11 Tetrahydropyran Manufacturers in 2024
This section provides an overview for tetrahydropyran as well as their applications and principles. Also, please take a look at the list of 11 tetrahydropyran manufacturers and their company rankings. Here are the top-ranked tetrahydropyran companies as of April, 2024: 1.Tokyo Chemical Industry Co., Ltd., 2.KANTO CHEMICAL CO.,INC., 3.Merck.
Table of Contents
What Is Tetrahydropyran?
Tetrahydropyran is a clear, colorless liquid and a cyclic ether.
Its IUPAC name is oxane, known also as THP, oxacyclohexane, 1-oxacyclohexane, and 1,5-epoxypentane, or pentamethylene oxide.
Uses of Tetrahydropyran
1. Protecting Group
Tetrahydropyran serves as a protective group for alcohols in organic synthesis, converted to tetrahydropyranyl ether under acidic conditions by the action of 2,3-dihydropyran.
The typical procedure involves reacting alcohol with dihydropyran in the presence of p-toluenesulfonic acid in a dichloromethane solvent, with deprotection achieved through acid hydrolysis. When water is unsuitable, alcohol can be used instead.
The 2-tetrahydropyranyl group, stable against bases, nucleophiles, and reducing agents, has drawbacks such as chiral center formation at the 2-position, complicating NMR analysis, and potential diastereomer generation complicating reaction systems.
2. Solvent Applications
As a solvent, tetrahydropyran resists acidic, basic, and reducing conditions, making it suitable for reactions, extractions, and crystallizations. Its resistance under strongly basic conditions surpasses that of tetrahydrofuran, lending to its use in pharmaceutical and agrochemical productions.
Properties of Tetrahydropyran
Chemical formula: C5H10O, molecular weight: 86.13, CAS number: 142-68-7. Liquid at room temperature, melting point: -45 °C, boiling point: 88 °C, density: 0.880 g/ml at 20 °C. It exhibits a volatile, ethereal pungent odor, soluble in many organic solvents and water.
Other Information on Tetrahydropyran
1. Synthesis Methods
Produced by hydrogenating 2,3-dihydropyran with a Raney alloy catalyst or by cyclization and dehydration of 1,5-pentanediol under acidic conditions.
2. Legal and Regulatory Information
Regulated under various laws as a hazardous material and inflammable substance.
3. Handling and Storage Precautions
Use personal protective equipment in ventilated areas, avoid contact with strong oxidizers, and take care to prevent peroxide formation. Highly flammable; store in a cool, well-ventilated place away from ignition sources. In case of fire, use appropriate extinguishing methods. Wear protective clothing to prevent skin and eye exposure, and seek medical advice if irritation occurs.
List of 11 Tetrahydropyran Manufacturers
*Including some distributors, etc.
Sort by Features
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- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- Canada
- India
- Japan
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Synthonix, Inc.
TETRAHYDROPYRAN-3-CARBOXYLIC ACID
Company Overview
Synthonix, Inc., founded in 2003 and located in Wake Forest, North Carolina, USA, is a manufacturer and supplier of chemical research products and solutions. The company specializes in synthetic chemistry, specifically in the design and synthesis of complex molecules and building blocks for pharmaceutical and agrochemical applications. The company’s product line includes stannanes, fused rings, boronic acids, spirocycles, and azides. The company is ISO 9001:20015 certified, ensuring adherence to quality management systems.
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KANTO CHEMICAL CO.,INC.
Tetrahydropyran
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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SimSon Pharma Limited
4-(2-Aminoethyl)tetrahydropyran
Manufacturer Overview
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
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Pharmaffiliates
Tetrahydropyran-2-methanol
Manufacturer Overview
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
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Toronto Research Chemicals
Ezetimibe Tetrahydropyran Impurity
Manufacturer Overview
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
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Tokyo Chemical Industry Co., Ltd.
Tetrahydropyran
Manufacturer Overview
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
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Merck
Tetrahydropyran
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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BLDpharm
Tetrahydropyran-2-methanol
Manufacturer Overview
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
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MilliporeSigma
Tetrahydropyran
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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SynZeal Research Pvt Ltd
Ezetimibe Tetrahydropyran Impurity
Company Overview
SynZeal Research Pvt Ltd, established in 2010 and headquartered in Ahmedabad, Gujarat, is a manufacturer and supplier of pharmaceutical reference standards and research chemicals. The company specializes in producing pharmacopeial and non-pharmacopeial reference standards, drug glucuronides, drug metabolites, isotope-labeled reference standards, and compound libraries, catering to diverse industries and research institutions. It holds ISO 9001-2008 certification and was acknowledged by the Department of Scientific and Industrial Research (DSIR) for its R&D capabilities.
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HAZMAT Resource, Inc.
Tetrahydropyran-4-carboxylic acid, 98%
Distributor Overview
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
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Tetrahydropyran Manufacturer Ranking
*Including some distributors, etc.Ranking as of April 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Tokyo Chemical Industry Co., Ltd. |
33.3%
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| 2 | KANTO CHEMICAL CO.,INC. |
33.3%
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| 3 | Merck |
33.3%
|
Derivation Method
The ranking is calculated based on the click share within the tetrahydropyran page as of April 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
Newly Established Company
- BLDpharm: 2014 (10 years ago)
- SynZeal Research Pvt Ltd: 2010 (14 years ago)
- Synthonix, Inc.: 2003 (21 years ago)
Company with a History
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Tokyo Chemical Industry Co., Ltd.: 1946 (78 years ago)
- Toronto Research Chemicals: 1982 (42 years ago)
Tetrahydropyran Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Tetrahydropyran Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
India
|
3 | 42.9% |
Japan
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2 | 28.6% |
United States of America
|
1 | 14.3% |
Canada
|
1 | 14.3% |
