13 Piperazine Manufacturers in 2024
This section provides an overview for piperazine as well as their applications and principles. Also, please take a look at the list of 13 piperazine manufacturers and their company rankings. Here are the top-ranked piperazine companies as of November, 2024: 1.JOSHI AGROCHEM PHARMA PVT LTD, 2.MilliporeSigma, 3.Kishida Chemical Co.,Ltd..
Table of Contents
What Is Piperazine?
Piperazine, a heterocyclic amine with the formula C4H10N2 and a molecular weight of 86.14, is found in various forms including its hexahydrate C4H10N2.6H2O. It forms salts such as citrate and adipate, used in medical and industrial applications.
Uses of Piperazine
Piperazine salts are employed as parasiticides against pinworms and roundworms in animals, acting on GABA receptors to paralyze these parasites for expulsion. It is known for its strong basicity, moisture absorption, and reaction with carbon dioxide.
Properties of Piperazine
This colorless crystal dissolves in water and ethylene glycol but not in diethyl ether. It forms a basic aqueous solution, absorbing moisture and carbon dioxide from the air. Piperazine's structure, replacing two methylene groups in cyclohexane with NH, creates a piperazine ring.
Other Information on Piperazine
1. Synthetic Method of Piperazine
Piperazine is synthesized via the reduction of pyrazine, the reaction of 1,2-dichloroethane with ammonia, or the dehydration condensation of ethylene glycol and 1,2-diaminoethane.
2. Reaction of Piperazine
Its amino groups react with carbon dioxide to form carbamates or bicarbamates, affecting its solubility and volatility.
3. Carbon Dioxide Recovery With Piperazine
As part of amine mixtures, piperazine enhances carbon dioxide capture in industrial processes due to its stability and efficiency, especially when used with methyl diethanolamine.
4. Pharmaceuticals Containing Piperazine Rings
Many drugs feature piperazine rings, including phenylpiperazine and benzylpiperazine, highlighting its significance in pharmaceutical chemistry.
List of 13 Piperazine Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- China
- India
- Japan
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Parchem
Piperazine
Distributor Overview
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
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Junsei Chemical Co.,Ltd.
Piperazine
Manufacturer Overview
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
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Kishida Chemical Co.,Ltd.
Piperazine
Manufacturer Overview
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
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Hanhong Medicine Technology Co., Ltd.
Piperazine
Manufacturer Overview
Hanhong Medicine Technology (Hubei) Co Ltd., established in 2006 in Wuhan, Hebei Province, China, is a manufacturer, exporter, and importer of pharmaceutical intermediates, industrial chemicals, and chemical auxiliaries. The company produces BMK glycidic acid, BOC piperidone, API raw materials, phenylamino piperidine, and phenyl powder used in the food, pharmaceutical, and chemical markets. It exports 80% of its products to Europe and America, with the remaining 20% going to South Africa, the Middle East, and Southeast Asia.
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MilliporeSigma
Piperazine
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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Hunan Yunbang Pharmacy Co., Ltd
Piperazine
Manufacturer Overview
Hunan Yunbang Pharmacy Co., Ltd. has been a manufacturer specializing in the research and development of pharmaceutical raw materials, intermediates, and fine chemicals in Changsha High-tech Industrial Park, Hunan, China, since 2021. The company products include trometamol hydrochloride, acetate salt, biological buffer, acetic acid, and Mopso sodium salt. It also produces raffinose pentahydrate, Isodulcit Monolydrate, Mometason E Furoate Hydrate, esomeprazole sodium, and umeclidinium bromide used in life sciences, chemicals, organic, and pharmaceutical industries.
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nacalai
Piperazine, Anhydrous
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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Shandong Deshang Chemical Co., Ltd.
Piperazine
Company Overview
Shandong Deshang Chemical Co., Ltd., established in 2022, is a manufacturer and supplier of pharmaceutical raw materials and intermediates in Jinan, Shandong, China. The company's products are organic raw materials, chemical reagents, cosmetic raw materials, daily chemicals, and additives. It also produces flavors, chemical auxiliaries, inorganic chemicals, pigments, and dyestuffs used in pharmaceutical, chemical, and raw material industries. The company exports products to South America, Africa, Eastern Asia, Eastern Europe, and Oceania.
