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This section provides an overview for dichloromethane as well as their applications and principles. Also, please take a look at the list of 15 dichloromethane manufacturers and their company rankings. Here are the top-ranked dichloromethane companies as of December, 2024: 1.Tedia Company Inc., 2.SRL, 3.Greenfield Global Inc..
Table of Contents
Dichloromethane (DCM), also known as methylene chloride or methylene dichloride, is a colorless liquid noted for its strong, sweet aroma. It may cause mild irritation or chemical injury upon skin contact. Due to its anesthetic vapor, inhaling large quantities quickly can lead to acute poisoning, necessitating caution during use. DCM is produced by chlorinating methyl chloride or by reducing chloroform with zinc and acetic acid.
Dichloromethane finds broad industrial applications as a refrigerant, cleaning agent for metal equipment and printed circuit boards, foaming aid for urethane, paint stripper, and aerosol propellant. It is a preferred solvent for organic substances due to its low boiling point and high purity requirements. Additionally, dichloromethane is used in manufacturing polycarbonates, pharmaceuticals, agrochemicals, and precision analysis like liquid chromatography.
It is favored over other halogenated hydrocarbons due to its nonflammability, lower toxicity, and as an alternative to trichloroethylene.
With a chemical formula of CH2Cl2, DCM's structure consists of two chlorine atoms replacing two hydrogen atoms in methane. It has a density of 1.3266 g/cm³, a melting point of -96.7°C, and a boiling point of 40°C. Dichloromethane is notable for its heavier density compared to water, aromatic odor, and excellent solubility in ethanol and diethyl ether, though it is somewhat insoluble in water. It dissolves a vast array of organic compounds.
Dichloromethane is industrially produced through a radical reaction between methane or methyl chloride and chlorine gas at 400-500°C. This process yields a mixture including chloromethane, dichloromethane, trichloromethane (chloroform), and tetrachloromethane (carbon tetrachloride), from which DCM can be purified by distillation.
For organic synthesis, dehydration with a molecular sieve generally suffices. For precision work, distillation with calcium hydride as a drying agent is recommended, avoiding sodium to prevent explosive reactions.
Though stable, highly purified dichloromethane can decompose oxidatively when exposed to oxygen or light, producing harmful byproducts like hydrogen chloride or phosgene. To minimize this risk, stabilizers such as alcohols, olefins, and amines are added, and the substance should be stored in tightly sealed, light-protected containers.
*Including some distributors, etc.
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Tedia is a manufacturer of solvents based in Ohio where it was established in 1975. The company is involved in the processing and purifying of solvents and they also provide services for packaging these solvents in metal, glass, specialty plastics, and more along with delivery in specially designed recylcetainers to laboratories and manufacturing facilities. These products have applications for biological testing, and manufacturing along with oligonucleotide synthesis by providing chemically and optically purified Oligo Synthesis Grade Acetonitrile. The cannabis and hemp market acquires solvents for the extraction process, oil refining, material processing, and QC testing.
American Elements was founded in 1997 in California and currently has research and production facilities in Utah, Mexico, China, and the United Kingdom. AE manufactures and distributes advanced materials from a catalog of over 30,000 products for bulk industrial use as well as small scale laboratory use. AE also provides testing and analyses services including spectroscopy along with structural, thermal, and electrical analyses. AE holds sustainable development as a core corporate value and is committed to work to protect the health of the environment.
Sankyo Chemical Co. LTD., established in 1957 and headquartered in Nagoya, Japan, is a manufacturer of several intermediate materials, including paints, industrial cleaning agents, thinners, organic industrial chemicals, and adhesives. The products can be used in several areas, including silk screen printing, wiping off resin, washing agents for flux, metal processing, and mold forming. The company accepts contract manufacturing and provides several environmentally friendly products that comply with ISO 14001, the Industrial Safety and Health Law, and the PRTR (Pollutant Release and Transfer Register) Law.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
INTERLAB Laboratory Products is a laboratory equipment and consumables manufacturer, established in 1983 and headquartered in Turkey. The company serves pharmaceuticals, biotechnology, research, and healthcare industries, among others. Its portfolio of products includes glassware, plasticware, lab equipment, and consumables, used for research, diagnostics, and quality control. The company's products support accurate experimentation and testing in diverse fields, advancing scientific and medical research while also counting with a team of high-specialized professionals to support its customers.
Dräger, established in 1889, and headquartered in Lübeck, Germany, is a manufacturer and supplier of advanced safety and medical technology products. They offer a range of solutions, including gas detection systems, respiratory protection equipment, patient monitoring systems, ventilators, and anesthesia machines, which are designed for industries such as oil and gas, chemical, firefighting, healthcare, and mining. Dräger is certified with ISO 9001 for quality management and ISO 13485 for medical devices.
Honeywell, founded in 1906, in Wabash, Indiana is manufacturer of automotive parts, building technologies, and performance and safety materials for aerospace, The company's product portfolio includes electronic guidance systems, cockpit instrumentation, lighting, automotive parts, and primary propulsion and secondary power turbine engines. The company serves industries such as Oil and Gas, Aerospace and Defense, Automotive and Transportation, Construction, and Power Generation. Their headquartere is located in Carolina and they have global sales offices and distributions channels.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Greenfield Ethanol Inc., established in 1989 in Canada, is a supplier of high-purity alcohols, specialty solvents, custom blended solutions, and fuel ethanol to businesses worldwide. The company’s primary markets include renewable fuels, beverage alcohols, life science, food, flavor, fragrance, personal care, and industrials. It has an extensive global supply chain that includes five alcohol distilleries, five blending and packaging facilities, and eight warehouses. It operates one of the largest anaerobic digestion facilities in North America, converting more than 120,000 MT of source-separated organics every year to produce renewable natural gas. Its low-carbon ethanol helps industries decarbonize and meet net-zero targets.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Tedia Company Inc. |
18.5%
|
| 2 | SRL |
11.3%
|
| 3 | Greenfield Global Inc. |
9.5%
|
| 4 | Tokyo Chemical Industry Co., Ltd. |
9.5%
|
| 5 | American Elements |
8.9%
|
| 6 | Dräger |
7.7%
|
| 7 | Honeywell |
6.5%
|
| 8 | Merck |
4.8%
|
| 9 | INTERLAB Laboratory Products |
4.2%
|
| 10 | Junsei Chemical Co.,Ltd. |
4.2%
|
Derivation Method
The ranking is calculated based on the click share within the dichloromethane page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
6 | 54.5% |
|
United States of America
|
2 | 18.2% |
|
India
|
2 | 18.2% |
|
Canada
|
1 | 9.1% |
ChemFine International Co., Ltd.
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