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This section provides an overview for guanidine as well as their applications and principles. Also, please take a look at the list of 9 guanidine manufacturers and their company rankings. Here are the top-ranked guanidine companies as of December, 2024: 1.BioSpectra, Inc., 2.Tokyo Chemical Industry Co., Ltd., 3.KANTO CHEMICAL CO.,INC..
Table of Contents
Guanidine is an organic compound with the molecular formula CH5N3. It is also known as imido carbonic acid diamide, and its CAS number is 113-00-8.
It has a molecular weight of 59.07, a melting point of 50°C, a boiling point of 160°C (decomposition), and exists as a colorless crystalline powder at room temperature. It is strongly basic, with an acid dissociation constant pKa of 12.5. It is readily soluble in water and also soluble in ethanol, methanol, and dimethylformamide.
It is a chemical found in nature in mushrooms and earthworms, and is also detected in human urine because it is produced by protein metabolism.
In air, it absorbs carbon dioxide, which changes its properties, so it must be stored in a tightly sealed container.
Guanidine is used as a raw material for plastics and explosives.
In addition, due to its ability to easily form hydrogen bonds, salts of guanidine are used in a variety of fields. For example, the hydrochloride salt (guanidinium chloride) and the thiocyanate salt (guanidine thiocyanate) are often used as protein denaturants in the biochemical field.
Synthetically, guanidine nitrate is used as an ingredient in gunpowder, and guanidine hydrochloride is used as a synthetic ingredient in pharmaceuticals and dyes.
Guanidine phosphate is used as an excellent fire retardant for paper and wood. In addition to being highly flame retardant, guanidine phosphate is believed to prevent moisture absorption and iron corrosion.
In recent years, research has been conducted to use guanidine as an alternative to fossil fuels. Guanidine and the guanidino group are strong bases, and there are many derivatives of guanidine that are used as strong bases in organic synthesis.
Other applications include raw materials for synthesizing photographic materials, disinfectants, and many other fields.
Guanidine is stabilized by delocalization of the positive charge of the conjugated acid on the three nitrogens due to resonance, and exhibits strong basicity. Thus, under physiological conditions, it exists as a protonated +1-valent cation (guanidinium ion).
When heated to 160°C, it releases ammonia and converts to melamine (C3H6N6).
A compound containing guanidino groups is arginine, a type of amino acid. Arginine is a substance known to play an important role in proteins, such as binding to DNA.
Among natural product alkaloids, compounds containing guanidino groups biosynthesized from arginine are known, and many of them have strong physiological effects, such as saxitoxin and tetrodotoxin.
In addition, nitroguanidine, in which a nitro group is substituted for guanidine, is a substance known as a raw material for explosives.
Guanidine pure substances are sold primarily as reagent products for research and development; they are sold in volumes of 5 g, 10 g, etc., and are compounds that are sometimes stored under refrigeration due to their tidal properties.
Guanidine is more commonly sold as a salt than as guanidine itself. It is available as a reagent product for research and development and as an industrial chemical.
Available reagent products for research and development include guanidine hydrochloride, guanidine nitrate, guanidine thiocyanate, guanidine phosphate, guanidine carbonate, guanidine sulfamate, and guanidine hydrobromide.
Compounds with biochemical applications, such as hydrochloride and thiocyanate, are often available in grades such as molecular biology/biochemistry, so it is necessary to select the product grade that best suits your application. Types of capacities commonly exist, such as 25g, 100g, 500g, etc.
Similarly, guanidine hydrochloride, guanidine nitrate, guanidine phosphate, guanidine carbonate, guanidine sulfamate, and others are available as industrial chemicals.
Products such as 60% aqueous hydrochloride solutions may also be available. These products are used as raw materials for organic synthesis, raw materials for fiber treatment agents, raw materials for bioprocessing, and raw materials for clinical laboratories.
*Including some distributors, etc.
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BioSpectra, Inc., established in 1993 and headquartered in Bangor, Pennsylvania, is a manufacturer and supplier of high-purity biochemicals and enzymes. The company offers a diverse range of products, including pharmaceutical-grade sugars, buffers, amino acids, nucleotides, and enzymes. These products serve as essential components in pharmaceutical, biotech, and research applications, supporting the development and production of medicines, diagnostics, and other biologically active substances. Its onsite analytical testing capabilities include multi-compendial and custom specifications with full traceability and transparency of all raw materials and sources, operating from its FDA registered & inspected GMP manufacturing space under the most rigorous quality system.
MCLAB, founded in 1983, is a supplier and distributor of molecular biology and genomics products based in California, USA. The company provides various products and services to support molecular biology research and genetic analysis. Its products include DNA and RNA extraction kits, PCR reagents, DNA sequencing services, and various tools for cloning. With services such as DNA sequencing, the company allows researchers to analyze and decipher the genetic information of DNA samples, offering Sanger sequencing and next-generation sequencing (NGS) services, which are essential for genomics research. The company has maintained ISO9001:2015 certification, demonstrating its quality and consistent product standards.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
IBI Scientific was founded in 2004 and is based in Dubuque, Iowa, USA, as a manufacturer of life science research instruments and reagents. The company's product line includes the Belly Button Orbital Shaker, Hi-Lo Rocker, Ammonium Persulfate, Ampicillin Sodium Salt, and Angled BETA-GARD Shield, among others. These instruments find usage in biofilm development, electrophoresis, suppression of cell wall production, inhibition of bacteria in cell culture, and western blot treatments. The company caters to various industries including laboratory, chemical, and research.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | BioSpectra, Inc. |
26.3%
|
| 2 | Tokyo Chemical Industry Co., Ltd. |
15.8%
|
| 3 | KANTO CHEMICAL CO.,INC. |
15.8%
|
| 4 | MCLAB |
10.5%
|
| 5 | IBI Scientific |
10.5%
|
| 6 | MilliporeSigma |
10.5%
|
| 7 | Glentham Life Sciences Limited |
5.3%
|
| 8 | Merck |
5.3%
|
Derivation Method
The ranking is calculated based on the click share within the guanidine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
3 | 50.0% |
|
United States of America
|
2 | 33.3% |
|
United Kingdom
|
1 | 16.7% |
