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This section provides an overview for glutathione as well as their applications and principles. Also, please take a look at the list of 38 glutathione manufacturers and their company rankings. Here are the top-ranked glutathione companies as of December, 2024: 1.Spectrum Chemical Mfg. Corp., 2.Capot Chemical Co.,Ltd, 3.Chemlyte Solutions.
Table of Contents
Glutathione (GSH) is a tripeptide consisting of glutamic acid, cysteine, and glycine. The amino group of cysteine and the carboxy group of glutamic acid's side chain form an amide bond. Oxidized glutathione (GSSG) is formed when two molecules of glutathione form a disulfide bond. However, typically, 'glutathione' refers to the reduced form (GSH). Its chemical formula is C10H17N3O6S, and the CAS number is 70-18-8. It appears as a white powdery solid at room temperature, with a melting point of 195°C, soluble in water, and practically insoluble in ethanol and diethyl ether.
Glutathione is used as a reducing agent in synthetic organic chemistry and biochemistry. For example, it is used in elution buffers to elute GST (glutathione S-transferase) fusion proteins from glutathione-agarose beads. In living organisms, it serves as an antioxidant, protecting cells from reactive oxygen species such as free radicals and peroxides. Medications containing glutathione are available in both oral and injectable forms and are used for various conditions, including drug toxicity, acetonemic emesis, metal poisoning, hyperemesis gravidarum, and gestational hypertension.
Glutathione is a tripeptide formed from glutamic acid, cysteine, and glycine, denoted as L-γ-glutamyl-L-cysteinyl-glycine. It is characterized by a γ-glutamyl bond between the γ-carboxy group of glutamate and the α-amino group of cysteine.
Glutathione contains a thiol group on the cysteine residue's side chain. When oxidized, two molecules of reduced glutathione (GSH) form a disulfide bond, converting to the oxidized form (GSSG). In animal cells, it reduces disulfide bonds in cytosolic proteins to cysteines. It also reduces peroxides and reactive oxygen species, playing a key role in removing oxidative stress.
Glutathione acts nucleophilically through the sulfur moiety of the cysteine residue's thiol group. In vivo, it is catalyzed by glutathione-S-transferases (GSTs) to bind to various substances, including poisons, antibiotics, leukotrienes, and prostaglandins, forming conjugates. These conjugates are then expelled from cells, aiding in detoxification.
Glutathione is available as a chemical reagent for research and development as well as a pharmaceutical product in forms like tablets and injections. It is used to replenish glutathione in the human body and detoxify toxins. It is indicated for various conditions, including drug intoxication, acetonemic emesis, and impaired liver function in chronic liver diseases. Available in various quantities for research, such as 10mg to 500g, glutathione requires refrigerated storage to prevent oxidation. Both reduced and oxidized forms of glutathione are available, and it is essential to distinguish between them.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
AdvaCare Pharma USA LLC, founded in 2014, is an American pharmaceutical manufacturer and supplier based in Cheyenne, Wyoming. The company specializes in a wide range of products, including over-the-counter (OTC) medicines, supplements, antimalarial tablets, injections, and oral suspensions. They also offer oncology tablets, injections, and powder for injections, as well as veterinary products and medical devices like injection instruments, diagnostic detection instruments, and skin and wound care products. AdvaCare's products are available under various brands, such as AmoxiCare™ for amoxicillin capsules and AdvaLife™ for supplements.
Solgar Inc., established in 1947 and based in Leonia, New Jersey, United States, is a manufacturer and supplier of nutritional supplements. The company's product range includes general health, bone & joint support, immune support, sleep support, and stress support. These products are used for supporting general well-being, enhancing bone health, boosting the immune system, improving sleep quality, and managing stress. It primarily serves the health and wellness sector. The company's services include the development of nutritional formulas, research in nutrition science, community outreach, and collaboration with organizations like Feeding America.
NutraCap Labs was founded in 2016 and headquartered in Atlanta, Georgia, as a manufacturer and distributor of wellness and fitness supplements. The company specialises in manufacturing Nutraceuticals/Dietary Supplements which consist of encapsulation manufacturing, sports nutrition, raw health powders and product formulations. The company offers clients contract Manufacturing, custom formulation, private labelling, brand design and distribution to help them build their brand. NutraCap Labs is a fully certified GMP compliant and FDA registered company that has a sister company, Active Wholesale USA, through which they market and sell supplements to retail stores worldwide.
NOW Foods was founded in 1968 and is based in Bloomingdale, Illinois. NOW Foods is a manufacturer and distributor of natural foods and supplements all over the globe. NOW Foods provides natural products with clean ingredients, comprehensive testing, and superior manufacturing. They empower healthy living by sharing knowledge on how to make small changes in daily life for a big impact on overall health like at-home workouts, self-care tips, and supplement education, Their product offerings include vitamins, minerals, organic beauty and sports nutrition products. NOW Foods, America’s private nutrition company meets consumers' need for affordable healthy food.
