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This section provides an overview for guanidine hydrochloride as well as their applications and principles. Also, please take a look at the list of 17 guanidine hydrochloride manufacturers and their company rankings. Here are the top-ranked guanidine hydrochloride companies as of December, 2024: 1.MUBY CHEMICALS, 2.R P Chemicals, 3.BioSpectra, Inc..
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Guanidine hydrochloride is the hydrochloride salt of guanidine, with the chemical formula CH6ClN3. It is a white, crystalline powder with high solubility in water and is used as a protein solubilizer, an antistatic agent for synthetic fibers, and a reagent in pharmaceutical synthesis. It is produced from dicyandiamide and ammonium hydrochloride.
Guanidine hydrochloride serves as a protein solubilizer (protein denaturant), acting as a chaotropic agent that destabilizes protein molecular structures by disrupting their hydrogen bonds. This property is leveraged in biochemistry for DNA purification and RNA extraction, as it can inactivate ribonuclease, an enzyme that degrades ribonucleic acid.
As a component in antistatic agents for synthetic fibers such as polyester and nylon, guanidine hydrochloride works in conjunction with surfactants and cationic polymers to uniformly protect the fiber surface without impairing performance.
In pharmaceutical synthesis, guanidine hydrochloride is utilized as a precursor for folic acid, essential for red blood cell production, and as a base material for synthesizing sulfa drugs, which serve as antibacterial agents.
Historically, guanidine hydrochloride was employed in oral medications to alleviate muscle weakness in patients with Lambert-Eaton syndrome. However, its use has declined due to side effects like gastrointestinal disturbances.
| Chemical Formula | CH6ClN3 |
| Common Names | Guanidine Hydrochloride, Guanidinium Chloride |
| CAS Number | 50-01-1 |
| Molecular Weight | 95.53 g/mol |
| Melting Point | 182°C |
Guanidine hydrochloride, also referred to as guanidine chloride or guanidinium hydrochloride, is commonly abbreviated as GdmCl, GndCl, or GuHCl.
Highly soluble in water and alcohols, guanidine hydrochloride must be handled with care due to its hygroscopic nature, readily absorbing moisture from the air.
Although not regulated under specific industrial or labor laws, guanidine hydrochloride is classified in the GHS as acutely toxic, and a skin and eye irritant/corrosive.
To mitigate its irritating effects on skin and eyes, the use of protective gloves, glasses, and clothing is advised. In case of contact, immediate rinsing with water and seeking medical attention is recommended. Workplace safety measures include the installation of wash basins, safety showers, and appropriate ventilation equipment.
Stable at room temperature, guanidine hydrochloride should be stored in a sealed container in a dry environment to prevent moisture absorption.
Transport requires adherence to safety regulations, including carrying a yellow card and avoiding co-transportation with food or feed. Disposal must follow local environmental regulations to prevent environmental release.
*Including some distributors, etc.
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BioSpectra, Inc., established in 1993 and headquartered in Bangor, Pennsylvania, is a manufacturer and supplier of high-purity biochemicals and enzymes. The company offers a diverse range of products, including pharmaceutical-grade sugars, buffers, amino acids, nucleotides, and enzymes. These products serve as essential components in pharmaceutical, biotech, and research applications, supporting the development and production of medicines, diagnostics, and other biologically active substances. Its onsite analytical testing capabilities include multi-compendial and custom specifications with full traceability and transparency of all raw materials and sources, operating from its FDA registered & inspected GMP manufacturing space under the most rigorous quality system.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Jinan Qinmu Fine Chemical Co., Ltd., established in 2008, is a Chinese manufacturer of chemical products, headquartered in Jinan, Shandong. The company offers organic and inorganic chemicals, including solvent chemicals, catalysts, and auxiliaries. Additionally, the company provides dye and pigment chemicals, pharmaceutical and synthetic intermediates, active pharmaceutical ingredients (APIs), and biochemical products. Customized intermediates are also available to meet the specific needs of original equipment manufacturers (OEMs). As an ISO 9001 and ISO 14001 certified company, Qinmu Fine Chemical Co., Ltd. serves a global customer base, including clients like Miwon Specialty Chemical Co., Ltd., Synthos S. A., and Gujarat Fluorochemicals Limited (GFL).
