All Categories
This section provides an overview for indoline as well as their applications and principles. Also, please take a look at the list of 38 indoline manufacturers and their company rankings. Here are the top-ranked indoline companies as of December, 2024: 1.Otto Chemie Pvt. Ltd, 2.KANTO CHEMICAL CO.,INC..
Table of Contents
Indoline is a heterocyclic compound known as 2,3-dihydro-1H-indole or 2,3-dihydroindole. It appears as a colorless to dark brown liquid with the chemical formula C8H9N and a molecular weight of 119.16. Its CAS number is 496-15-1, and it is structurally similar to indole (C8H7N) but with a reduction at positions 2 and 3.
The isomer of indoline with the nitrogen atom at position 2 is known as isoindoline.
Indoline has a boiling point of 220°C, a melting point of -21°C, and a specific gravity of 1.063 g/mL at 25°C. It is highly soluble in ethanol and nearly insoluble in water. Compared to indole, indoline is more basic due to its unreduced nitrogen atom, with an acid dissociation constant (pKa) of 5.2.
Indoline is primarily used as an intermediate in the synthesis of pharmaceuticals, agricultural chemicals, dyes, photo-functional materials, and functional resins. It is particularly notable in the production of pigments and dyes and is utilized in electronics, such as in dye-sensitized solar cells.
Indoline can be synthesized via the catalytic reduction of indole. It is obtained by distilling and purifying coal tar, using metal catalysts such as copper chromite, raney nickel, and nickel-titanium. When stored, it should be kept in a well-ventilated, cool place, in a light-shielded, tightly sealed glass container.
Flammability: Indoline is a flammable liquid. Keep it away from heat, sparks, and open flames. In case of fire, use carbon dioxide, powder extinguishers, water spray, foam, or fire sand to extinguish it.
Health Hazards: Indoline is corrosive and irritating to the skin and eyes. Protective clothing, gloves, and eyewear should be worn when handling it. In case of contact, wash the affected area with soap and water and seek medical attention if irritation persists. Use it in a well-ventilated area or a draft chamber to avoid inhalation of vapors.
*Including some distributors, etc.
Sort by Features
Sort by Area
AK Scientific, Inc. (AKS) is an American advanced intermediates and fine chemicals manufacturer that was established in Union City, California in 1997. The company’s product lineup includes chemical biocides, bioactives, inhibitors, and reagents. It also offers a range of products for use in life science applications, such as screening compounds, organoborons, and molecular fluorophores. These are extensively used in agrochemicals, biotech, pharmaceuticals, and nanotechnology. Aside from its products, AKS also offers international procurement and sourcing services to its clients, which include AstraZeneca, Sanofi-Aventis, and Bristol-Myers Squibb.
ReagentWorld is a US-based manufacturer of chemicals and laboratory supplies founded in 1993 and headquartered in Ontario, California. The company specializes in over 50,000 organic and inorganic chemicals, chromatographic and biochemical reagents, solvents, and solutions. It also offers labware supplies like beakers, pipettes, precision balances, pumps, and spectrometers. It provides specialty chemicals, custom synthesis, and contract manufacturing for high-purity products. The company caters to the biotechnology, pharmaceuticals, food and beverage, polymer processing, and industrial markets worldwide.
ChemScence, LLC., established in 2006, is an American manufacturer based in Monmouth Junction, New Jersey, specializing in building blocks and fine research chemicals. The company offers approximately 45,000 building blocks and intermediates, as well as thin layer chromatography, screening libraries, bioactive small molecules, and isotope compounds. ChemScence also provides dye and biochemical assay reagents, peptides, and natural products like glycosides, and steroids. Catering to a diverse clientele including universities, research institutions, as well as pharmaceutical and biotechnology companies, ChemScence extends its services to include custom chemistry solutions. Furthermore, the company offers technical expertise in the domain of new drug development.
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Spectrum Laboratory Products, Inc., established in 1971 in New Brunswick, NJ, is a manufacturer and supplier of fine chemicals, laboratory supplies, APIs, and equipment that are ISO 9001:2015 certified. The company makes chemicals such as controlled substances, colorants, oils, flavors and fragrances, and bases. It also supplies capsule machines, glassware washers, ointment mills, compounding essentials, and syringes. Its New Jersey and California plants are FDA registered, while the China lab is ISO 17025 certified.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Ambeed, established in 2015 and headquartered in Arlington Heights, Illinois, is a manufacturer and supplier of catalog products, including inhibitors, natural products, nucleotides, building blocks, and amino acids. The company mainly specializes in organoboron, metal catalysts, heterocyclic building blocks, and materials science-related products. Its catalog has more than 100,000 in-stock products, increasing monthly. As of 2019, the company’s R&D center had developed five product lines with over 600,000 products. The company provides pre-sale and after-sale services and works with distributors from several countries, including India, Pakistan, Egypt, Poland, and Brazil.
