All Categories
History
This section provides an overview for acetyl chloride as well as their applications and principles. Also, please take a look at the list of 15 acetyl chloride manufacturers and their company rankings. Here are the top-ranked acetyl chloride companies as of December, 2024: 1.Remedy Labs, 2.BHAGWATI CHEMICALS, 3.A. B. Enterprises.
Table of Contents
Figure 1. Basic Information on Acetyl Chloride
Acetyl chloride, derived from acetic acid, is known chemically as ethanoyl chloride. It produces white smoke in moist air due to its reaction with water, resulting in acetic acid and hydrogen chloride. This reactivity means it is seldom found naturally.
Available commercially, acetyl chloride can be synthesized through reactions involving acetic acid with thionyl chloride or phosphorus trichloride.
Acetyl chloride is pivotal in organic synthesis, particularly for introducing the acetyl group (CH3CO-) into organic compounds. Its application in the Friedel-Crafts reaction, alongside a Lewis acid catalyst like AlCl3, aids in synthesizing aromatic ketones. It is also used to produce acetophenone and ethyl acetate via acetylation of benzene and ethanol, respectively.
As a colorless, flammable liquid at room temperature, acetyl chloride has a pungent odor and can irritate the eyes and skin. It exhibits a density of 1.105 g/cm3, with melting and boiling points of -112°C and 51°C, respectively. Its solubility extends to benzene, chloroform, ether, and petroleum ether. The compound's molecular formula is C2H3ClO, with a molecular weight of 78.50.
Figure 2. Synthesis of Acetyl Chloride
Industrially, acetyl chloride is produced from acetic anhydride and hydrogen chloride, yielding acetyl chloride and acetic acid. Lab-scale synthesis may involve potassium acetate reacting with phosphoryl chloride. Discovered by Charles Gerhardt in 1852, it can also be synthesized using phosphorus trichloride, pentachloride, sulfuryl chloride, phosgene, and thionyl chloride. These methods may introduce impurities that affect reactions. Clean synthesis options include the carbonylation of methyl chloride or the reaction of acetic acid with acetonitrile and hydrogen chloride.
Figure 3. Reactions Involving Acetyl Chloride
Acetyl chloride is used in acetylation reactions to produce esters from alcohols and amides from amines. Reaction with carboxylic acids forms acid anhydrides.
The Schotten-Baumann reaction, which uses bases like triethylamine or sodium hydroxide to neutralize hydrogen chloride, synthesizes esters and amides from alcohols or amines with carboxylic acid chlorides. Depending on the reactivity, sodium bicarbonate or sodium carbonate may be used. Pyridine and 4-dimethylaminopyridine (DMAP) facilitate acetylation of alcohols and amines, acting as catalysts in producing acetylpyridinium salts.
*Including some distributors, etc.
Sort by Features
Sort by Area
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Shandong ThFine Chemical Co., Ltd, established in 2017, based in Zaozhuang, Shandong, China, is a manufacturer of water treatment chemicals. The company’s products portfolio includes polycarboxylic antiscalants and dispersant, biocide and algicide, reverse osmosis chemicals, copper corrosion inhibitors, and oxygen scavengers, among others. The chemicals are applied to circulating boilers and heating water systems in fields and industries such as steel and iron, paper making, petroleum, power plant, and medical, among others. The customer service available includes staff solutions, free samples, and after-sales service.
A.B. Enterprises was established in 1984 and is headquartered in Maharashtra, India. The company is a manufacturer and supplier of general chemicals, specialties, and industrial chemicals to a broad range of industries including food, textile, plastic, rubber, and other industries. The company exports primarily to Canada, Bahrain, and Dubai. The company’s five major product segments include petrochemicals, food chemicals, laboratory chemicals, water treatment chemicals, and fine chemicals. In addition, the company manufactures dentistry materials, pesticides, and chemical supplies.
Hefei TNJ Chemical Industry Co., Ltd, established in 2001, is headquartered in China. The company is a chemical manufacturer and supplier of chemicals to domestic Chinese and global consumers in four primary markets: chemicals, food, pharmaceuticals, and personal care. Chemicals include fine chemicals, agrochemicals, and other chemicals. Food includes agrochemicals, vitamins, amino acids, and food ingredients. Pharmaceuticals include specific chemicals such as Povidone iodine, Clotrimazole crystalline, and Lincomycin. The company also features a CAS databank for CAS-registered chemical compounds.
