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This section provides an overview for chelating agents as well as their applications and principles. Also, please take a look at the list of 10 chelating agent manufacturers and their company rankings. Here are the top-ranked chelating agent companies as of December, 2024: 1.SAE Manufacturing Specialties Corp, 2.Hexion., 3.Dow Corporate.
Table of Contents
Chelating Agents are agents that form complexes with metal ions, which cause various adverse effects, to reduce their activity.
There are various types of chelating agents, but basically they are based on an amino carboxylic acid structure, such as EDTA and DTPA, which are representative.
Amino carboxylic acid structure: refers to a structure with both an amino group (-NH2) and a carboxyl group (-COOH) in the molecule.
Chelating agents are used to balance solutions and adjust ion concentrations due to their high water solubility and stabilizing effects. Chelating agents that bind and react only with specific metals can also be used to recover valuable metals and sort and dispose of hazardous metals.
Iron overload is a disease in which excess iron accumulates in the body for some reason, causing various symptoms such as fatigue and pain in body joints. Iron works well in moderate amounts, but its presence in excess has adverse effects.
Iron chelating agents are available to remedy this. The main ingredients are organic molecules such as deferoxamine and deferasirox. They form chelate complexes with iron and expel it from the body. In this way, metal components and radioactive substances that are present in excess in the body can be discharged and properly controlled.
Chelating agents are mainly added to dishwashing detergents and laundry detergents to protect the surfactants that control their cleaning performance from metal ions.
In the case of EDTA, the most typical chelating agent, the compound formed by the reaction of metal ions and the chelating agent is called a chelating complex, which remains soluble in the liquid without precipitation.
The complex is formed in a three-dimensional structure reminiscent of crab scissors, and the metal is trapped inside the complex, thereby exerting a metal sealing effect. The metal-blocking action refers to the ability to prevent other ions from binding to calcium ions and iron ions contained in water.
For example, laundry detergents contain chelating agents, which are intended to prevent negatively charged surfactants from binding with calcium and iron ions in tap water. Since surfactants are cleaning ingredients, their cleaning ability is significantly reduced when they bind with metal ions in the water. Therefore, to prevent metal ions from reactively binding with surfactants, Chelating agents with metal sequestering properties are added.
A wide variety of chelating agents such as EDTA, DTPA, and HEDTA can be selected according to the application. Since the type and performance of metal ions that coordinate and bind differ depending on the type, care and confirmation are required when selecting a chelating agent.
There are many types of chelating agents used in foods, depending on the purpose and application. The four most common chelating agents are ethylenediaminetetraacetic acid, citric acid, phytic acid, and gluconic acid.
Two types of EDTA are designated as antioxidants: disodium EDTA and disodium calcium EDTA. They work to trap metal ions that promote oxidation. Some restrictions are placed on its use, and it can only be used in canned and bottled foods. Depending on the criteria for use, disodium EDTA must be inactivated by calcium disodium EDTA prior to completion of the final food product.
Used as an acidifier to enhance the flavor of foods. It is well known as the main ingredient in citrus fruits such as lemons and oranges. It forms chelate complexes with minerals that enter the body, making them easier to absorb.
Gluconic acid is used as a substitute for miso and salt. It is also widely used as an odor masking agent, pH adjuster, and discoloration inhibitor. It is added with ingredients such as sodium gluconate and glucono delta-lactone.
Utilized as an anti-discoloration agent, antioxidant, etc., this substance is abundant in rice bran and nuts. It forms and retains chelate complexes with minerals such as calcium, iron, copper, and zinc. There is concern that high content of this substance may inhibit the absorption of essential minerals because its chelating action becomes too strong.
The chelation value (CV) is an indicator of the amount of metal ions with which a chelating agent can form complexes. This is defined by the number of mg of calcium carbonate that 1 g of chelating agent can form a coordination bond with, and the unit is mgCaCO3/g. In the case of EDTA-4H, the unit is mgCaCO3/g.
In the case of EDTA-4H, the CV is 342 mgCaCO3/g, and this value can be calculated as follows: EDTA and calcium ions bind 1:1, so 1 mol of calcium carbonate is required to saturate 1 mol of EDTA-4H with calcium ions.
Thus, if the molecular weight of calcium carbonate is 100 and that of EDTA-4H is 292, 1 g of EDTA-4H is needed to bind 342 mg of calcium carbonate.
Thus, if we know how much metal a chelating agent can sequester, we can calculate the approximate amount to be added when actually using the chelating agent.
*Including some distributors, etc.
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Hexion came into being in 1899 and is headquartered in Columbus, Ohio, USA, as a manufacturer of adhesives and performance materials. The company's product portfolio consists of VeoVaTM vinyl esters, VersaticTM Acid 10, Formaldehyde 50% Solution, and CarduraTM E10P glycidyl ester. The products play a crucial role in various applications, such as improving adhesion and cohesiveness in waterborne pressure-sensitive adhesives, enhancing rubber adhesion in tire manufacturing, and facilitating the production of low-VOC acrylic polyol resins. The company serves various industries, including tire manufacturing, thermoset resin production, organic chemicals, and agricultural chemicals.