Finetech Industry Limited is a manufacturer of organic compounds and intermediates, which was established in 2009 and is based in Wuhan, China. The company makes pyridine compounds, pyran compounds, pyridazine compounds, catalysts and auxiliaries, as well as piperazine compounds. It also crafts active pharmaceutical ingredients, pharmaceutical intermediates, natural extracts, chemical reagents, and pyrimidine compounds. Each of its products that are offered to the customers is available in three packages, which are one gram, five grams, and bulk quantity.
iChemical Wako Pure Chemical Corporation, established in 2008 and headquartered in Shanghai, China, is a manufacturer of industrial chemicals. Its product portfolio includes solvents, catalysts, reagents, and building blocks, along with offerings in pesticides, herbicides, food additives, and surfactants. The company provide services such as custom synthesis, scale-up, punch-out, and procurement outsourcing. The company operates seven offices and logistic hubs, and is connected to 15,000 laboratories and manufacturers, offering a wide portfolio of 380,000 research chemicals. Its products and services have been utilized to groundbreaking scientific discoveries for over 20,000 organizations worldwide.
Hangzhou Dayangchem Co.Limited is a manufacturer and supplier of fine chemicals and pharmaceutical intermediates, headquartered in Hangzhou, Zhejiang, China. Its product range covers organic compounds, Active Pharmaceutical Ingredients (APIs), nutritional products, and custom synthesis. Some of its products are heterocyclic compounds, aromatic compounds, boronic acids, amino acids, and organometallic compounds. These products are used for developing various drugs, agrochemicals, dyes, flavors, and fragrances for different markets such as pharmaceutical, biotechnology, cosmetic, and food industries. The company holds ISO 9001:2008 certification for its quality management system.
Sincere Chemical, established in 2001 and located in Shijiazhuang City, China, is a manufacturer that specializes in the production and sales of pharmaceutical intermediates. The company's main products include glacial acetic acid, hydrochloric acid, ammonium hydroxide, nitric acid, and sodium hypochlorite. It also offers customized products such as custom-designed wood boxes, custom mini oak barrels for packaging, and custom-burned logo camping wood boxes. It offers preponderant pricing for its products, making it an affordable option for customers. It serves various industries, including the chemical, paint and coating, agriculture, and manufacturing industries.
Wuhan Fortuna Chemical Co., Ltd., established in 2006 and headquartered in Wuhan, China, is a manufacturer that engaged in organic and fine chemical products, laboratory chemicals, and chemical wholesale products. The company offers a range of products, including flunixin meglumine, amitraz, sodium hyaluronate, carprofen, and cottonseed oil. It also provides custom-tailored products according to client's requirements. Its Antioxidant 245 has low volatility, which means it does not evaporate easily. The company has achieved ISO9001 and GMP certification. Its products are exported to South Korea, Vietnam, Australia, Europe, and South America.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Manchester Organics Ltd., established in 1996 and headquartered in Cheshire, England, is a manufacturer of organic building blocks, intermediates & research chemicals. The company offers over 50,000 building blocks and fine organic chemicals. It specializes in fluorination technology and general organic synthesis at all scales and provides a chemically diverse range of custom synthesis services, development and scale-up projects. The company has multiple milligram to multi-kilo production facilities with high pressure capability and cGMP specialist fluorination facility.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Angene International Limited is a manufacturer and supplier of chemicals and biochemicals. It is headquartered in Hong Kong and was established in 2009. The company manufactures and supplies a range of chemicals and biochemicals, including organic chemicals, inorganic chemicals, and polymers. Some of its popular products are silane coupling agents, fluoropolymer resins, and methacrylate monomers. Angene International Limited also provides custom synthesis, API, analytical services, and technical support services. Its products are used in various industries, including electronics, plastics, and pharmaceuticals.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
FUJIFILM Wako Pure Chemical Corporation, established in 1922 and headquartered in Osaka, Japan, is a manufacturer and supplier of laboratory chemicals, specialty chemicals, and diagnostic reagents. Its product range encompasses Azo Polymerization Initiators, Photo-Initiators, Polymerization Inhibitors, Resin Modifiers, and Pharmaceutical and Cosmetic Materials, which find applications in diverse fields like research, and testing. The company operates multiple manufacturing facilities in Aichi, Harima, Tokyo, and the USA, with its adherence to quality exemplified by its ISO/IEC 17025 certification.
