7 Rifampicin Manufacturers in 2024
This section provides an overview for rifampicin as well as their applications and principles. Also, please take a look at the list of 7 rifampicin manufacturers and their company rankings. Here are the top-ranked rifampicin companies as of November, 2024: 1.Santa Cruz Biotechnology, Inc., 2.Merck, 3.MedChemExpress.
Table of Contents
What Is Rifampicin?
Rifampicin, also known as rifampin, is an antibiotic with the chemical formula C43H58N4O12 and a molecular weight of 822.94. It appears as a reddish-brown to orange-red crystal or crystalline powder. Rifampicin is insoluble in water, acetonitrile, methanol, and ethanol, but is soluble in chloroform.
It is known for its broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. Rifampicin is primarily used to treat infections such as tuberculosis and leprosy. It is often used in combination with other antituberculosis drugs to prevent the development of drug resistance.
Rifampicin is produced by semi-synthesis from rifamycin, a compound produced by the actinomycete Streptomyces mediterranei.
Uses of Rifampicin
Rifampicin is used as an antibiotic to treat various bacterial infections, including pulmonary tuberculosis, non-tuberculous mycobacteriosis, and leprosy. It works by inhibiting bacterial RNA synthesis, targeting RNA polymerase.
Common side effects of rifampicin include renal failure, interstitial nephritis, shock, anaphylaxis, nausea, stomach pain, vomiting, anorexia, and diarrhea.
Properties of Rifampicin
Rifampicin is a yellow-orange crystalline powder with poor solubility in water but solubility in alcohol and acetone. It is sensitive to heat and light, requiring careful storage. Rifampicin exhibits potent activity against Mycobacterium tuberculosis and other bacteria.
- Mode of Action: Rifampicin inhibits bacterial RNA transcription by acting on RNA polymerase, thereby stopping bacterial growth.
- Antimicrobial Resistance: To minimize the emergence of resistant strains, rifampicin is usually combined with other antituberculosis drugs.
- Pharmacokinetics: Rifampicin is rapidly absorbed from the gastrointestinal tract after oral administration, with peak blood levels reached within 2-4 hours. It is metabolized in the liver and excreted primarily in urine.
- Side Effects: Common side effects include liver damage, jaundice, rash, fever, and gastrointestinal symptoms. Serious side effects are rare but can include allergic reactions and liver damage.
Structure of Rifampicin
Rifampicin has a complex structure featuring a naphthoquinone skeleton, an ansamycin ring, and a piperazine acid-bonded structure. The ansamycin ring contributes to its lipophilicity and facilitates passage through bacterial cell membranes, while the piperazine acid moiety is the active site that targets bacterial RNA polymerase.
Other Information on Rifampicin
Manufacturing Process of Rifampicin
Rifampicin was originally isolated from the actinomycete Streptomyces mediterranei. Current production methods include both biological and chemical semi-synthetic processes. The most common method involves culturing Streptomyces mediterranei and extracting and purifying rifampicin from the culture medium.
List of 7 Rifampicin Manufacturers
*Including some distributors, etc.
Sort by Features
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- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- Japan
- United Kingdom
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MedChemExpress
Rifampicin
Manufacturer Overview
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
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Santa Cruz Biotechnology, Inc.
Rifampicin
Company Overview
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
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PhytoTech Labs
Rifampicin
Company Overview
PhytoTech Labs, founded in 1997, is a manufacturer and distributor of plant research and laboratory products. The company is located in Lenexa, Kansas, and runs a European Union distribution center. They mainly supply kits, reagents, and equipment to those who deal with plant biotechnology, tissue culture, and science. They also distribute to firms involved with molecular biology, plant pathology, and defense. Additionally, they custom-manufacture several media like a woody plant, seed testing, and orchid, for clients to aid in their production and research.
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Merck
Rifampicin
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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MilliporeSigma
Rifampicin
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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nacalai
Rifampicin
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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Alfa Aesar, Thermo Fisher Scientific.
J60836 Rifampin, Molecular Biology Reagent
Company Overview
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
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Rifampicin Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Santa Cruz Biotechnology, Inc. |
50.0%
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| 2 | Merck |
15.6%
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| 3 | MedChemExpress |
12.5%
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| 4 | MilliporeSigma |
12.5%
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| 5 | PhytoTech Labs |
6.3%
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| 6 | nacalai |
3.1%
|
Derivation Method
The ranking is calculated based on the click share within the rifampicin page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
- nacalai: 1934 (90 years ago)
Company with a History
- nacalai: 1934 (90 years ago)
Rifampicin Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Rifampicin Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
United States of America
|
3 | 60.0% |
Japan
|
1 | 20.0% |
United Kingdom
|
1 | 20.0% |