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd. (HHSPT) is a Chinese ISO 9001 certified manufacturer of intermediates, active pharmaceutical ingredients (APIs), and fine chemicals founded in 2013 and based in Hefei City. The company offers over 5,000 different products including coenzyme and nucleotide series chemicals, as well as APIs for the treatment of conditions such as diabetes and chronic liver disease. It also provides reagents and chemicals used for research and analysis applications. HHSPT products are primarily used by drug manufacturers, as well as by clients in laboratory R&D and the biotechnology industry.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
R P Chemicals, founded in India in 2020 is a manufacturer of fine chemical compounds and laboratory chemicals. The company offers chemical products that are used in pharmaceutical industries, FMCG production units, and many food industries. It also produces chemicals like vitamin C powder, white silica gel, salicylic acid, liquid Isopropyl alcohol, and Meta nitro benzoic acid that are used by cosmetic and healthcare wellness sectors. It exports its products worldwide and follows quality control procedures to meet industry standards.
Shizuishan Pengsheng Chemical Co., Ltd, established in 2003, based in Shizuishan City, Ningxia, China, is a manufacturer of dicyandiamide, calcium, and cyanamide products. The company product portfolio includes calcium carbide, calcium cyanamide, dicyandiamide, guanidine carbonate, and guanidine hydrochloride. In 2013, it was selected as one of "the third batch of pilot enterprises of the circular economy in Ningxia Hui Autonomous Region". It employs over 500 employees. The company serves customers domestically and internationally.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
SUVCHEM, established in 2004 and headquartered in Mumbai, India, is a manufacturer and exporter of laboratory chemicals and reagents. Their diverse product range includes organic and inorganic chemicals utilized in pharmaceuticals, plastics, water treatment, and more. They also offer biological stains and indicators for laboratory applications like cell culture and DNA analysis, along with culture media ingredients for growing microorganisms. SUVCHEM's products cater to schools, colleges, research laboratories, pharmaceutical and chemical companies, and other industries, supporting teaching, research, product development, and manufacturing processes across various sectors.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ataman Kimya, established in 2006, is a distributor of chemicals based in Istanbul, Turkey. Their wide range of products includes detergents, cosmetics, disinfectants, pharmaceutical chemicals, and water treatment chemicals. They also offer textile, leather, paper, and mining chemicals. These chemicals, such as hydrogenated castor oils, ethanol, and butylene glycol, find applications in various industries, such as personal care, household cleaning, fragrance, coatings, and agriculture. The company also offers custom blending to meet specific requirements.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MUBY CHEMICALS |
23.5%
|
| 2 | R P Chemicals |
8.8%
|
| 3 | BioSpectra, Inc. |
8.8%
|
| 4 | Kishida Chemical Co.,Ltd. |
8.8%
|
| 5 | KANTO CHEMICAL CO.,INC. |
8.8%
|
| 6 | Hefei Home Sunshine Pharmaceutical Technology Co., Ltd |
5.9%
|
| 7 | Fengchen Group Co.,Ltd |
5.9%
|
| 8 | MilliporeSigma |
5.9%
|
| 9 | Qinhuangdao Tianzi chemical Industry Co., Ltd. |
2.9%
|
| 10 | Shizuishan Pengsheng Chemical Co., Ltd |
2.9%
|
Derivation Method
The ranking is calculated based on the click share within the guanidine hydrochloride page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 30.8% |
|
China
|
4 | 30.8% |
|
India
|
4 | 30.8% |
|
United States of America
|
1 | 7.7% |
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