Aquapharm Chemicals Pvt. Ltd, established in 1974, is an Indian manufacturer based in Pune, Maharashtra, specializing in specialty chemicals. The company’s product range, grouped into four categories, includes acetyl chloride, biodegradable chelating agents, mercaptobenzothiazole (MBT), and phosphonates. These offerings find applications in various industries such as oil and gas, detergent, industrial cleaner, textiles, and water treatment. In 2017, the company inaugurated an innovation center furnished with laboratories engaging in the research and development of chelating and dispersing agents, corrosion inhibitors, and oil field chemicals. The research efforts and the facility itself have garnered recognition from the country’s Department of Science and Technology.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Bhagwati Chemicals was founded in 2002 in Gujarat, India is a manufacturer and exporter of industrial and fine chemicals. The company operates in segments such as industrial acids, safety products, metal pretreatment chemicals, chemical supplies, and organic fertilizers. Their safety products segment includes recyclable driving gloves, shoe covers, and safety coves. The company has grown to incorporate the importation of agrochemicals like potassium humate, amino acid powder, fulvic acid 80%, and seaweed extract flakes from China and Taiwan. The company is a trader and supplier of hydrogen peroxides, formic acid, acetic acid, caustic soda flakes, glycerin, and ethylene glycol.
Ralington Pharma LLP, founded in Gujarat in 2015, India is a manufacturer of pharmaceutical products such as chemicals, natural extracts and pellets. The company's product portfolio includes Active Pharma Ingredients, Specialty Pharmaceuticals, and Generic Pharmaceuticals. The company serves industries such as healthcare, pharmacies, clinical research, and Chemical and Petrochemicals. The company offers customer services that include support, custom research projects and customized services. The company also have microbiological testing services for products and pharmaceutical water, antimicrobial effectiveness tests and method suitability tests.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Keshariya Corporation, established in 1999, and located in Maharashtra, India, is a manufacturer, supplier, and distributor of chemicals. They offer a wide range of chemicals, including chemical powder, liquid chemicals, pharma chemicals, and industrial chemicals. Their products find applications in industries such as oil-field industries, petrochemicals, pharmaceuticals, and water treatment. Keshariya Corporation ensures the quality of its products by partnering with reputed manufacturers and adhering to industry standards. Their products are utilized for process control, and efficient operations in various industrial settings.
RX Chemicals was founded in Mumbai, India, in 2011. RX Chemicals sells chemical-based products for many sectors including automobile, agriculture, airline, medicine, and accessories. Automobile products include carwash shampoo, compressor cleaner, and interior cleaners. Agricultural products include fungicides, herbicides, and pesticides. Airline products include exterior products such as deicing fluid, as well as interior products such as solvent cleaner. The company also provides a range of services including chemical inspection, logistics, chemical usage supervision, as well as tank cleaning.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Vizag Chemical International was founded in Andhra Pradesh, India, in 2011. Vizag Chemical International sells chemical-based products for many sectors including automotive, agriculture, airline, deodorizers, construction chemicals, boat maintenance, degreasers, detergents, drain clean products, greases, personal hygiene, lab chemicals and equipment, fuel treatment, metal treatment, tank cleaners, swimming pool and spa chemicals, scale removers, sewage chemical treatment, as well as raw chemicals. Vizag Chemical International also provides a range of services including chemical inspection, logistics, chemical usage supervision, as well as tank cleaning.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Remedy Labs |
15.0%
|
| 2 | BHAGWATI CHEMICALS |
10.0%
|
| 3 | A. B. Enterprises |
10.0%
|
| 4 | Aquapharm Chemical Pvt. Ltd. |
10.0%
|
| 5 | KESHARIYA CORPORATION |
7.5%
|
| 6 | Ralington pharma LLP |
7.5%
|
| 7 | nacalai |
7.5%
|
| 8 | RXChemicals |
5.0%
|
| 9 | Shandong ThFine Chemical Co., Ltd |
5.0%
|
| 10 | Central Drug House |
5.0%
|
Derivation Method
The ranking is calculated based on the click share within the acetyl chloride page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
6 | 54.5% |
|
Japan
|
3 | 27.3% |
|
China
|
2 | 18.2% |
