All Categories
History
This section provides an overview for hydroxylamines as well as their applications and principles. Also, please take a look at the list of 31 hydroxylamine manufacturers and their company rankings. Here are the top-ranked hydroxylamine companies as of December, 2024: 1.Santa Cruz Biotechnology, Inc., 2.ebei Nengqian Chemical, 3.Oakwood Products, Inc.
Table of Contents
Hydroxylamine is an inorganic compound with the chemical formula NH2OH.
It is an intermediate in the nitrification process in biosynthesis and is oxidized by hydroxylamine oxidase to produce nitrite. Hydroxylamine is commonly handled in aqueous solution and as salts, including hydrochloride and sulfate.
Hydroxylamine and its salts serve as reducing agents in various organic and inorganic chemical reactions. They are used in synthesizing oximes and caprolactam, a raw material for nylon. Additionally, they function as analytical reagents, enzyme reactivators, de-hairing agents for animal skins, photographic developers, semiconductor cleaners, and raw materials for pharmaceuticals and agrochemicals. Hydroxylamine is also used in tobacco sweeteners, soaps, and as antioxidants and stabilizers for fatty acids. Moreover, it plays a significant role in the nitrogen cycle and wastewater treatment, serving as a biological intermediate in nitrification and anaerobic ammonia oxidation.
Hydroxylamine is a colorless, needle-like crystal, highly deliquescent and volatile. It has a melting point of 91.4 °F (33 °C) and decomposes at 136.4 °F (58 °C). The molar mass of hydroxylamine is 33.030 g/mol, and its density at 68 °F (20 °C) is 1.21 g/cm³.
Hydroxylamine is an unstable substance, gradually decomposing even at room temperature. This decomposition is hastened by moisture and CO2. It can explode when heated or exposed to ultraviolet light, transforming into substances like ammonia (NH3), nitrogen (N2), and nitrous oxide (N2O).
It is soluble in water, liquid ammonia, and methanol, but insoluble in ether, benzene, and chloroform.
Hydroxylamine's structure resembles a combination of water and ammonia. Consequently, liquid hydroxylamine, similar to water, dissolves many inorganic salts.
Hydroxylamine can be synthesized using the Raschig method: reduction of an aqueous solution of ammonium nitrite at 0 °C with HSO4-/SO2 yields hydroxylamide-N,N-disulfate. Upon hydrolysis, this yields the sulfate salt, (NH3OH)2SO4.
Treating this sulfate with liquid ammonia yields solid hydroxylamine. Ammonia can be removed under reduced pressure, leaving behind ammonium sulfate, which is insoluble in liquid ammonia. Other synthetic methods include the production of hydroxylammonium salts and the reduction of nitrite or sodium nitrite by sulfite ions, yielding hydroxylammonium salts.
Hydroxylamine reacts with ketones and aldehydes to form oximes and with chlorosulfuric acid to produce hydroxylamine-O-sulfonic acid. It also reacts with electrophilic reagents like alkylating agents, where both nitrogen and oxygen atoms are subject to electrophilic attack.
Approximately 95% of hydroxylamine is utilized in synthesizing cyclohexanone oxime, a precursor to Nylon 6. Cyclohexanone is converted to cyclohexanone oxime using hydroxylamine sulfate. This oxime undergoes Beckmann rearrangement when treated with acid, forming caprolactam, from which Nylon 6 is synthesized through ring-opening polymerization.
*Including some distributors, etc.
Sort by Features
Sort by Area
Oakwood Chemical is based in Estill, South Carolina. The company is a producer of a wide range of organics with particular emphasis on fluorine and sulfur compounds. The company also offers custom synthesis services and bulk quantities upon request. The company has independent operations and operations in collaboration with the University of South Carolina. The company’s suppliers include ChemCollect, Chess, KISHIDA CHEMICAL Co., Ltd., and Tetramer. The company’s featured products include boronic acids and esters, peptide coupling, fluorinated amines, and reagents for synthesis.