Based in Bayville, NY, SAE Manufacturing Specialties Corp. is an ISO-certified supplier and manufacturer of industrial equipment, chemicals, components, ordinance, electronics, and systems for industries ranging from aerospace to high tech to law enforcement. Examples of product offerings include raw materials, chemicals, and lubricants for industrial purposes to finished products such as security helmets for law enforcement, and military ordnances. SAE also provides research and development as well as technical support for other companies in similar industries.
Dow Inc. was originally incorporated in 1897 and is headquartered in Midland, Michigan. The company is a manufacturer and distributor of numerous advanced materials and chemicals used in packaging, infrastructure, and consumer industries by other companies around the world. The company’s product divisions include Packaging & Specialty Plastics, Industrial Intermediates & Infrastructure, and Performance Materials & Coatings. Packaging & Specialty Plastics include ethylene, rubbers, and wire and cable products. Industrial Intermediates & Infrastructure include ethanol amines, adhesives, sealants, and other composites. Performance Materials and Coatings provides paints and industrial coatings for metal packing.
Lotioncrafter was established in 2002 and is headquartered in Eastsound, Washington, USA, as a manufacturer and supplier of natural materials for the development of cosmetics and toiletries. The company's product portfolio consists of Abyssinian Oil, ActifcolTM, Adifyline, Allantoin USP, and Aloe Vera 100X Powder, among others. The products find applications in skincare formulations for various purposes, including anti-aging, volume enhancement, and addressing specific concerns related to mature skin on the face, neck, and décolleté area. The company serves various industries, including cosmetics, skincare, pharmaceuticals, healthcare, and dermatology.
Mitsubishi Chemical Corporation was founded in 1933 and has a head office in Tokyo, Japan. Mitsubishi Chemical Corporation provides products including chemicals, industrial gases, and health care products to customers globally. Mitsubishi Chemical Group’s performance products division manufactures and distributes. functional food materials, electronic and electrical components, specialty chemicals, and other products. Mitsubishi Chemical health care products include pharmaceuticals, drug discovery solutions, diagnostic reagents, and instruments for medical use. Mitsubishi Chemical Corporation also provides other services such as engineering, information systems, logistics, and consulting.
Nouryon has a history dating back to 1646 Sweden but was officially formed in 2018 after gaining independence from AkzoNobel. The company is a manufacturer of everyday consumer products including personal care and cleaning goods, as well as products for the agricultural, pharmaceutical, and building industries. The company’s brands include Dissolvine, Witbreak, Butanox, and Ferrazone. These brands manufacture products across five product segments: Bleaching and Oxidizing Chemicals and Technologies, Specialty Polymers, Surfactants and Chelating Agents, Polymer Production and Processing Chemicals, and Specialty Chemicals and Intermediates.
Nippon Shokubai Co. LTD., established in 1941 and headquartered in Osaka, Japan, is a chemical manufacturer providing diverse chemical materials. Some of its products include detergents, curing agents, heat-resistant resins, adhesives, and coatings for metal, and the products are used in various industries, including life science, ICT, consumer products, environment remediation, and energy. In 1941, the company started the first commercial production of Phthalic Anhydride, which led to the development of the vinyl chloride industry. It commercialized Ethylene Oxide in 1959 using domestic technologies and began mass-producing superabsorbent polymers in 1985.
Delamine B.V. was established in 1908 and is headquartered in Amersfoort The Netherlands, and manufactures and supplies in shipbuilding, road construction, the automotive industry, customer products, paint, healthcare, and even toilet paper, tea bags, or diapers powered by delamines. The portfolio of the company consists of EDA, N-AEP - N, DETA, TEPA, TETA, and many more. The company operates as an EDC-based manufacturer. From the company’s headquarters and own production plant in the Netherlands, the company exports ethylene amines to well over 50 countries globally. And it interacts with more than 15 different strategic markets.
CD Bioparticles, founded in Shirley, New York, is a manufacturer of biocompatible drug delivery systems. The company's product portfolio includes Liposomes, PEGylated liposomes, Polymer microspheres, Nanoparticles and Functional Biomedical Coatings. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. They also provide Contract services of drug delivery formulation developments, Product Selection Guidance, customer support, custom research projects and customized services.
S&P Global Inc., established in New York, NY, in 1860, is a provider of credit ratings, benchmarks, analytics and workflow solutions in the global capital, commodity and automotive markets. Their products and services include market insight and analytics, real time news, geospatial data, and risk valuation data. The company serves markets such as shipping, petrochemicals, metals, agriculture, and energy transition. The company provides services in over 150 countries and their customers include government agencies, financial institutions, and professional service firms in law.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | SAE Manufacturing Specialties Corp |
25.1%
|
| 2 | Hexion. |
12.3%
|
| 3 | Dow Corporate |
11.3%
|
| 4 | Mitsubishi Chemical Corporation |
10.8%
|
| 5 | Nouryon |
9.4%
|
| 6 | Lotioncrafter |
8.9%
|
| 7 | Delamine B.V. |
6.4%
|
| 8 | NIPPON SHOKUBAI CO., LTD. |
5.9%
|
| 9 | S&P Global Inc. |
4.9%
|
| 10 | CD Bioparticles |
4.9%
|
Derivation Method
The ranking is calculated based on the click share within the chelating agent page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 66.7% |
|
Japan
|
1 | 16.7% |
|
Netherlands
|
1 | 16.7% |
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