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This section provides an overview for anthranilic acid as well as their applications and principles. Also, please take a look at the list of 21 anthranilic acid manufacturers and their company rankings. Here are the top-ranked anthranilic acid companies as of December, 2024: 1.Cambridge Isotope Laboratories, Inc., 2.The Pherobase, 3.Tokyo Chemical Industry Co., Ltd..
Table of Contents
Anthranilic acid is an organic compound with the chemical formula C7H7NO2. It is also known as 2-aminobenzoic acid, carboxyaniline, 1-amino-2-carboxybenzene, among other names. Its CAS registration number is 118-92-3.
It has a molecular weight of 137.13, a melting point of 146-148 °C, and a boiling point of 200 °C. Anthranilic acid appears as a white or pale yellow crystalline powder at room temperature. It is odorless but has a sweet taste. Its density is 1.412 g/mL, and it has acid dissociation constants pKa of 2.17 (amino group) and 4.85 (carboxyl group).
Anthranilic acid is soluble in hot water, ethanol, and ether.
Anthranilic acid forms insoluble chelates with metal ions such as cadmium and cobalt. It is used in the determination of these metal ions and as a synthetic intermediate in dye and pigment synthesis, including indigo. For example, the diazo coupling reaction with dimethylaniline enables the synthesis of methyl red, an azo dye.
Derivatives of anthranilic acid are used in various applications. For instance, its ester compound with methanol is used as a flavoring agent.
Calcium anthranilic acid is used industrially as a raw material for acridine production.
Anthranilic acid undergoes various chemical reactions. Methyl red can be prepared from it by diazotization followed by a reaction with dimethylaniline.
It can also react with ethyl chloroformate or undergo a reaction with sodium anthranilate and phosgene to produce isatoic anhydride.
Anthranilic acid is available for research and development purposes in various volumes such as 25g, 100g, and 500g. It is sold as a reagent that can be stored at room temperature.
In industrial and synthetic chemistry, anthranilic acid is synthesized through the Hoffman rearrangement of phthalimides with hypochlorous acid, or by reducing o-nitrobenzoic acid.
Known as vitamin L1 for its lactogenic effect on mammals, anthranilic acid is synthesized in vivo from chorismic acid and glutamine by anthranilic acid synthase in the shikimic acid pathway. It is also biosynthesized from kynurenine in the kynurenine pathway, a metabolic pathway of tryptophan. Anthranilic acid is a precursor to various alkaloids. Methyl anthranilate, an ester of anthranilic acid and methanol, is an aroma component found in grapes and jasmine.
*Including some distributors, etc.
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Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Cambridge Isotope Laboratories (CIL) established in 1981, is a global supplier of stable isotopes and labeled compounds, headquartered in the United States. The company provides of products for research, environmental analysis, and medical applications.Their comprehensive product offerings include isotopically labeled standards, biochemicals, and gases, catering to many industries and scientific communities, with partnerships worldwide. They specializes in the process of labeling biochemical and organic compounds with highly enriched, stable (nonradioactive) isotopes of carbon, hydrogen, nitrogen and oxygen.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Anax Laboratories, established in 2012 and headquartered in Hyderabad, Telangana, India, is a manufacturer of chemical solutions and related products. The company specializes in the synthesis of a wide range of organic compounds to cater to the needs of the pharmaceutical and chemical industries. Its product line includes chemicals such as impurities, APIs and intermediates, and research chemicals and building blocks. The company is accredited with ISO, FDA, GMP, and Dun & Bradstreet, ensuring the safety of products and quality management systems.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Honeywell, founded in 1906, in Wabash, Indiana is manufacturer of automotive parts, building technologies, and performance and safety materials for aerospace, The company's product portfolio includes electronic guidance systems, cockpit instrumentation, lighting, automotive parts, and primary propulsion and secondary power turbine engines. The company serves industries such as Oil and Gas, Aerospace and Defense, Automotive and Transportation, Construction, and Power Generation. Their headquartere is located in Carolina and they have global sales offices and distributions channels.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Taj Pharmaceuticals Limited, established in 1995 and headquartered in Mumbai, India, is a global manufacturer and supplier of generic medicines, healthcare, and other products. The company markets more than 500 branded and 4600 generic compositions to consumers in over 40 countries and territories across the globe. Its products cover a vast array of therapeutic categories, and offers an extensive range of dosage forms and delivery systems including oral solids, controlled-release, and steriles. Some of its offerings are diabetic care products, insulin, and growth hormones. The company holds the ISO 9001:2000 certification for its quality management system.
Shanghai QualityWell Industrial Co., Ltd, established in 2008 and based in Shanghai, China, is a manufacturer and supplier of industrial instrumentation. The company's product range includes bimetal thermometers, tridicator-boiler gauges, remote reading thermometers, digital thermometers, and surface thermometers. These products are used for diverse measurement and monitoring needs. It primarily serves the European, Middle Eastern, and North American markets. Its services include research & development for custom applications, technical support, shipping assistance, and the provision of custom manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Bertin Technologies SAS, founded in France in 1956, is a supplier of bioreagent and bioanalytical tools. The company offers a comprehensive range of high-quality bioreagents, including antibodies, enzymes, proteins, nucleic acids, and more, to support molecular biology, genomics, and proteomics research. In addition, it produces bioanalytical tools that encompass a wide variety of instruments and kits designed for applications such as genomics, proteomics, cell analysis, and drug discovery. It has operational subsidiaries in Europe and the United States.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Cambridge Isotope Laboratories, Inc. |
16.7%
|
| 2 | The Pherobase |
11.1%
|
| 3 | Tokyo Chemical Industry Co., Ltd. |
11.1%
|
| 4 | Junsei Chemical Co.,Ltd. |
11.1%
|
| 5 | Anax Laboratories |
5.6%
|
| 6 | Taj Pharmaceuticals Limited |
5.6%
|
| 7 | Cayman Chemical Company |
5.6%
|
| 8 | Honeywell |
5.6%
|
| 9 | Spectrum Chemical Mfg. Corp. |
5.6%
|
| 10 | Kishida Chemical Co.,Ltd. |
5.6%
|
Derivation Method
The ranking is calculated based on the click share within the anthranilic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 35.7% |
|
United States of America
|
3 | 21.4% |
|
India
|
2 | 14.3% |
|
France
|
2 | 14.3% |
|
China
|
1 | 7.1% |
|
United Kingdom
|
1 | 7.1% |
