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This section provides an overview for naphthoquinone as well as their applications and principles. Also, please take a look at the list of 10 naphthoquinone manufacturers and their company rankings. Here are the top-ranked naphthoquinone companies as of December, 2024: 1.Actylis, 2.nacalai, 3.City Chemical LLC..
Table of Contents
Naphthoquinone is an organic compound consisting of two oxygen atoms bonded to naphthalene, forming a quinone structure.
There are mainly two types of naphthoquinones: 1,4-naphthoquinone and 1,2-naphthoquinone, with 1,4-naphthoquinone being the more prevalent variant.
1,4-naphthoquinone, a yellow triclinic crystal at room temperature, resembles benzoquinone in aroma. It is insoluble in water but dissolves in various polar solvents. This compound exhibits acidic and oxidizing properties.
To prevent oxidation, 1,4-naphthoquinone should be stored in containers that are shielded from light and air. It can irritate the skin and mucous membranes, hence requires cautious handling. Its industrial synthesis involves the oxidation of naphthalene with a catalyst.
Naphthoquinone serves as a precursor in synthesizing chemicals for diverse industrial uses. Through the Diels-Alder reaction with 1,3-dienes, anthraquinones are produced, which are vital for dye production and serve as a catalyst in pulp manufacturing.
Its diazo derivative, DiazoNaphthoquinone, is employed in the semiconductor industry for mercury exposure. Various naphthoquinone derivatives exhibit cytotoxic properties, making them useful in antiviral and antipyretic medications.
Reports highlight the antibacterial, antifungal, antiviral, anti-inflammatory, and anticancer effects of 1,4-naphthoquinone and its derivatives, leading to the development of new drugs. Their potent coloring properties also make them valuable as dyes and pigments, especially for red and yellow colors.
As a naphthalene derivative, 1,4-naphthoquinone is characterized by its yellow-to-orange crystalline form and distinctive odor. It has a melting point of around 124°C and boils at over 300°C.
Its solubility in water is minimal, but it readily dissolves in polar organic solvents like alcohols, ethers, and acetone. The compound's quinone structure enables easy reduction to a hydroquinone form, and it is prone to oxidation in air, necessitating careful storage.
The structure of 1,4-naphthoquinone features carbonyl groups at the 1 and 4 positions of naphthalene, forming a planar, conjugated system. This structural arrangement allows for the absorption of ultraviolet and visible light, making it suitable for use in dyes and pigments.
Its molecular formula is C10H6O2, with the IUPAC name "4H-cyclopenta[def]phenanthrene-4,5-dione." The compound's structure is foundational to several biologically significant compounds, including vitamin K and ubiquinone (coenzyme Q).
The primary source of 1,4-Naphthoquinone is naphthalene, converted to Naphthoquinone using oxidizing agents like sodium chromate. Other synthesis methods include the ring condensation of anthraquinone derivatives and the oxidation of 1,4-naphthol.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
City Chemical LLC. was founded in 1997 and is a manufacturer and supplier of chemical products based in West Haven, Connecticut, United States. The company's product portofolio includes ammonium fluoride, silicon acetate, potassium manganate, silicon bromide, and barium cyanide. The products are used in various industries such as military, aerospace, semiconductor, and research and development. The MOCVD, CVD, and ALD products lineup are used in the semiconductor sectors for producing micro and nano electronics thin films.
Actylis is based in Port Washington, New York, USA, and is an ISO 13485-certified custom manufacturer of chemical compounds that was established in 1978 as a subsidiary of Aceto. The company mainly produces specialty chemical products for the pharmaceutical, biopharm, and agriscience sectors. These chemical products include cell culture ingredients, active pharmaceutical ingredients (APIs), and buffering salts. It also offers excipients, adenosine for cosmetic ingredients, and vitamins for nutritional supplements. The company operates internationally, with manufacturing facilities in Germany, the United Kingdom, and India. Some of its notable clients include Novartis, Nestlé, and Estée Lauder.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Air Water Performance Chemical Inc. was established in 2021 and is based in Kanagawa, Japan, as a petrochemical products manufacturer. It manufactured phthalic anhydride, monosodium succinate, naphthoquinone, sodium acetate, and calcium acetate solution. Its manufactured products cater to pharmaceuticals, agricultural, electronics, and automobile industries across Japan. The company is part of the Air Water Group and a member of Air Water Inc., and in April 2023, it merged with Air Water Bellpearl Inc. It has obtained ISO 9002 and ISO 14001 certifications and received the Japan Chemical Industry Association Technology Award for developing new manufacturing methods for tetrahydroanthraquinone and anthraquinone.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Actylis |
50.0%
|
| 2 | nacalai |
20.0%
|
| 3 | City Chemical LLC. |
10.0%
|
| 4 | Biosynth |
10.0%
|
| 5 | Air Water Performance Chemical Inc. |
10.0%
|
Derivation Method
The ranking is calculated based on the click share within the naphthoquinone page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 42.9% |
|
Japan
|
3 | 42.9% |
|
Switzerland
|
1 | 14.3% |