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AFINE CHEMICALS LIMITED
Piperazine
Company Overview
AFINE CHEMICALS LIMITED is a manufacturer, distributor, and supplier of APIs in Sandou Town, Hangzhou, China, founded in 2005. The company has two product categories: the fine chemical department and the pharmaceutical department. The fine chemical category has optical brighteners and auxiliaries such as solvent dyes, pigments, reactive dyes, and basic dyes. The pharmaceutical department produces active ingredients, feed additives, and intermediates such as ibandronate sodium, maprotiline hydrochlorid, calcitonin salmon, zofenopril calcium, and ebastine.
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JOSHI AGROCHEM PHARMA PVT LTD
piperazine
Company Overview
Joshi Agrochem Pharma, established in 1971 and based in Mumbai, India, is a manufacturer, supplier, and exporter of various chemicals, solvents, and metals. The company maintains a stock of agro fertilizers, pesticides, and pharmaceuticals. It has a readily available inventory of 2,000 products, including agrochemicals, solvents, and APIs. These products are utilized in a range of industries, such as automobile, aerospace, and agriculture. The company holds ISO 9001 and ISO 14001 certification and operates as part of the Joshi Group of companies, which is comprised of four companies that are segmented to ensure smooth business in varying domains.
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Jinan Shengqi Pharmaceutical Co., Ltd.
Piperazine citrate
Company Overview
Jinan Shengqi Pharmaceutical Co., Ltd., established in 2014, is a manufacturer, researcher, and supplier specializing in APIS, fine chemicals enterprises, and intermediates in Jinan, Shandong, China. The company produces ketorolac tromethamine, piperazine citrate, O-methylisourea hemisulfate, 2-chloro-n acetamide, and 5 fluorouracil used in chemical, health, and pharmaceutical industries. It has an established research center, functions lab, and a workshop. The company sells the products locally and in foreign markets such as North America, Asia, Europe, Africa, and Oceania.
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Henan Guange Biotechnology Co., Ltd.
Piperazine
Company Overview
Henan Guange Biotechnology Co., Ltd., founded in 2022, is a manufacturer and supplier of fine chemical products in Zhengzhou, Henan, China. The company products are peptides, chemical pesticides, organic intermediates, food additives, and flavors used in the food, chemical, pharmaceutical, and agriculture industries. It also produces ethyl glycidate, BMK liquid, powder lmidazole imidazole, piperonyl butoxide, and Tianeptine sulfate. The company's products are exported to Europe, Southeast Asia, America, Oceania, and Africa.
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Adani Pharmachem Private Limited
Piperazine
Company Overview
Adani Pharmachem Private Limited is a supplier, manufacturer, and exporter of an array of chemicals in Rajkot, Gujarat, India, founded in 1981. The company portfolio has citrate derivatives, iodines, spice oleoresin, active pharmaceutical ingredients, and piperazine derivatives. It also produces veterinary bulk drugs and phosphating chemicals used in pharma formulation, antibiotic manufacturing, drug intermediates, laboratory reagents, and veterinary formulation. The company is ISO 9001:2015 certified and has a State GMP certificate.
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Piperazine Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | JOSHI AGROCHEM PHARMA PVT LTD |
21.9%
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| 2 | MilliporeSigma |
17.2%
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| 3 | Kishida Chemical Co.,Ltd. |
10.9%
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| 4 | Hunan Yunbang Pharmacy Co., Ltd |
9.4%
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| 5 | AFINE CHEMICALS LIMITED |
7.8%
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| 6 | Parchem |
7.8%
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| 7 | Hanhong Medicine Technology Co., Ltd. |
6.3%
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| 8 | Adani Pharmachem Private Limited |
6.3%
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| 9 | Junsei Chemical Co.,Ltd. |
4.7%
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| 10 | nacalai |
4.7%
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Derivation Method
The ranking is calculated based on the click share within the piperazine page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- Kishida Chemical Co.,Ltd.: 283
- Junsei Chemical Co.,Ltd.: 171
- JOSHI AGROCHEM PHARMA PVT LTD: 25
Newly Established Company
- Hanhong Medicine Technology Co., Ltd.: 2012 (12 years ago)
- Parchem: 1999 (25 years ago)
- Adani Pharmachem Private Limited: 1981 (43 years ago)
Company with a History
- nacalai: 1934 (90 years ago)
- Junsei Chemical Co.,Ltd.: 1948 (76 years ago)
- JOSHI AGROCHEM PHARMA PVT LTD: 1971 (53 years ago)
Piperazine Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Piperazine Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
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China
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4 | 44.4% |
Japan
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3 | 33.3% |
United States of America
|
1 | 11.1% |
India
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1 | 11.1% |