AK Scientific, Inc. (AKS) is an American advanced intermediates and fine chemicals manufacturer that was established in Union City, California in 1997. The company’s product lineup includes chemical biocides, bioactives, inhibitors, and reagents. It also offers a range of products for use in life science applications, such as screening compounds, organoborons, and molecular fluorophores. These are extensively used in agrochemicals, biotech, pharmaceuticals, and nanotechnology. Aside from its products, AKS also offers international procurement and sourcing services to its clients, which include AstraZeneca, Sanofi-Aventis, and Bristol-Myers Squibb.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Creative Safety Supply, LLC, established in 2007 and headquartered in Oregon, United States is a supplier specializing in safety and industrial labeling solutions. The company offers a range of products and services, including safety signs, floor marking tape, and label printers. Catering to various industries, such as manufacturing, warehouses, construction, and logistics, its offerings are used in promoting workplace safety and efficiency. Industries make use of its products and services to ensure clear communication of safety information and to establish visual workplace standards.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Zhengzhou Alfa Chemical Co., Ltd. (ZACC) is a manufacturer of organic chemicals and catalysts established in 2010 and based in Jiaozuo, Henan. The company primarily produces pharmaceutical and organic intermediates as well as photoelectric materials for customers in life science, polymers, dyes, and metallurgy. The company's product lineup includes condensed ring compounds, heterocyclic compounds, COFS/MOFS, and metal catalysts. These supply client corporations such as Bayer AG, Pfizer Inc., and Sumitomo Chemical Company, Ltd. ZACC also offers gram- to ton-level contract synthesis and production services.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
iChemical Wako Pure Chemical Corporation, established in 2008 and headquartered in Shanghai, China, is a manufacturer of industrial chemicals. Its product portfolio includes solvents, catalysts, reagents, and building blocks, along with offerings in pesticides, herbicides, food additives, and surfactants. The company provide services such as custom synthesis, scale-up, punch-out, and procurement outsourcing. The company operates seven offices and logistic hubs, and is connected to 15,000 laboratories and manufacturers, offering a wide portfolio of 380,000 research chemicals. Its products and services have been utilized to groundbreaking scientific discoveries for over 20,000 organizations worldwide.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Henan Tianfu Chemical Co., Ltd., founded in 2009, is a Chinese chemical manufacturer and supplier based in Zhengzhou, Henan. The company has developed over 500 compounds, mostly for fine applications in manufacturing and life science. Their product range includes electronic chemicals, ultraviolet (UV)-curing materials, ionic liquids, and pharmaceutical materials. Additionally, Henan Tianfu has expanded into the fine chemical market, offering noble metal catalysts, organic phosphine ligands, and organic light-emitting diode (OLED) intermediates. They are also involved in the development of pesticides and medical intermediates, as well as the analysis and synthesis of electronic chemical materials.
Angene International Limited is a manufacturer and supplier of chemicals and biochemicals. It is headquartered in Hong Kong and was established in 2009. The company manufactures and supplies a range of chemicals and biochemicals, including organic chemicals, inorganic chemicals, and polymers. Some of its popular products are silane coupling agents, fluoropolymer resins, and methacrylate monomers. Angene International Limited also provides custom synthesis, API, analytical services, and technical support services. Its products are used in various industries, including electronics, plastics, and pharmaceuticals.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Shree Ambica Geotex Pvt. Ltd., founded in 1947 and based in Fukuoka, Japan, is a manufacturer and supplier of HDPE tarpaulins coated with LDPE and various woven sacks. The company manufactures tarpaulins of GSM ranging from 80 to 500 GSM, under the brand name "RAINSHIELD", used in various applications like truck covers, relief tents, agriculture, pond lining and vermibed. It also makes HD/PP woven sacks used for fertilizer, cement or sugar bags. The company's “RAINSHIELD” brand is registered under BIS with IS 7903(HDPE Tarpaulins) and IS 15351(HDPE Woven Geomembrane) standard, and has also obtained ISO certification.
