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This section provides an overview for glutaraldehyde as well as their applications and principles. Also, please take a look at the list of 31 glutaraldehyde manufacturers and their company rankings. Here are the top-ranked glutaraldehyde companies as of December, 2024: 1.ASP Global Manufacturing, GmbH, 2.SMC Global, 3.Spectrum Chemical Mfg. Corp..
Table of Contents
Glutaraldehyde is an organic compound classified as a dialdehyde compound.
Its molecular formula is C5H8O2, and in accordance with IUPAC nomenclature, it is called 1,5-pentanedial.
It has a molecular weight of 100.12, a melting point of -14°C, and a boiling point of 71-72°C. It is a colorless or slightly pale yellow liquid at room temperature. It has a pungent odor. The substance is readily soluble in water, alcohol, and acetone.
It is also highly toxic and irritating, and the development of chemical hypersensitivity has been suggested. Because of these toxic properties, glutaraldehyde is a compound subject to various laws and regulations.
Glutaraldehyde is used as a fixing solution for electron microscopes, as a leather tanning agent, as a fixing agent for paper and plastic, as a cross-linking agent (hardener) for photographic gelatin, and as a developing agent for radiographic photographs.
Because it has two aldehyde groups, it has strong fixing power and is excellent in maintaining the morphology of microstructures. However, because of its weak permeability in tissues, tissue samples are usually limited to 1 mm square. Furthermore, it requires cooling at 4°C for about 1-2 hours.
Because of its strong sterilizing power, it is used as a chemical sterilization and disinfection agent for medical instruments, equipment, and devices, such as endoscopes and surgical instruments. 2% glutaraldehyde solution and 20% glutaraldehyde solution are approved drugs for medical use, and are effective against almost all bacteria, fungi, spores, and viruses. They are effective against almost all bacteria, fungi, spores, and viruses.
In addition, it is also used as an algaecide for cooling towers and as a disinfectant for poultry houses and poultry farming equipment.
Glutaraldehyde is relatively unstable when heated and can polymerize. It can also be converted to glutaric acid through oxidation reactions.
Glutaraldehyde products currently on the market include medical-use pharmaceuticals and reagents for research and development.
As mentioned above, medical-use pharmaceutical products are used as disinfectants for medical instruments, and include 2% glutaraldehyde solution, 20% glutaraldehyde solution, and other types.
Reagent products for research and development are also sold mainly as aqueous solutions, and are available in concentrations of 25% and 50%. The capacities include 25mL, 500mL, 1L, 3L, etc., and are provided in volumes that are easy to handle in the laboratory.
Glutaraldehyde's action as a fixing and sterilizing solution is due to the high reactivity of its aldehyde groups. When used as a fixing solution in the biological field, the main reaction occurs with the ε-amino group of the lysine residue of proteins, but reactions also occur with the α-amino group and SH group.
These will form intermolecular cross-links and function as a fixing solution. In this case, a single molecule of glutaraldehyde does not form a cross-link by itself, but rather a polymer such as a dimer or trimer formed in aqueous solution or an unsaturated aldehyde formed by aldol condensation is considered to be the reaction-active species.
The mechanism of action of glutaraldehyde when used as a fungicide is believed to be the alkylation of the amino group of the cytoplasm by the aldehyde group of glutaraldehyde.
Glutaraldehyde is highly toxic and irritating, and the following toxicities have been reported. Although no clear carcinogenicity has been reported, the occurrence of chemical hypersensitivity similar to formaldehyde has been noted.
*Including some distributors, etc.
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SMC Global is a specialty chemicals manufacturer founded in 1996 and headquartered in New York City, New York. The company primarily serves clients in oil and gas, mining, and consumer electronics. The company's product portfolio includes oilfield chemicals such as surfactans and demulsifiers, agricultural chemicals like pesticides and fungicides, and paint or coating additives like wetting agents and rheology modifiers. SMC Global also offers technical support, custom synthesis and logistics services to its clients, which include Chevron, DuPont, and Dow Chemical.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
ASP Global Manufacturing, GmbH, established in 1987 in Irvine, California, is a manufacturer and supplier of sterilizers. The company offers an extensive and diversified product portfolio, including terminal sterilization products such as the SEALSURE Chemical Indicator (CI) Tape and STERRAD Chemical Indicator (CI) Strips, high-level disinfection solutions like the EVOTECH Endoscope cleaner and Reprocessor, as well as software solutions like ASP ACCESS Technology. These products have applications in various industries, including scientific research institutions, hospitals, pharmaceutical companies, and the food and beverage sector.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Merck KGaA was founded in 1668 and is a manufacturer of medical products and devices based in Darmstadt, Germany. The company manufactures various products such as erbitux, bavencio, tepmetko, glucophage, and eutyhrox. These products are used for various purposes such as general medicine treatments, cardiovascular diseases, childhood growth hormone deficiency, multiple sclerosis treatments, and merkel cell carcinoma. The company has obtained various certifications such as ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, and ISO 50001:2018.
Muscat and Barka Business Trading - MBBT is a manufacturer and supplier of chemicals, based in Muscat, Oman, since 1995. The company produces and supplies chemicals that are used as raw materials for various industries for example Per Chloro Ethylene is used as a dry cleaning agent, chemical intermediate, and for metal degreasing and cleaning, and Lead nitrate is used in the manufacturing of Lead paint, matches, and special explosives. They also specialize in petrochemical and industrial solvents and their other chemicals have uses in the pharmaceutical, food, agro-veterinary, and process industries.
