14 Creatine Manufacturers in 2024
This section provides an overview for creatines as well as their applications and principles. Also, please take a look at the list of 14 creatine manufacturers and their company rankings. Here are the top-ranked creatine companies as of November, 2024: 1.Supplement Manufacturing Partner Inc., 2.Superior Supplement Manufacturing, 3.KANTO CHEMICAL CO.,INC..
Table of Contents
What Is a Creatine?
Creatine is an odorless, white, crystalline powder.
Its chemical formula is C4H9N3O2, molecular weight is 131.13, and its CAS number is 57-00-1, it is also called 2-(1-Methylguanidino)acetic Acid. Creatine occurs naturally in the human body, with more than 90% found in muscle and some in the brain.
The body's total creatine stores are estimated to be about 120 g for an adult weighing 70 kg. Creatine is synthesized in the body from three amino acids (arginine, glycine, and methionine), mainly in the liver and kidneys.
The body synthesizes only about half of the daily requirement of creatine, and any deficiency must be obtained from food or supplements. Creatine is abundant in raw meat and fish, but its content is reduced by cooking.
Uses of Creatines
Creatine is used to resynthesize ATP (a substance found in cells that is necessary to store and use energy used in vital activities), which is the energy used by muscles to contract and is present in muscles as creatine phosphate.
During exercise, the energy generated when ATP is broken down is used, but because there is a limit to the amount of ATP, the resynthesis of ATP by creatine phosphate is necessary for continued exercise. Creatine has the effect of increasing endurance and muscle strength during exercise and other physical activities, so creatine's ability to increase athletic performance is useful mainly during repetitive, short, intense exercise.
In addition to athletes, the effects of creatine on the athletic performance of the elderly are also being studied, and the use of creatine to maintain muscle strength and rehabilitation of the elderly is being investigated.
Properties of Creatines
Creatine has a melting point (decomposition temperature) of 303°C and is slightly soluble in water, but not in ether. Creatine is found in vertebrates and facilitates the recycling of adenosine triphosphate (ATP), primarily in muscle and brain tissue.
Recycling is accomplished by converting adenosine diphosphate (ADP) back to ATP through the donation of phosphate groups. Creatine also acts as a buffer.
Other Information About Creatines
1. Biosynthesis of Creatines
Creatine is an amino acid derivative that is naturally produced in the human body from the amino acids glycine and arginine. In the first step of biosynthesis, the enzyme arginine (glycine amidinotransferase, AGAT) mediates the reaction of glycine and arginine to form guanidinoacetic acid.
This product is then methylated by guanidinoacetic acid N-methyltransferase (GAMT) using S-adenosylmethionine as the methyl donor. Creatine is phosphorylated by creatine kinase to form creatine phosphate, which is used as an energy buffer for skeletal muscle and the brain. A cyclic form of creatine called creatinine exists in equilibrium with its tautomer and creatine.
2. Handling and Storage Precautions
Precautions for handling and storage are as follows
- Keep the container tightly closed and store it in a dry, cool, dark place.
- Use only outdoors or in well-ventilated areas.
- Store away from oxidizing agents and other incompatible materials.
- Be aware that decomposition produces carbon monoxide, carbon dioxide, nitrogen oxides, and other gases.
- Wear protective gloves, eye protection, protective clothing, and protective masks when using.
- Take care not to inhale dust or aerosol.
- Wash hands thoroughly after handling.
- In case of skin contact, flush immediately with water.
- In case of eye contact, rinse cautiously with water for several minutes.
List of 14 Creatine Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- China
- India
- Japan
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Supplement Manufacturing Partner Inc.
Creatine
Manufacturer Overview
Supplement Manufacturing Partner Inc., which is based in Edgewood, United States of America, is a manufacturer of vitamins, supplements, and nutraceuticals. The company fabricates various types of capsules, gummy vitamins, jellybeans, and liquids. It also manufactures a large variety of powders, soft gels, and tablets. Its capsules’ shells can be made to specific designs such as being made out of gelatin or a more vegetarian-friendly formulation. It accepted the Gold Stevie Award for the best manufacturing company of the year in 2021.
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Superior Supplement Manufacturing
Creatine
Company Overview
Superior Supplement mfg firm, established in 2014 and headquartered in California, United States, specializes in various delivery forms and provides services like formulations, research and development, component sourcing, packaging services, printing, label design, and other related offerings. The company manufactures nutritional supplements, that include soft gels, capsules, liquids, gummy tablets, lotions, powders, and different formulations. To package its products, the company utilizes several wrap formats which include sachets, bottles, bags, stick packs, pouches, folder cartons, and blister packs.
