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This section provides an overview for agmatine as well as their applications and principles. Also, please take a look at the list of 12 agmatine manufacturers and their company rankings. Here are the top-ranked agmatine companies as of December, 2024: 1.Altis Endurance LLC, 2.NutraBio Labs, Inc., 3.GAT Sport.
Table of Contents
Agmatine, an organic compound with the molecular formula C5H14N4, plays a role in the biosynthesis of polyamines and is considered a potential neurotransmitter. Its CAS number is 306-60-5, and it is also known as N-(4-aminobutyl) guanidine, among other aliases.
Produced in the brain and stored in synaptic vesicles, agmatine is found naturally in fish and sake, particularly synthesized by koji mold from arginine.
Agmatine's physiological effects include muscle strengthening by serving as a precursor to nitric oxide, enhancing mental wellness by increasing NRF2, promoting muscle growth through elevated testosterone levels, and boosting appetite via neuropeptide Y activation. Its potential in treating various conditions like depression, neuralgia, and neurodegenerative diseases, among others, has been supported by preclinical studies, making it a promising ingredient in dietary supplements.
At room temperature, agmatine is a solid with a molecular weight of 130.195, melting at 102°C and boiling at 281°C. It dissolves in water, has a density of 1.02 g/mL, and features a base dissociation constant (pKb) of 0.52.
Primarily sold as agmatine sulfate, agmatine is available for research and industrial purposes. It is provided in various forms, including salts like agmatine dihydrochloride, and volumes ranging from small to large for laboratory and industrial use.
For R&D, agmatine sulfate and other forms are crucial due to their modulatory effects on neurotransmitters, ion channels, and nitric oxide synthesis. These are available in quantities suitable for lab use and can also be part of screening libraries for drug discovery.
As an industrial chemical, agmatine sulfate serves as a fine chemical and pharmaceutical intermediate, available in bulk quantities for manufacturing processes.
Agmatine sulfate, with a molecular weight of 228.27 and a melting point of 234-238°C, appears as a white powder and is identified by the CAS number 2482-00-0.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MilliporeSigma |
16.0%
|
| 2 | Altis Endurance LLC |
12.0%
|
| 3 | NutraBio Labs, Inc. |
12.0%
|
| 4 | GAT Sport |
12.0%
|
| 5 | Alfa Aesar, Thermo Fisher Scientific. |
12.0%
|
| 6 | HAZMAT Resource, Inc. |
8.0%
|
| 7 | Tokyo Chemical Industry Co., Ltd. |
8.0%
|
| 8 | GLPBIO Technology LLC |
8.0%
|
| 9 | Tocris Bioscience. |
4.0%
|
| 10 | MedChemExpress |
4.0%
|
Derivation Method
The ranking is calculated based on the click share within the agmatine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
5 | 71.4% |
|
Japan
|
1 | 14.3% |
|
United Kingdom
|
1 | 14.3% |
