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This section provides an overview for isophorone as well as their applications and principles. Also, please take a look at the list of 9 isophorone manufacturers and their company rankings. Here are the top-ranked isophorone companies as of December, 2024: 1.Somu Chemicals and Pharmaceuticals P Ltd., 2.BioCrick, 3.NATIONAL ANALYTICAL CORPORATION.
Table of Contents
Isophorone is an organic compound with the chemical formula C9H14O and a cyclic ketone structure.
It is found naturally in cranberries, and its CAS number is 78-59-1. It has a molecular weight of 138.21, a melting point of -8.1°C, and a boiling point of 215.2°C. It is a clear colorless pale yellow liquid at room temperature.
The odor is described as peculiar. The density is 0.92 g/mL. It is extremely soluble in ethanol, acetone, and ether, and virtually insoluble in water.
The main uses of isophorone are in solvents, paints, and raw materials for agrochemicals. Solvents include adhesives, copolymers, coatings, finishes, and insecticides, while paints include inks, paints, and lacquers.
Other applications include synthetic intermediates, preservatives for wood products, and waterproofing agents for floors. In agriculture, isophorone is used as a solvent for acid amide herbicides. The use of isophorone as a solvent is said to have been discovered in the process of finding a way to treat acetone, a byproduct of the production of phenol by the cumene process.
Isophorone is a synthetic intermediate of isophorone diisocyanate (C12H18N2O2, CAS No.: 4098-71-9), which is known as a raw material for polyurethane resin coatings in the paint field, and isophoronediamine (C10H22N2, CAS No.: 2855-13-2), which is known as a raw material for epoxy resin curing agents in adhesives, CAS No.: 2855-13-2), which is known as a raw material for epoxy resin curing agents in adhesive applications.
Isophorone is a flammable liquid with a flash point of 90°C and a spontaneous combustion point of 462°C. It is stable under normal handling. Although isophorone is considered stable under normal handling, combustion in the event of a fire will produce toxic gases such as carbon monoxide and carbon dioxide.
Since it reacts with strong oxidizers, oxidizing agents, and strong bases, mixing with these substances should be avoided in storage. Note that isophorone dimerizes by undergoing a [2+2] photocycloaddition reaction when exposed to sunlight in aqueous solution.
Isophorone is sold primarily as a reagent product for research and development and as an organic solvent for industrial use. Reagent products are available in a variety of volumes, such as 5mL, 25mL, 100mL, 500mL, and 1L, and are offered in volumes that are easy to handle in the laboratory. These reagent products can be stored at room temperature.
As an industrial solvent, it is sold in large packages to factories. Packages include 1L cans, 4L cans, 18L cans, drums, containers, and tank trucks.
Isophorone is synthesized by the self-condensation of three molecules of acetone. The specific synthetic flow is as follows.
The respective yields of mesityl oxide and isophorone depend on the reaction conditions.
Isophorone is a flammable liquid, as mentioned above, and is therefore a compound designated as a "Hazardous Substance, Class IV, Petroleum No. 3, Hazardous Rank III" under the Fire Service Law.
It is also designated as a "Hazardous and Noxious Substance to be Notified by Name" and "Hazardous and Noxious Substance to be Labeled by Name" under the Industrial Safety and Health Law, and as a "Priority Assessment Chemical Substance" under the Law Concerning the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc., and is also designated under the Marine Pollution Control Law.
*Including some distributors, etc.
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Actylis is based in Port Washington, New York, USA, and is an ISO 13485-certified custom manufacturer of chemical compounds that was established in 1978 as a subsidiary of Aceto. The company mainly produces specialty chemical products for the pharmaceutical, biopharm, and agriscience sectors. These chemical products include cell culture ingredients, active pharmaceutical ingredients (APIs), and buffering salts. It also offers excipients, adenosine for cosmetic ingredients, and vitamins for nutritional supplements. The company operates internationally, with manufacturing facilities in Germany, the United Kingdom, and India. Some of its notable clients include Novartis, Nestlé, and Estée Lauder.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Somu Chemicals and Pharmaceuticals Pvt Ltd is a chemicals and pharmaceuticals manufacturer headquartered in Bengaluru, Karnataka, India and was established in 2009. The company’s main activities include the supply and exportation of pharmaceutical chemicals, pharma ingredients, fine chemicals and nutraceutical products such as N-butyl propionate, coleus forskolin, benzal konium chloride, tetrahydropiperine and tetrahydro curcuminoids. Its products’ application areas include pharma intermediates, agrochemical intermediates, cosmetic intermediates, coatings and paint intermediates. The company is ISO 9001:2004, ISO 14001:2000, and OSHAS 18001 certified, and its products undergo testing for formulation, composition, pH value, color, and toxicity.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Somu Chemicals and Pharmaceuticals P Ltd. |
21.7%
|
| 2 | BioCrick |
21.7%
|
| 3 | NATIONAL ANALYTICAL CORPORATION |
21.7%
|
| 4 | Kishida Chemical Co.,Ltd. |
13.0%
|
| 5 | Junsei Chemical Co.,Ltd. |
8.7%
|
| 6 | Actylis |
4.3%
|
| 7 | KANTO CHEMICAL CO.,INC. |
4.3%
|
| 8 | Merck |
4.3%
|
Derivation Method
The ranking is calculated based on the click share within the isophorone page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 57.1% |
|
India
|
2 | 28.6% |
|
United States of America
|
1 | 14.3% |
