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This section provides an overview for hypophosphorous acid as well as their applications and principles. Also, please take a look at the list of 9 hypophosphorous acid manufacturers and their company rankings. Here are the top-ranked hypophosphorous acid companies as of December, 2024: 1.Richman Chemical Inc, 2.Merck, 3.Solvay SA.
Table of Contents
Hypophosphorous acid, with the molecular formula H3PO2, is known for its potent corrosive properties, capable of causing blindness and skin irritation upon contact. Its CAS registration number is 6303-21-5.
Valued for its reducing power, hypophosphorous acid's primary applications include roles as a reducing agent in electroless plating, a catalyst in organic synthesis, a surface treatment agent, an antioxidant, and a thermal change inhibitor. It also serves as a bleaching and decolorizing agent for synthetic fibers and plastics and as a precursor for phosphinic acid salts and various substances used as dispersants, emulsifiers, and wet antistatic agents.
This inorganic acid has a molecular weight of 66.00, melts at 26.5°C, and boils at 130°C. Appearing as a clear, colorless oily liquid or solid at room temperature, its density is 1.493 g/mL and an acid dissociation constant (pKa) of 1.2. Hypophosphorous acid is soluble in water, alcohols, and ethers, and decomposes into phosphoric acid and phosphine when heated.
Available as an industrial chemical and R&D reagent, hypophosphorous acid is sold in 30% or 50% solutions. Industrial grades often come in 25 kg polyethylene cans or 200 L drums, catering to various applications. For research purposes, smaller quantities such as 25g, 100g, and 500g solutions are common, with storage recommendations at room temperature.
The synthesis involves boiling phosphorus in an alkaline solution to form a hypophosphorous acid solution. Precipitation of phosphorous acid salts as calcium salts removes them, followed by treatment with a non-oxidizing strong acid (e.g., sulfuric acid) to yield hypophosphorous acid.
Hypophosphorous acid, favoring the HP(O)(OH)2 tautomeric form for its stability, showcases its reducing power by converting chromium(III) oxide to chromium(II) oxide. Upon heating to about 110°C, it decomposes into phosphorous acid and phosphine. It reacts violently with alkaline substances and metals, necessitating careful storage away from high temperatures, sunlight, and moisture.
Identified as hazardous, hypophosphorous acid can cause metal corrosion, serious skin burns, and eye damage. While not classified under specific laws, it is regulated as a corrosive substance for transportation and storage. Appropriate handling measures, including personal protective equipment, are essential to prevent skin, eye, and clothing contact.
*Including some distributors, etc.
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Richman Chemical Inc, Established in 1988 in Pennsylvania, is a manufacturer in the chemical industry. The company serves as a custom synthesis, chemical manufacturing, and raw materials sourcing provider to the life science and chemical sectors. With life science, specialty chemicals, and emerging technologies, Richman Chemical offers tailored solutions, including custom manufacturing, product sourcing, and project management. Operating primarily in North America, the company streamlines project management, reducing costs and accelerating time-to-market for clients' products. Their expertise in custom manufacturing and chemical sourcing positions them as a worthy partner for various industries
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Honeywell, founded in 1906, in Wabash, Indiana is manufacturer of automotive parts, building technologies, and performance and safety materials for aerospace, The company's product portfolio includes electronic guidance systems, cockpit instrumentation, lighting, automotive parts, and primary propulsion and secondary power turbine engines. The company serves industries such as Oil and Gas, Aerospace and Defense, Automotive and Transportation, Construction, and Power Generation. Their headquartere is located in Carolina and they have global sales offices and distributions channels.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Solvay was born in 1863 and is headquartered in Brussels, Belgium. The company is a producer of advanced materials and specialty chemicals to customers worldwide in several markets including the automotive, healthcare, aerospace, and electronics markets. The company’s product offerings range from amines to surfactants with kitting options available for certain materials such as film and tape process materials. The company sources many materials from renewable sources. The company’s cellulose acetate is produced from bio-sourced wood pulp from sustainably managed forests.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Merck |
23.5%
|
| 2 | Richman Chemical Inc |
21.6%
|
| 3 | Solvay SA |
11.8%
|
| 4 | Wego Chemical Group Inc |
9.8%
|
| 5 | Parchem |
7.8%
|
| 6 | Honeywell |
7.8%
|
| 7 | KANTO CHEMICAL CO.,INC. |
7.8%
|
| 8 | nacalai |
5.9%
|
| 9 | MilliporeSigma |
3.9%
|
Derivation Method
The ranking is calculated based on the click share within the hypophosphorous acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 50.0% |
|
Japan
|
2 | 33.3% |
|
Belgium
|
1 | 16.7% |