FabriChem, founded in Milford, Connecticut, in 1993 is a supplier of chemical ingredients for raw material sourcing and custom contract manufacturing. The company's product portfolio includes Specialty & Fine Chemicals, Pharmaceutical Ingredients, Biochemicals, Diagnostics & Buffers and Cosmetic & Oral Care Ingredients. The company serves markets such as research centers, testing and diagnostic labs, healthcare and educational institutions. They also provide services such as Product Selection Guidance, quality control and Custom Manufacturing.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Capot Chemical Co.,Ltd was established in 1996 and is a manufacturer of custom synthesis products based in Hanghzhou, P.R. China. The company manufactures various organics products such as boronic acids, unnatural amino acids, cross linkers, chiral building blocks, and heterocyclic compounds. The management of the company have obtained the ISO 9001:2015 standards certification for the safety management system. The company have participated in various exhibitions, such as Chemspec Europe in Basel and CPhI in Barcelona, Shanghai, Milan, and Philadelphia.
Nanjing NutriHerb BioTech Co. Ltd., founded in 2004 and based in Nanjing, China, is a certified manufacturer specializing in botanical extracts. Its product range includes natural Licorice Extract for health supplements, organic Artemisia Annua Extract used in traditional Chinese medicine, potent antioxidant astaxanthin, Milk Thistle Extract with antioxidant and anti-inflammatory properties, and water-soluble food coloring Sodium Copper Chlorophyllin. These products are certified by Kosher, HALAL, EU, and USDA organic. The company's facility holds approvals from SGS and Bureau Veritas, and it's registered with the FDA, ensuring quality and compliance with international standards.
Kyowa Hakko Bio Co., Ltd. was established in 2008 and is based in Tokyo, Japan, as a manufacturer of pharmaceutical raw materials and ingredients. It specializes in manufacturing bulk pharmaceuticals like citicoline, L-glutathione, and L-ornithine aspartate. It also manufactures raw materials for infusions, dietary supplements, and cosmetics, such as amino acids, peptides, oligosaccharides, and nucleic acids. The company is a subsidiary of Kirin Holdings Company and has obtained ISO 22000:2018, ISO/TS 22002-1:2009, and FSSC 22000 certifications. Its manufactured products are utilized in pharmaceuticals, nutritional supplements, industrial, and cosmetics sectors across Japan, China, the USA, Germany, and Italy.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Chemlyte Solutions, which is based in Hangzhou, China, is a supplier of various sorts of chemical solutions like glycinamide hydrochloride and dimethylchloroacetal. The company provides glycinamide hydrochloride, 2-aminoacetaldehyde dimethyl acetal, and dimethylchloroacetal. It also supplies 2-mercaptoethanol, 3-methyl butynol, as well as chloromethyl pivalate. It partners with a multitude of Chinese manufacturers that supply the products for it to sell. It markets its products to various areas, which include Western and Chinese markets, in general.
Skyrun Industrial Co., Ltd, which was founded in 2003 and is located in Nanjing, China, is a manufacturer & supplier of raw pharmaceutical materials. The company fabricates methyl glucose sesquistearate, decyltrimethylammonium chloride, sodium hexamethylene-1,6-bisthiosulfate dihydrate, and vulcanizing agents. It also produces epoxy resin curing agents, 2,3-dimethylbutane, 3,3-dimethyl-1-butene, and S-adenosyl-L-methionine. Its methyl glucose sesquistearate has the advantages of being moderate, having no irritation, strong emulsifying agent, fine stability and is suitable for the manufacture of high-end paste and cream.
Finetech Industry Limited is a manufacturer of organic compounds and intermediates, which was established in 2009 and is based in Wuhan, China. The company makes pyridine compounds, pyran compounds, pyridazine compounds, catalysts and auxiliaries, as well as piperazine compounds. It also crafts active pharmaceutical ingredients, pharmaceutical intermediates, natural extracts, chemical reagents, and pyrimidine compounds. Each of its products that are offered to the customers is available in three packages, which are one gram, five grams, and bulk quantity.
Gihi Chemicals is a manufacturer of nutrition and dietary supplements, which was started in 2010 and is based in Hangzhou, China. The company fabricates dietary supplements, vitamins and minerals, pet nutrition, and natural foods. It also produces cosmetic ingredients, daily fine chemicals, as well as intermediates for active pharmaceutical ingredients. One of its main dietary supplements, palmitoylethanolamide powder, has diverse functions, which include improving the ability of immunity, treating chronic pain, treating epilepsy, cerebral ischemia, and stroke, and treating Alzheimer's disease and Parkinson's disease.