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KANTO CHEMICAL CO.,INC.
Creatine monohydrate
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Avanschem
Creatine
Manufacturer Overview
Avanschem, established in 2012, a manufacturer of a wide range of products such as cyanuric acid, pegelatinized sarch, welan gum, and more, operating from a prime location of Gurgaon, Haryana, India. The company provides products developed from of top-notch ingredients and industrial chemicals, for lab and Industrial use. These products formulated using chemical compounds under controlled temperature and pressure conditions at their sophisticated laboratory. They specialize in formulations & contract manufacturing, dossiers services, sourcing services and others, with a worldwide distribution network.
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MUBY CHEMICALS
Creatine
Manufacturer Overview
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
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Hefei TNJ Chemical Industry Co.,Ltd.
Creatine
Manufacturer Overview
Hefei TNJ Chemical Industry Co., Ltd, established in 2001, is headquartered in China. The company is a chemical manufacturer and supplier of chemicals to domestic Chinese and global consumers in four primary markets: chemicals, food, pharmaceuticals, and personal care. Chemicals include fine chemicals, agrochemicals, and other chemicals. Food includes agrochemicals, vitamins, amino acids, and food ingredients. Pharmaceuticals include specific chemicals such as Povidone iodine, Clotrimazole crystalline, and Lincomycin. The company also features a CAS databank for CAS-registered chemical compounds.
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Merck
Creatine monohydrate
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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MilliporeSigma
Creatine monohydrate
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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nacalai
Creatine Monohydrate
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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ALPSPURE LIFESCIENCES PRIVATE LIMITED
Creatine
Company Overview
ALPSURE LIFESCIENCES PVT. LTD., founded in Haryana, India, in 2015 is a manufacturer and distributor of Phytochemicals, Chemicals, Natural Herbal Extracts, and Organic Herbal Extracts. The company's product portfolio includes fruit Extracts Powders, Hadjod Cissus Quadrangularis Extracts, industrial chemicals, Nutraceuticals and dietary supplements and vitamin chemical powders. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Agriculture and healthcare. The company has a global distribution network and a customer support center.
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TCL Ingredients Co., Ltd
Creatine
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Otto Chemie Pvt. Ltd
Creatine
Distributor Overview
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
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Foodchem International Corporation
Creatine
Distributor Overview
Foodchem was founded in 2006 in Shanghai, China. The company is ISO 9001 certified and is a producer, distributor, R&D provider, and marketer of specialty and standard food additives and ingredients to pharmaceutical, cosmetic, nutrition, and chemical industries around the world through distributors and self-managed warehouses. The company operates through four product segments: Food Ingredients, Feed Additives, Industrial Chemicals, and Active Pharmaceutical Ingredients. Certain categories include Kosher and Halal-certified products and products meeting other dietary restrictions.
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Creatine Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Supplement Manufacturing Partner Inc. |
30.6%
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| 2 | Superior Supplement Manufacturing |
15.0%
|
| 3 | Merck |
13.4%
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| 4 | KANTO CHEMICAL CO.,INC. |
11.3%
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| 5 | Avanschem |
5.5%
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| 6 | Hefei TNJ Chemical Industry Co.,Ltd. |
4.6%
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| 7 | MUBY CHEMICALS |
3.6%
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| 8 | TCL Ingredients Co., Ltd |
3.4%
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| 9 | MilliporeSigma |
3.4%
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| 10 | nacalai |
3.1%
|
Derivation Method
The ranking is calculated based on the click share within the creatine page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
- Hefei TNJ Chemical Industry Co.,Ltd.: 210
- Avanschem: 26
Newly Established Company
- ALPSPURE LIFESCIENCES PRIVATE LIMITED: 2015 (9 years ago)
- Chongqing Joywin Natural Products Co., Ltd.: 2013 (11 years ago)
- Avanschem: 2012 (12 years ago)
Company with a History
- nacalai: 1934 (90 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- MUBY CHEMICALS: 1976 (48 years ago)
Creatine Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Creatine Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
India
|
4 | 36.4% |
China
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3 | 27.3% |
United States of America
|
2 | 18.2% |
Japan
|
2 | 18.2% |
