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This section provides an overview for inosine as well as their applications and principles. Also, please take a look at the list of 10 inosine manufacturers and their company rankings. Here are the top-ranked inosine companies as of December, 2024: 1.Ennore India Chemicals, 2.Central Drug House, 3.AdvaCare Pharma USA.
Table of Contents
Inosine is an organic compound with the chemical formula C10H12N4O5, also known as hypoxanthosine or hypoxanthine riboside. It is an N-riboside consisting of hypoxanthine (6-hydroxypurine) and D-ribose. Its CAS registry number is 58-63-9.
With a molecular weight of 268.23, a melting point of 226°C, and a nearly white crystalline powder form at room temperature, inosine is soluble in water and has a solubility of 1.6g/100mL at 20°C. However, it is practically insoluble in ethanol.
Inosine has various applications in the medical and food industries. It's a component of umami flavor and is used in the treatment of radiation exposure, drug-induced leukopenia, and subacute sclerosing panencephalitis. Additionally, inosine is used as a dietary supplement for its potential to activate the ATP cycle and enhance endurance.
Biochemically, inosine is a trace base rarely found in RNA but often present in tRNA, especially in the anticodon site. It can be associated with various nucleobases through hydrogen bonds. Inosine is abundant in muscle tissue and undergoes hydrolysis into hypoxanthine and D-ribose when heated in dilute sulfuric acid.
Inosine products include pharmaceuticals, supplements, and research reagents, available in capacities suitable for laboratory and industrial applications. They are typically handled at room temperature.
Inosine can be obtained by fermenting adenosine with adenosine deaminase and is also produced by the degradation and synthesis of inosinic acid.
Inosinic acid, with phosphate at the 5' position of the ribose moiety in inosine, is a tastant nucleotide found in meat. The sodium salt of inosinic acid is a key umami compound in dried bonito flakes. In vivo, inosine is synthesized from xanthine and converted to inosinic acid via the salvage pathway.
*Including some distributors, etc.
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AdvaCare Pharma USA LLC, founded in 2014, is an American pharmaceutical manufacturer and supplier based in Cheyenne, Wyoming. The company specializes in a wide range of products, including over-the-counter (OTC) medicines, supplements, antimalarial tablets, injections, and oral suspensions. They also offer oncology tablets, injections, and powder for injections, as well as veterinary products and medical devices like injection instruments, diagnostic detection instruments, and skin and wound care products. AdvaCare's products are available under various brands, such as AmoxiCare™ for amoxicillin capsules and AdvaLife™ for supplements.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Alpha Chemika, founded in 1989 and based in Mumbai, India, is a manufacturer, supplier of laboratory reagents and fine chemicals. Their products are used in multiple industries, including pharmaceutical, chemical, biotechnology, and environmental. Their product portfolio ranges from chemicals such as Silver Nitrate, Perchloric Acid, and Lanthanum Acetate to laboratory tools and equipment such as Air Inlet Tubes, Air Inlet Tubes, and Optical Components. Alpha Chemika has been able to obtain ISO 9001:2000 certification.
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd, established in 2013 and headquartered in Hefei City, China, is a manufacturer specializing in both standard and custom chemical synthesis. With manufacturing facilities in Anhui, Jiangsu, Zhejiang, and Inner Mongolia, Home Sunshine Pharma offers a range of products, including active pharmaceutical ingredients (APIs), intermediates, fine chemicals, coenzymes, and nucleotides. As an ISO 9001:2015 certified company, Home Sunshine Pharma serves research institutions, universities, and industries in Europe, America, and Southeast Asia with their chemical products.
Ennore India Chemicals, established in 1995, and based in Tamil Nadu, India, is a manufacturer and supplier of industrial chemicals and cleaning solutions. The company serves various industries, including wastewater treatment, marine, power generation, and oil and gas. Ennore India Chemicals also provides fuel additives, corrosion inhibitors, descaling chemicals, chemicals for boiler water treatment, as well as chemicals for cooling towers. Their ISO 9001:2015 certification guarantees quality goods and environmentally friendly practices.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
SUVCHEM, established in 2004 and headquartered in Mumbai, India, is a manufacturer and exporter of laboratory chemicals and reagents. Their diverse product range includes organic and inorganic chemicals utilized in pharmaceuticals, plastics, water treatment, and more. They also offer biological stains and indicators for laboratory applications like cell culture and DNA analysis, along with culture media ingredients for growing microorganisms. SUVCHEM's products cater to schools, colleges, research laboratories, pharmaceutical and chemical companies, and other industries, supporting teaching, research, product development, and manufacturing processes across various sectors.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Foodchem was founded in 2006 in Shanghai, China. The company is ISO 9001 certified and is a producer, distributor, R&D provider, and marketer of specialty and standard food additives and ingredients to pharmaceutical, cosmetic, nutrition, and chemical industries around the world through distributors and self-managed warehouses. The company operates through four product segments: Food Ingredients, Feed Additives, Industrial Chemicals, and Active Pharmaceutical Ingredients. Certain categories include Kosher and Halal-certified products and products meeting other dietary restrictions.
East India Chemicals (EIC) is an Indian supplier and distributor of industrial chemicals that was established in 2008. Based in Kolkata, the company primarily offers chemicals for use in marine applications, such as biocides, degreasers, antifouling agents, and oil spill dispersants. It also offers other industrial chemicals including surfactants and solvents, as well as specialty chemicals such as polymers, lubricants, and adhesives. EIC primarily serves clients in marine and wastewater operations, as well as in the rubber, textile, and agricultural industries.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Ennore India Chemicals |
18.2%
|
| 2 | Central Drug House |
13.6%
|
| 3 | AdvaCare Pharma USA |
13.6%
|
| 4 | SUVCHEM |
11.4%
|
| 5 | KANTO CHEMICAL CO.,INC. |
11.4%
|
| 6 | MilliporeSigma |
9.1%
|
| 7 | East India Chemicals |
6.8%
|
| 8 | Hefei Home Sunshine Pharmaceutical Technology Co., Ltd. |
6.8%
|
| 9 | Alpha Chemika |
4.5%
|
| 10 | Foodchem International Corporation |
4.5%
|
Derivation Method
The ranking is calculated based on the click share within the inosine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
3 | 42.9% |
|
China
|
2 | 28.6% |
|
United States of America
|
1 | 14.3% |
|
Japan
|
1 | 14.3% |