Shreeram Plastic Industries, founded in 1985 and headquartered in Maharashtra, India, is a manufacturer and supplier specializing in the production of tarpaulins and ropes. The company's product portfolio includes HDPE tarpaulins, polypropylene ropes, and tarpaulin covers. These products find applications in various sectors, including agriculture for crop protection, general industrial operations for safeguarding materials, and logistics for securing and transporting goods. The company provides various services, including personalized packaging of products according to customer requirements.
ebei Nengqian Chemical, established in 1998 and headquartered in Xingtai City, China, is a manufacturer and supplier specializing in the production and sale of chemical products. The company's product portfolio includes organic chemicals, inorganic chemicals, pharmaceutical chemicals, agricultural chemicals, and food additives. These products find applications in various industries, including agriculture, pharmaceuticals, cosmetics, chemical manufacturing, and food and beverage. The company provides services including product catalogs, technical support, order processing, customized solutions, and options for custom packaging and labeling for bulk orders or specialized needs.
Sanko Technologies Sdn Bhd, established in 2019 and headquartered in Batu Maung, Malaysia, is a manufacturer and supplier specializing in RF and wireless communication testing instruments and solutions, particularly for Bird. The company's product range includes a modular vector network analyzer, a USB vector network analyzer, a handheld signal generator, a vector signal analyzer, a vector signal generator, and more. These products cater to a diverse range of sectors, including telecommunications, industry, computers, semiconductors, and universities. The company has established a clientele that includes TE Connectivity, Syrma SGS, Rosenberger, Hermeus, and Andhra Electronics Limited.
ALADDIN is a manufacturer and supplier of research and development reagents that was established in Shanghai, China, in 2009. Its biochemical reagents are used in the life sciences, materials science, and chemistry fields. The company manufactures drug target ligands, antibodies, and proteins as well. It also supplies testing services and laboratory equipment for high-end users. It works in technological, biological, and scientific, research too. Its inventory is used in the biological science and analytical chemistry industries.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
MOLBASE, founded in 2013 and headquartered in Shanghai, China, is a supplier of a SaaS-powered and data-driven integrated service platform for chemical e-commerce. Its offered e-commerce platform is designed for small and medium-sized chemical-related businesses, where various activities, including chemical searching, promotion, inquiry, transaction, and payment, can be done. Chemical business owners can design and set up their online stores, manage products and inventory, process orders, build customer relationships, and leverage analytics and reporting on the platform. The company also provides various support services, including supply chain financial services, business intelligence services, and logistics and warehousing services.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Echemi Digital Technology Co. Ltd., started in 2015 and based in Hong Kong, China, is a supplier of chemical raw materials through its B2B digital commerce platform. The company sells products such as propylene carbonate, adipic acid, and oseltamivir phosphate and serves over 100,000 buyers and over 20,000 suppliers in more than 190 countries worldwide. It also provides price and market analysis of over 500 raw materials per week in the areas of coatings, fine chemicals, and pharmaceuticals. It also covers food and nutrition and was ranked 55th in the 2022 ICIS top 100 chemical distributors.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Santa Cruz Biotechnology, Inc. |
13.3%
|
| 2 | ebei Nengqian Chemical |
10.0%
|
| 3 | Oakwood Products, Inc |
10.0%
|
| 4 | Alfa Chemistry |
10.0%
|
| 5 | Wego Chemical Group Inc |
10.0%
|
| 6 | Tokyo Chemical Industry Co., Ltd. |
10.0%
|
| 7 | AK Scientific, Inc |
6.7%
|
| 8 | Pharmaffiliates |
6.7%
|
| 9 | Toronto Research Chemicals |
6.7%
|
| 10 | Parchem |
6.7%
|
Derivation Method
The ranking is calculated based on the click share within the hydroxylamine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
8 | 30.8% |
|
India
|
7 | 26.9% |
|
China
|
4 | 15.4% |
|
Japan
|
2 | 7.7% |
|
United Kingdom
|
2 | 7.7% |
|
Canada
|
1 | 3.8% |
| United States | 1 | 3.8% |
|
Malaysia
|
1 | 3.8% |