Color Chromes Pvt. Ltd., founded in 1976 and headquartered in West Bengal, India, is an exporter and manufacturer of chromium chemicals for the Metal Finishing industry. The company supplies chromic acid flakes and solution, potassium and sodium chromate, chromium nitrate crystals and solution, and chrome oxide green to a diverse range of industries, including Automobile, Engineering, Defence and Aerospace, Telecommunication, Electronics and Computers. The ISO 9001:2015 certified manufacturing facility is located in Uttar Pradesh, India.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Acuro Organics Limited is a manufacturer and supplier of specialty chemicals based in India. Established in 1971, the company has grown to become a global partner in various industries, including water treatment, oil and gas, agriculture, and personal care. Acuro Organics' extensive product portfolio includes a range of chemicals such as polymers, biocides, enzymes, and specialty chemicals used for water treatment, hygiene, and sanitation applications. With innovation, and sustainability. Acuro Organics provides its customers with products and services that in attaining while protecting the environment.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Hefei TNJ Chemical Industry Co., Ltd, established in 2001, is headquartered in China. The company is a chemical manufacturer and supplier of chemicals to domestic Chinese and global consumers in four primary markets: chemicals, food, pharmaceuticals, and personal care. Chemicals include fine chemicals, agrochemicals, and other chemicals. Food includes agrochemicals, vitamins, amino acids, and food ingredients. Pharmaceuticals include specific chemicals such as Povidone iodine, Clotrimazole crystalline, and Lincomycin. The company also features a CAS databank for CAS-registered chemical compounds.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Innova Corporate is an Indian ISO 9001 certified chemical manufacturer specializing in water, effluent, and sewage treatment products that was established in 2005. Based in New Delhi, the company produces various chemicals for treating soil, water, effluent, and sewage, as well as water softeners and coagulants. They also offer custom solutions for unique customer use cases. Innova Corporate products are primarily used by clients in the wastewater treatment, pharmaceutical, textile manufacturing, and sugar industries.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Shanghai Chemex Group Ltd., based in Shanghai, China, is a manufacturer and supplier of chemical raw materials. The company offers a diverse range of products including water treatment chemicals, food industry chemicals, and agrochemicals. Key offerings include phosphoric acid, potassium carbonate, and HEDP. These chemical compounds play a crucial role in the manufacturing of various goods and products. The company caters to international order and has branches in Istanbul, Dubai, and Moscow.
PANDORA INDUSTRIES PVT. LTD, established in 2017 and based in Delhi, India, is a supplier distributor of industrial chemicals. The company's product range includes monensin sodium, ortho phenyl phenol, acetic acid glacial, copper sulfate, and gentian violet. These products are used for applications in manufacturing and industrial facilities across the country. The company primarily serves industries such as pharmaceuticals, agriculture & poultry feed, water treatment, and cosmetics. Its services include sourcing raw materials, conducting multiple quality checks, ensuring products meet international standards, and final product dispatch.
Kavya Pharma, established in 2009 in Surat, Indian state of Gujarat, is a pharmaceutical manufacturing company that specializes in the production and supply of WHO-GMP certified pharmaceutical products, including Active Pharmaceutical Ingredients (API) and Intermediates. The company offers a range of pharmaceutical medicines, including ichthammol, gentamicin sulfate, neomycin sulfate, and polymyxin b sulfate. In addition to these products, they also manufacture, export, and supply specialty chemicals, pharmaceutical raw materials, API & other bio fertilizer products, poly aluminum chloride, and psyllium herb.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Shiv Shakti India, is a supplier of industrial chemicals and raw materials, was founded in 1999 and is based in Vadodara-Gujarat, India that specializes in the production and export of industrial chemicals. The company is a global supplier of raw materials, with a product range that includes phenolic products, benzalkonium chloride, glycols, and quaternary compounds, catering auxiliary chemicals, construction chemicals, distilled industrial and poultry chemicals and water treatment Chemicals, etc. They also received ISO 9001:2008 and ISO 14001:2004 certification in 2013.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | ASP Global Manufacturing, GmbH |
11.9%
|
| 2 | SMC Global |
8.0%
|
| 3 | Spectrum Chemical Mfg. Corp. |
7.0%
|
| 4 | Junsei Chemical Co.,Ltd. |
6.5%
|
| 5 | MUBY CHEMICALS |
5.5%
|
| 6 | KANTO CHEMICAL CO.,INC. |
5.0%
|
| 7 | Fengchen Group Co.,Ltd |
4.5%
|
| 8 | Carl Roth GmbH + Co. KG |
4.5%
|
| 9 | Wego Chemical Group Inc |
4.0%
|
| 10 | Merck KGaA |
4.0%
|
Derivation Method
The ranking is calculated based on the click share within the glutaraldehyde page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
9 | 33.3% |
|
United States of America
|
6 | 22.2% |
|
Japan
|
4 | 14.8% |
|
China
|
4 | 14.8% |
|
Germany
|
2 | 7.4% |
| Oman | 1 | 3.7% |
| Iran | 1 | 3.7% |
