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This section provides an overview for phthalimide as well as their applications and principles. Also, please take a look at the list of 13 phthalimide manufacturers and their company rankings. Here are the top-ranked phthalimide companies as of December, 2024: 1.Explicit Chemicals Pvt. Ltd., 2.Fengchen Group Co.,Ltd, 3.Jigs chemical.
Table of Contents
Phthalimide, appearing as a white to pale yellow crystalline powder, is known chemically as 1H-Isoindole-1,3(2H)-dione or 1,3-dioxoisoindoline. It plays a crucial role in various organic syntheses.
Phthalimide serves as a precursor in the synthesis of primary amines, photo-enhanced reactions, and as a protective group for primary amines. It's also utilized in producing N-halogen compounds, anthranilic acid, amino acids, phthalocyanine dyes, and serves roles in disinfection and reaction inhibition.
Phthalimide is pivotal for synthesizing primary amines, avoiding the formation of secondary or tertiary amines through nucleophilic substitution reactions and subsequent deprotection with hydrazine.
It facilitates the Mitsunobu reaction for converting hydroxyl groups to amino groups with stereo inversion, leveraging its imide structure to reduce acidity and enable the reaction.
Phthalic anhydride reacts with primary amines to form phthaloyl-protected amines, safeguarding against acid, base, and oxidative conditions, with hydrazine commonly used for deprotection.
N-bromophthalimide and N-chlorophthalimide are synthesized from phthalimide for use as halogenating agents. Additionally, phthalimide is a starting material for dyes, pigments like indigo, and methyl red through the Beckmann rearrangement.
With a molecular weight of 147.13 and a CAS number of 85-41-6, phthalimide has a melting point of 233-237°C and exhibits sublimation. It's soluble in sodium hydroxide solution but insoluble in water, ethanol, and acetone. Its acid dissociation constant (pKa) of 8.3 reflects its acidic strength.
Produced by heating phthalic anhydride with ammonia or related compounds, phthalimide can be purified by recrystallization.
Handle with care to avoid reactions with strong oxidizers and ensure proper personal protective equipment is worn. In case of fire, use appropriate extinguishing methods. For skin or eye contact, immediate washing and medical consultation are advised. Store in a cool, ventilated area away from direct sunlight and in light-shielding containers to prevent degradation.
*Including some distributors, etc.
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Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Forbes Pharmaceuticals was founded in 1980 and is headquartered in Maharashtra, India. The company is a manufacturer, trader, supplier, and exporter of a wide assortment of specialty chemicals that are used in a diverse range of industries. The company conducts research and development in-house to continually increase product offerings at a lower cost to consumers. The company’s product categories include various organic and inorganic compounds as well as chemical supplies including sulfates, nitrates, nitrites, carbonates, and oxides.
Explicit Chemicals Pvt. Ltd., founded in India, is a manufacturer of drug intermediates and specialty chemicals like sodium lauryl sulfate, barbituric acid, alloxan, and monohydrate. The company's product portfolio includes specialty chemicals that span various applications, including agrochemicals, dyes, polymers, and more. It also offers custom synthesis services, allowing clients to request the development of proprietary chemical compounds tailored to their unique requirements. The company serves markets such as pharmaceutical, chemical manufacturing, and agrochemicals.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Hi-Purity Chemicals Pvt Ltd., founded in 1988 and headquartered in Navi Mumbai, India, is a manufacturer and supplier of various chemicals. Its product catalogs include 1-chloro methyl naphthalene, para chloro meta cresol, 1-bromo naphthalene, dichloro meta xylenol, and 4-chloro benzaldehyde, a high purity tech grade chemical used as an intemediate for the manufacture of dyestuffs, optical brighteners, and metal finishing products. The company's products are utilized across various industries, including water and sewage treatment, oil refineries, leather preservation, cooling towers, and surgical disinfection.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Kavya Pharma, established in 2009 in Surat, Indian state of Gujarat, is a pharmaceutical manufacturing company that specializes in the production and supply of WHO-GMP certified pharmaceutical products, including Active Pharmaceutical Ingredients (API) and Intermediates. The company offers a range of pharmaceutical medicines, including ichthammol, gentamicin sulfate, neomycin sulfate, and polymyxin b sulfate. In addition to these products, they also manufacture, export, and supply specialty chemicals, pharmaceutical raw materials, API & other bio fertilizer products, poly aluminum chloride, and psyllium herb.
RX Chemicals was founded in Mumbai, India, in 2011. RX Chemicals sells chemical-based products for many sectors including automobile, agriculture, airline, medicine, and accessories. Automobile products include carwash shampoo, compressor cleaner, and interior cleaners. Agricultural products include fungicides, herbicides, and pesticides. Airline products include exterior products such as deicing fluid, as well as interior products such as solvent cleaner. The company also provides a range of services including chemical inspection, logistics, chemical usage supervision, as well as tank cleaning.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Explicit Chemicals Pvt. Ltd. |
16.2%
|
| 2 | Fengchen Group Co.,Ltd |
10.8%
|
| 3 | Jigs chemical |
10.8%
|
| 4 | Forbes Pharmaceuticals |
10.8%
|
| 5 | MUBY CHEMICALS |
10.8%
|
| 6 | MilliporeSigma |
10.8%
|
| 7 | ISHITA INDUSTRIES |
8.1%
|
| 8 | Hi-Purity Chemicals Pvt Ltd. |
5.4%
|
| 9 | RXChemicals |
5.4%
|
| 10 | Central Drug House |
5.4%
|
Derivation Method
The ranking is calculated based on the click share within the phthalimide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
8 | 80.0% |
|
Japan
|
2 | 20.0% |
