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This section provides an overview for iodobenzene as well as their applications and principles. Also, please take a look at the list of 16 iodobenzene manufacturers and their company rankings. Here are the top-ranked iodobenzene companies as of December, 2024: 1.Seema FineChem Industry LLP, 2.Parchem, 3.Tokyo Chemical Industry Co., Ltd..
Table of Contents
Iodobenzene is an organic compound with the chemical formula C6H5I, classified as an organic halide.
This compound is synthesized by the reaction of benzene with iodine or sulfur iodide and nitric acid under heating conditions.
It is recognized as a flammable liquid, acutely toxic (oral), and an eye irritant under the Globally Harmonized System (GHS). Additionally, iodobenzene falls under hazardous and toxic substances in the Industrial Safety and Health Law and is designated as Hazardous Substance Class 4 and Petroleum No. 3 in the Fire Service Law. It is commercially available for various applications.
Iodobenzene serves as a crucial synthetic intermediate in organic chemistry, particularly useful in reactions involving the phenyl group—a structure prevalent in many natural and synthetic compounds.
It is employed as a substrate in palladium-catalyzed cross-coupling reactions and in the formation of Grignard reagents through its reaction with magnesium.
With a melting point of -29°C and a boiling point of 188°C, iodobenzene appears as a clear, colorless to reddish-brown liquid, possessing a volatile, distinct odor and becomes reddish over time. It is soluble in organic solvents but insoluble in water.
Upon exposure, iodine is released, and iodobenzene can react with metallic sodium to synthesize biphenyl or with sodium hydroxide to form phenol. Its carbon-iodine bond is weaker than those in chlorobenzene and bromobenzene, making it highly reactive for introducing phenyl groups into target molecules.
Iodobenzene features a benzene ring where one hydrogen atom is substituted with an iodine atom. It has a molar mass of 204.01 g/mol and a density of 1.831 g/cm3.
Apart from the primary method, iodobenzene can also be synthesized through the Sandmeyer reaction, which involves diazotizing aniline and then adding potassium iodide with copper salts as catalysts. This process starts with the formation of diazonium salts from aromatic amines and sodium nitrite in a hydrochloric acid solution under cold conditions. The subsequent exchange with potassium iodide and temperature increase leads to nitrogen gas release and iodobenzene formation. Purification involves base neutralization of excess nitrite, followed by acidification and steam distillation of the iodobenzene.
Reacting iodobenzene with magnesium produces phenylmagnesium iodide, a Grignard reagent acting as a synthetic phenyl anion. This makes phenylmagnesium iodide interchangeable with phenylmagnesium bromide in synthetic applications.
Iodobenzene is a preferred substrate for palladium-catalyzed cross-coupling reactions, including the Sonogashira coupling and the Heck reaction. The Sonogashira coupling, which synthesizes alkynylated aryl compounds from an aryl halide and a terminal alkyne, utilizes a palladium catalyst, a copper catalyst, and a base. The Heck reaction, also known as the Mizoroki-Heck reaction, involves the substitution of an alkene's hydrogen atom with an aryl or alkenyl halide in the presence of a palladium catalyst and a base.
*Including some distributors, etc.
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Ambeed, established in 2015 and headquartered in Arlington Heights, Illinois, is a manufacturer and supplier of catalog products, including inhibitors, natural products, nucleotides, building blocks, and amino acids. The company mainly specializes in organoboron, metal catalysts, heterocyclic building blocks, and materials science-related products. Its catalog has more than 100,000 in-stock products, increasing monthly. As of 2019, the company’s R&D center had developed five product lines with over 600,000 products. The company provides pre-sale and after-sale services and works with distributors from several countries, including India, Pakistan, Egypt, Poland, and Brazil.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
FabriChem, founded in Milford, Connecticut, in 1993 is a supplier of chemical ingredients for raw material sourcing and custom contract manufacturing. The company's product portfolio includes Specialty & Fine Chemicals, Pharmaceutical Ingredients, Biochemicals, Diagnostics & Buffers and Cosmetic & Oral Care Ingredients. The company serves markets such as research centers, testing and diagnostic labs, healthcare and educational institutions. They also provide services such as Product Selection Guidance, quality control and Custom Manufacturing.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Infinium Pharmachem Pvt. Ltd., established in 2003 and headquartered in Gujarat, India, is a manufacturer specializing in the development, production, and global export of Iodine Derivatives. Its derivatives find applications in pharmaceutical, chemical, biotech, and related industries worldwide. Its product range encompasses Iodine, Iodate, Iodide, and Tolune which serve as key starting materials in pharmaceutical ingredient manufacturing. The company adheres to quality and sustainability, holding certifications such as ISO-9001-2015 and ISO-14001-2015. The company plays a significant role in the supply of synthesized impurities, metabolites, intermediates, and APIs through custom synthesis.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
GODO SHIGEN Co., Ltd. established in 1934, and based in Chosei-mura, Chiba Prefecture, Japan, is a manufacturer and supplier of iodine and its related compounds. The company's product range includes Inorganic Iodine Compounds, Organic Iodine Compounds, products for the Iodine Recycling Business, and Natural Gas solutions. These products are used in chemical processes, pharmaceuticals, recycling applications, and energy production. The company primarily serves the chemical, pharmaceutical, recycling, and energy industries. Additionally, it offers iodine business services, iodine compound solutions, iodine recycling, and natural gas business solutions.
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Seema FineChem Industry LLP |
28.6%
|
| 2 | Tokyo Chemical Industry Co., Ltd. |
28.6%
|
| 3 | MilliporeSigma |
28.6%
|
| 4 | Parchem |
14.3%
|
Derivation Method
The ranking is calculated based on the click share within the iodobenzene page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 25.0% |
|
India
|
3 | 25.0% |
|
Japan
|
3 | 25.0% |
|
United Kingdom
|
2 | 16.7% |
|
Switzerland
|
1 | 8.3% |
