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This section provides an overview for phorone as well as their applications and principles. Also, please take a look at the list of 8 phorone manufacturers and their company rankings. Here are the top-ranked phorone companies as of December, 2024: 1.THE BioTek..
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Phorone, commonly known as diisopropylidene acetone, is an organic compound with the formula C9H14O. It features two double bonds within its structure.
The compound is scientifically named 2,6-dimethyl-2,5-heptadien-4-one, and identified by the CAS number 504-20-1.
Phorone is utilized as a powerful glutathione-depleting agent in physiological studies. It can also be derived from certain terpenoid compounds.
Glutathione, a tripeptide composed of glutamic acid, cysteine, and glycine, features a thiol group (-SH group). This group's reducing property allows glutathione to reduce peroxides and reactive oxygen species, maintaining a reducing environment within cells. Moreover, glutathione can conjugate foreign substances, such as toxins and drugs, facilitating their expulsion from the cell.
In physiological research on animals like rats, phorone markedly reacts with glutathione's thiol group. This reaction effectively deactivates glutathione, enabling the study of glutathione deficiency symptoms and its physiological roles and relationships to diseases.
Phorone, with a molecular weight of 138.20, presents as aromatic yellow crystals or a dark yellow liquid at room temperature, with a melting point of 28°C and a boiling point of 198-199°C. It is a flammable substance, having a flash point of 79°C, and is stable under standard storage conditions, although it reacts vigorously with strong oxidizers. Its density is 0.885 g/mL, and it is recommended to keep it away from heat, sparks, and flames due to the risk of hazardous decomposition into carbon oxides.
Available primarily for research and development, Phorone is sold in quantities like 1g and 5g, designed for easy laboratory handling. It finds applications in biochemistry, physiology, and synthetic organic chemistry experiments.
Phorone is synthesized through the self-condensation of acetone in the presence of acidic conditions, such as hydrochloric acid. Initially, two acetone molecules undergo aldol condensation and dehydration to form mesityl oxide. Subsequently, the carbonyl group of mesityl oxide enolates and nucleophilically adds to another acetone molecule, leading to a second aldol condensation and dehydration to yield Phorone. The reaction sequence includes enolization to mesityl oxide, followed by Michael addition, cyclization, and dehydration to produce isophorone.
When condensed with ammonia, phorone forms triacetoneamine, a precursor in synthesizing 2,2,6,6-tetramethylpiperidine, a sterically hindered amine.
While phorone is not specifically classified under GHS or subject to regulations by safety and fire laws, safety precautions are advised. These include installing adequate local exhaust and general ventilation systems and wearing appropriate personal protective equipment like goggles and protective clothing. Immediate washing is recommended upon skin or eye contact.
*Including some distributors, etc.
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ChemScence, LLC., established in 2006, is an American manufacturer based in Monmouth Junction, New Jersey, specializing in building blocks and fine research chemicals. The company offers approximately 45,000 building blocks and intermediates, as well as thin layer chromatography, screening libraries, bioactive small molecules, and isotope compounds. ChemScence also provides dye and biochemical assay reagents, peptides, and natural products like glycosides, and steroids. Catering to a diverse clientele including universities, research institutions, as well as pharmaceutical and biotechnology companies, ChemScence extends its services to include custom chemistry solutions. Furthermore, the company offers technical expertise in the domain of new drug development.
THE BioTek is a manufacturer of monoclonal and polyclonal antibody that was established in 1989 and is headquartered in the City of Industry, California, USA. The company produces, per customization, a wide range of products, including chemical compounds, bioactive reagents, catalysts and ligands, materials science and inhibitors/agonists. Its products are used by a number of industries, as diverse as biotechnology, pharmaceutical, diagnostics, and academic research. THE BioTek also provides a range of services to its customers, including protein crystallization, antibody production and recombinant protein expression.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Combi-Blocks Inc., established in 1997 and headquartered in San Diego, California, USA, is a research-driven manufacturer and global supplier of laboratory reagents. The company specializes in the research, development, and distribution of combinatorial building blocks, organic compounds, and fine chemicals, making them a pivotal player in providing essential materials for scientific research and chemical synthesis worldwide. Its diverse product range encompasses boronic acids, imidazoles, indoles, oxindoles, and nitrobenzenes. These offerings find applications across pharmaceuticals, biotechnology, and various chemical industries.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | THE BioTek. |
100.0%
|
Derivation Method
The ranking is calculated based on the click share within the phorone page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 57.1% |
|
Canada
|
1 | 14.3% |
| United States | 1 | 14.3% |
|
India
|
1 | 14.3% |