Hangzhou Longshine Bio-Tech Co., Ltd., established in 2011 and headquartered in Hangzhou, Zhejiang, China, is a manufacturer and supplier of pharmaceutical and chemical goods. The company offers a wide range of products, including API and intermediates, conjugated estrogens, beta-alanine, adrenaline tartrate, and 5-bromopyridine-2-carbaldehyde. These chemical products serve various purposes, such as being potent orally active estrogen receptor antagonists with anticancer properties, regulating animal physiology, diagnosing animal diseases, and providing treatments for conditions like erectile dysfunction.
Zehao Industry Co., Ltd., established in 2010 and headquartered in Jinan City, Shandong Province, China, is a manufacturer and supplier of chemical products. The company specializes in producing a wide range of chemicals, including pharmaceutical intermediates, agrochemicals, and specialty chemicals. The company serves industries such as pharmaceuticals, agriculture, and manufacturing, providing essential components for various applications. It also customizes high-value-added chemicals and intermediates for the customer. The company is ISO 9001:2015 certified, ensuring adherence to quality management systems.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Combi-Blocks Inc., established in 1997 and headquartered in San Diego, California, USA, is a research-driven manufacturer and global supplier of laboratory reagents. The company specializes in the research, development, and distribution of combinatorial building blocks, organic compounds, and fine chemicals, making them a pivotal player in providing essential materials for scientific research and chemical synthesis worldwide. Its diverse product range encompasses boronic acids, imidazoles, indoles, oxindoles, and nitrobenzenes. These offerings find applications across pharmaceuticals, biotechnology, and various chemical industries.
Accela ChemBio Co., Ltd., founded in China in 2007, is a supplier of customized services for synthesizing milligrams to kilograms of building blocks including intermediates of Protacs, sugars, and ADCs. The company specializes in the production of intermediates required for the development of Proteolysis Targeting Chimeras (Protacs), a cutting-edge approach in drug discovery. It serves industries such as pharmaceutical, biotechnology, and chemical research and it has sales offices and warehouses in San Diego, CA (USA) and Shanghai (China). "
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Discovery Fine Chemicals, founded in 2006 and based in Dorset, UK, is a supplier of biochemicals and life science products. The company provides antibiotics, APIs, buffers, carbohydrates, detergents & enzyme substrates for microbiology, diagnostics, research and production. It has a portfolio of nearly 600 compounds comprising antibiotics, antibacterials and antifungals that are held in stock in pack sizes ranging from 10mg up to multi kilo packs. The company's products are ISO 9001-2015 certified, and are meant to be used in microbiology, food microbiology, public health, universities and diagnostics.
Carbanio, established in 2015 and based in Hyderabad, India, is a supplier of chemicals. The company procures and sells products such as active pharmaceutical ingredients, API impurities, additives, petrochemicals, and organic solvents. There are around 1.7 M products available with this company, all of which are CAS-registered. The company also buys and sells chemicals to various industries such as laboratories, pharma, and other industries. Apart from this, the company also sells flavors and fragrances, organometallic compounds, and lithium reagents.
Watson International Limited, founded in 1996, and headquartered in London, England, is a professional fine chemical supplier. The company is capable in the development of both natural and unnatural amino acids, along with amino alcohols. Additionally, it offers custom synthesis services for carbohydrates, including carbohydrate-based intermediates, carbohydrate-based drugs, and glycosidase substrates. As the business department of the FCAD Group, the company serves as a crucial intermediary between research and development (R&D), production, and market demand. Leveraging the research and development capacity of FCAD, it caters to several industries, including pharmaceuticals, healthcare, electronics, and personal care.
ChemSrc, established in 2014, is a supplier of pharmaceutical products, a chemical database platform, and a search engine. This platform serves as a gateway to an extensive repository of chemical knowledge, offering access to unique CAS-encoded product records including synthesis routes, literature references, physical and chemical properties, and supplier information. The chemical catalog spans various categories, including organic raw materials, dyes and pigments, chemical pesticides, catalysts, additives, and more. The repository information plays a vital role in supporting research and development efforts across diverse industries by fostering scientific advancements and serving as a valuable resource.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Otto Chemie Pvt. Ltd |
66.7%
|
| 2 | KANTO CHEMICAL CO.,INC. |
33.3%
|
Derivation Method
The ranking is calculated based on the click share within the indoline page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
China
|
8 | 28.6% |
|
United States of America
|
7 | 25.0% |
|
Japan
|
4 | 14.3% |
|
United Kingdom
|
4 | 14.3% |
|
India
|
3 | 10.7% |
| United States | 1 | 3.6% |
|
Canada
|
1 | 3.6% |
