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This section provides an overview for dimethyl sulfate as well as their applications and principles. Also, please take a look at the list of 13 dimethyl sulfate manufacturers and their company rankings. Here are the top-ranked dimethyl sulfate companies as of December, 2024: 1.Labdhi Chemicals, 2.GRILLO, 3.BASF.
Table of Contents
Dimethyl Sulfate is the dimethyl ester of sulfuric acid.
Other names include Dimethyl Sulfate, Methyl Sulfate, Dimethyl Sulfate Ester, and DMS. Dimethyl Sulfate is strictly a conventional name.
It is classified as a priority chemical substance under the Law Concerning the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law). It is also regulated under the Industrial Safety and Health Law, Poisonous and Deleterious Substances Control Law, and Fire Service Law, in addition to being a regulated item under the Water Pollution Control Law's Accidental Measures (Designated Substances).
Dimethyl Sulfate is widely used as a strong alkylating agent. As a result, it is often used as a pharmaceutical or synthetic raw material. Specifically, it is often used to methylate the hydroxy group (-OH) of phenols and alcohols, the amino group (-NH2) of amines, and the thiol group (-SH) of thiols.
It is also a well-known alkylating agent used in the chemical methylation of nucleic acids. Historically, it was used for DNA sequencing by the Maxam-Gilbert sequencing method.
Dimethyl Sulfate has a melting point of -32°C and decomposes at 188°C. It is a colorless oily liquid with a weak onion-like odor. It is soluble in ethanol, acetone, dichloromethane, and various ethers. It is insoluble in water and is gradually hydrolyzed.
Dimethyl Sulfate is not irritating, but is extremely toxic to the human body. If the vapor is inhaled or left on the skin, it can be absorbed into the body and cause poisoning. Kidneys, liver, and heart may be affected, and death may result from necrosis of the skin and inflammation of the respiratory mucous membranes, so care must be taken when handling it.
Dimethyl Sulfate is a neutral ester with the chemical formula (CH3)2SO4 or (CH3O)2SO2. It is also denoted as Me2SO4. Its molar mass is 126.13 g/mol and density is 1.33 g/ml.
Reaction of fuming sulfuric acid with dry methanol or dimethyl ether yields methyl hydrogen sulfate. Methyl hydrogen sulfate can be distilled and converted to Dimethyl Sulfate.
Methyl hydrogen sulfate can also be synthesized by reacting methyl chlorosulfonate with methyl nitrite.
In industrial use, it is synthesized by the sequential reaction of dimethyl ether with sulfur trioxide (SO3).
Dimethyl Sulfate is generally used in the methylation of phenols and is also suitable for the methylation of alcohols. For example, tert-butyl methyl ether can be synthesized from tert-butanol. In the case of alkoxides, methylation is immediate. As with alcohols, methylation of thiols also occurs readily. Thioesters can be produced from thiocarboxylic acids.
Methylation of amines allows the synthesis of tertiary amines and quaternary ammonium salts. Quaternary ammonium compounds with long-chain alkyl groups can be used in clothing softeners and surfactants.
Dimethyl Sulfate can also cleave DNA base-specifically through the ring-opening reaction of the imidazole ring of guanine, which is useful in DNA strand breaks and sequencing. When reacted with copper(I) oxide, copper(I) sulfate is obtained.
Cancer has been observed in rats after inhalation or intravenous administration. Because it is toxic and difficult to handle, it tends to be substituted for other methylating agents in the laboratory.
Methyl iodide is used for O-methylation and is expensive but less hazardous. Dimethyl carbonate is less toxic than methyl iodide and dimethyl sulfate and can be used in place of dimethyl sulfate for N-methylation. However, Dimethyl Sulfate may be judged an appropriate reagent because of its higher reaction efficiency and easier availability.
*Including some distributors, etc.
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Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
A.B. Enterprises was established in 1984 and is headquartered in Maharashtra, India. The company is a manufacturer and supplier of general chemicals, specialties, and industrial chemicals to a broad range of industries including food, textile, plastic, rubber, and other industries. The company exports primarily to Canada, Bahrain, and Dubai. The company’s five major product segments include petrochemicals, food chemicals, laboratory chemicals, water treatment chemicals, and fine chemicals. In addition, the company manufactures dentistry materials, pesticides, and chemical supplies.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Industrial Solvents & Chemicals Pvt. Ltd. was founded in 1959 in Mumbai, India, as a manufacturer of hazardous chemicals based on methanol, ethanol, and aniline. The company's product line encompasses Dimethyl Sulphate (DMS), Oleum 65%, Liquid Sulphur Trioxide, Sulphuric Acid 70%, and Ether Anaesthetic IP, among others. The products serve as reagents in chemical synthesis processes and are vital for industrial operations and battery production. Finding application in various chemical processes, the products are also utilized in chemical synthesis, dye and pigment production, and anesthesia. The company serves various industries, including construction, manufacturing, medical, electrical, chemical, and pharmaceuticals.
Aarti Industries Limited (AIL) is a global manufacturer of speciality chemicals and pharmaceuticals based in India. They were founded in 1984 and provide services to the chemical industry's 700+ domestic clients as well as 400+ international clients. Chemical products produced by Aarti Industries are used in the production of pharmaceuticals, agrochemicals, polymers, additives, and dyes. They started out as an Indian company serving international markets and now they are a worldwide organization with manufacturing facilities in India.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
BASF Corporation, established in 1986 as the North American affiliate of BASF SE, is a manufacturer of chemical products, headquarters in Florham Park, New Jersey. The company operates 11 divisions which specialize in six business segments, namely chemicals, materials (such as plastics and rubber), industrial solutions, surface technologies (including construction chemicals and coating solutions), nutrition (for human and animal), and agricultural solutions. BASF's products find extensive applications across diverse industries such as automotive and transportation, construction, consumer electronics, energy, and furniture. Additionally, the company serves the medical and pharmaceuticals, paints and coatings, power tools, pulp and paper, as well as textile industries.
Labdhi Chemicals was established in 2007 in Maharashtra, India, as a manufacturer and supplier of chemicals. The company offers organic chemicals, inorganic chemicals, agrochemicals, specialty chemicals, and pharmaceutical chemicals, among others. These products serve as crucial components in the formulation of medications and find utility in pharmaceutical formulation, cosmetic creation, and plastics production. They play a pivotal role in manufacturing processes and construction materials, improve agricultural practices through fertilizers, pesticides, and herbicides, and offer specialized functionalities in industries such as textiles and adhesives. The products meet the requirements of many industrial sectors, such as pharmaceutical companies, cosmetic industries, and agricultural sectors.
GRILLO was established in 1842 and is headquartered in Duisburg, Nordrhein-Westfalen, Germany, as a manufacturer of products and solutions based on zinc and sulfur. The company offers various products, including sulfuric acid, sulfur dioxide, oleum, zinc sulfate, and sodium bisulfate, among others. The products find application in battery manufacturing, biodiesel catalysts, acne treatment, medical device sterilization, fertilizer and pharmaceutical production, and as catalysts in fiber and textile manufacturing. The company caters to various industries, including automotive, cosmetics and healthcare, agriculture, chemicals, energy, plastic, rubber, and glass.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Labdhi Chemicals |
13.1%
|
| 2 | GRILLO |
12.1%
|
| 3 | BASF |
11.2%
|
| 4 | A. B. Enterprises |
10.3%
|
| 5 | LobaChemie Pct.Ltd. |
9.3%
|
| 6 | Industrial Solvents & Chemicals Pvt. Ltd. |
8.4%
|
| 7 | Merck |
8.4%
|
| 8 | Kishida Chemical Co.,Ltd. |
7.5%
|
| 9 | FUJIFILM Wako Pure Chemical Corporation |
7.5%
|
| 10 | Aarti Industries Limited |
4.7%
|
Derivation Method
The ranking is calculated based on the click share within the dimethyl sulfate page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 55.6% |
|
Japan
|
3 | 33.3% |
China
|
1 | 11.1% |
