosis, and epigenetics researches. The company offers various supporting services such as analytical services, custom organic synthesis, custom peptide synthesis, and bioinformatics services.
Moldb, based in Hangzhou, China, is a supplier of building blocks and advanced intermediates. The company also offers a catalogue of products, including inhibitors and agonists, amino acids and peptides, catalysts and ligands, natural products, and nucleotides. The company delivers expert services and the finest products to users in the chemical and pharmaceutical R&D fields. It adheres to ISO 9001's quality management system. The companies’ analytical labs have various equipment such as GCs, HPLCs, LC-MS, TLC-MS, MS, NMR etc.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Yuanfar International Trade Company, established in 2001 and headquartered in Xi'an, Shaanxi, China, is a distributor of nonferrous metals, chemicals, and solar-photovoltaic products while providing professional foreign trade supply chain services. Its product range includes chemicals like Hydrazine hydrate, Mono-methyl hydrazine, DMF, Acetonitrile, and Fluorine products, serving diverse industries and exporting to countries such as Europe, the USA, India, and Japan. With two decades of experience, the company has cultivated strong partnerships with chemical companies in China, contributing to global trade.
Boreal Science, launched way back in 1955 in St. Catharines, Ontario, Canada is a supplier of lab equipment and supplies. The company specializes in books, charts, models, equipment and computer software for subjects like biology, physics, chemistry, forensic science, environmental science and earth science or geology. It is the ultimate solution provider for classroom teaching aids and equipment. Its easy-to-use lab kits, learning resources, data sheets and teaching materials help to make the teaching of these subjects easy and effective.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | SimSon Pharma Limited |
21.9%
|
| 2 | Molekula Americas LLC |
12.5%
|
| 3 | Spectrum Chemical Mfg. Corp. |
12.5%
|
| 4 | AccuStandard |
9.4%
|
| 5 | Alfa Chemistry |
9.4%
|
| 6 | LobaChemie Pct.Ltd. |
6.3%
|
| 7 | Alfa Aesar, Thermo Fisher Scientific. |
6.3%
|
| 8 | FUJIFILM Wako Pure Chemical Corporation |
6.3%
|
| 9 | SIR SAFETY SYSTEM S.P.A. |
3.1%
|
| 10 | SRL |
3.1%
|
Derivation Method
The ranking is calculated based on the click share within the malonic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
China
|
7 | 21.2% |
|
Japan
|
5 | 15.2% |
|
United States of America
|
4 | 12.1% |
|
India
|
4 | 12.1% |
|
United Kingdom
|
4 | 12.1% |
| United States | 1 | 3.0% |
|
Bulgaria
|
1 | 3.0% |
|
Switzerland
|
1 | 3.0% |
|
Canada
|
1 | 3.0% |
|
Germany
|
1 | 3.0% |
Italy
|
1 | 3.0% |
Poland
|
1 | 3.0% |
|
Sweden
|
1 | 3.0% |
France
|
1 | 3.0% |