XD BIOCHEM LIMITED is a manufacturer and supplier of biochemical products that was established in 2010 and is headquartered in Nantong China. The company produces more than 2,000 kinds of biochemical products, including Amino Acids and Derivatives, Antibiotics, Biological Buffers, Coloring Agents, Diagnostic Reagents and, Enzymes and Coenzymes. Its products such as Peptide and Peptide Reagents, Pharma Blocks and Intermediates, Photoelectric Materials, Proteins and Vitamins are utilized by researchers, pharmaceutical companies, and academic institutions for various applications. TXD BIOCHEM LIMITED also provides a range of services, including custom synthesis, contract research, process development, solutions and support.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
LEAP CHEM Co., Ltd. is a manufacturer and supplier of chemical products established in 2005 and headquartered in Hong Kong, China. The company offers an extensive range of about 200,000 chemical products, including organic compounds, inorganic compounds, pharmaceutical intermediates, and custom synthesis services. Their products cater to industries such as pharmaceuticals, agrochemicals, electronics, and materials. LEAP CHEM provides chemical solutions and services to its global customers, supporting research, development, and production activities. Additionally, they provide custom synthesis and contract research, sourcing, online orders of small quantities, global supply chain and export, and technical support services.
Lexicare Pharma Pvt. Ltd., established in 2005 in Gujarat, India, is a manufacturer and supplier of pharmaceutical, ayurvedic, veterinary, and nutraceutical solutions, which are categorized into gummies, effervescent tablets, anti-venom serum, anti-cancer medicine, and hormone products. The company's product catalog includes Ginseng softgel capsules, antisnake venom serum, Alpha lipoic acid softgel capsules, growth hormones, and I.V. fluids. It has partnered with freight forwarding agencies that help distribute the products to over 15 countries.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Tianjin YR Chemspec Technology Co., Ltd., established in 2012 and headquartered in Tianjin, China, operates as a manufacturer and distributor of a diverse variety of specialty products, raw materials, additives, intermediates, and solvents worldwide. The company is commonly recognized as a reputable global provider of quality performance raw materials, additives, laboratory and research chemicals, and other fine chemical products. The organization consistently prioritizes the execution of a sustainable development plan, which centers around achieving a harmonious balance between human activities and the natural environment to foster a civilized approach to development.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Xiamen Aeco Chemical Industrial Co., Ltd. was established in 2005 and has grown to become a supplier of chemical products, serving customers in various industries. Xiamen Aeco Chemical Industrial Co., Ltd. is a company based in Xiamen, China. The company specializes in the production and distribution of a wide range of chemical products, including pharmaceutical intermediates, agricultural, and other industrial. Their product line includes agrochemicals, APIs, biocides, catalysts, chemical intermediates, cosmetic raw materials, electronic chemicals, food and feed additives, inorganic chemicals, lubricant additives, organic chemicals, paints and coatings, petrochemicals, polymers, solvents, surfactants, textile auxiliary chemicals, water treatment chemicals, and more.
Xiamen Equation Chemical Co., Ltd., which is situated in Xiamen, China, is a supplier of various kinds of bulk specialty chemicals The company delivers fuel additives, lubricant additives, dyestuff and pigment, plastic and rubber, and plant extracts. It also provides food additives, fish collagen peptides, oilfield chemicals, agrochemical intermediates, and flavor and fragrance. Each category mentioned has a large number of chemical products listed that are intended for industry and life science, in general.
Shandong Minglang Chemical Co., Ltd. is a chemical company was founded in 2014 and located in the chemical industry park of Huantai County, Shandong Province, China The company specializes in the research, development, production, and sale of a variety of chemical products, including plasticizers, solvents, pharmaceutical intermediates, and agrochemicals. This company has developed into a top supplier of chemical products in China. The company's products are used in a wide range of industries, including plastics, coatings, pharmaceuticals, and agriculture and places a strong emphasis on product and has established a management system to ensure its products meet the highest standards.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Carl Roth GmbH + Co. KG |
9.1%
|
| 2 | Spectrum Chemical Mfg. Corp. |
7.3%
|
| 3 | Capot Chemical Co.,Ltd |
5.5%
|
| 4 | MilliporeSigma |
5.5%
|
| 5 | Chemlyte Solutions |
4.5%
|
| 6 | Merck |
4.5%
|
| 7 | Solgar Inc. |
3.6%
|
| 8 | AECOCHEM |
3.6%
|
| 9 | AdvaCare Pharma USA |
3.6%
|
| 10 | Emerald Labs |
2.7%
|
Derivation Method
The ranking is calculated based on the click share within the glutathione page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
China
|
12 | 41.4% |
|
United States of America
|
9 | 31.0% |
|
Japan
|
3 | 10.3% |
|
India
|
2 | 6.9% |
|
Germany
|
1 | 3.4% |
United Kingdom
|
1 | 3.4% |
Netherlands
|
1 | 3.4% |
