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This section provides an overview for anisol as well as their applications and principles. Also, please take a look at the list of 12 anisol manufacturers and their company rankings. Here are the top-ranked anisol companies as of December, 2024: 1.Manus Aktteva Biopharma LLP, 2.Clean Science and Technology Limited.
Table of Contents
Anisol, with the chemical formula C7H8O, is also known as methyl phenyl ether or anisole. This organic compound is recognized for its role as an insect pheromone and is characterized by its sweet aniseed scent.
For safe storage, anisol should be kept tightly sealed in a cool, well-ventilated area, away from direct sunlight, high temperatures, sparks, flames, and static electricity. It is advisable to avoid mixing with strong oxidizing agents. Anisol is classified as a hazardous and flammable substance.
Anisol serves multiple purposes, including as an organic solvent, synthetic intermediate, anthelmintic, soap, industrial fragrance, and raw material for economical fragrances. Its ortho- and para-directive reactivity with acetic anhydride to produce p-methoxyacetophenone, a compound used for its floral fragrance or flavor, is particularly notable.
Furthermore, anisol can react with disulfuric dirine pentasulfide to produce Lawson's reagent, a sulfidizing agent capable of replacing oxygen atoms with sulfur atoms in organic compounds, with the chemical formula [(CH3OC6H4)PS2]2.
Anisol, a colorless liquid with a pleasant aroma, has a melting point of -37.5°C and boils at 155.5°C. It mixes well with ethanol and diethyl ether but is nearly insoluble in water. Its relatively low toxicity, with an LD50 in rats of 3,700 mg/kg, contrasts with its main hazard of flammability, highlighted by a low flash point of 52°C.
Due to the electron-donating methoxy group's resonance effect, anisol exhibits a high electron density on the benzene ring, favoring ortho-para orientation in electrophilic reactions. The Hammett constants are -0.268 for the para effect and +0.115 for the meta effect.
Anisol's structure features a benzene ring with one hydrogen atom replaced by a methoxy group (–OCH3), combining a methyl group (-CH3) and a phenyl group (-C6H5) through an ether bond (-O-). Its molar mass is 108.14 g/mol, with a density of 0.995 g/mL.
Anisol can be synthesized through the reaction of dimethyl sulfate with phenol in an alkaline solution, or via the Williamson synthesis involving sodium phenoxide and a methyl halide.
Besides forming p-methoxyacetophenone when reacted with acetic anhydride, anisol can engage in various chemical reactions, including the formation of π-complexes with metal carbonyls and the production of Lawson reagent through the reaction with diphosphorus pentasulfide (P4S10). The stability of anisol's ether bond contrasts with the methyl group's susceptibility to removal by hydroiodic acid, and its Birch reduction yields 1-methoxycyclohexa-1,4-dienes.
*Including some distributors, etc.
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Stratechem (I) Pvt. Ltd., founded in India in 1976, is a manufacturer of pure aromatic like Mentha Arvensis Oil, Menthol Crystals, and Mentha Piperita Oil. The company's product range includes an array of natural isolates and essential oils, Citral Ex Lemongrass, Natural Patchouli Oil, Rose Indian Oil, and Tea Tree Oil. The company has SO 22000:2005, ISO 9001:2008, HACCP, GMP certifications for Food and Pharma, and Kosher Certifications and serves markets such as cosmetic and personal care, food and beverage and pharmaceutical.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Alpha Chemika, founded in 1989 and based in Mumbai, India, is a manufacturer, supplier of laboratory reagents and fine chemicals. Their products are used in multiple industries, including pharmaceutical, chemical, biotechnology, and environmental. Their product portfolio ranges from chemicals such as Silver Nitrate, Perchloric Acid, and Lanthanum Acetate to laboratory tools and equipment such as Air Inlet Tubes, Air Inlet Tubes, and Optical Components. Alpha Chemika has been able to obtain ISO 9001:2000 certification.
Clean Science and Technology Limited, founded in India in 2006, is a manufacturer of specialty chemicals. The company offers 3 major segments including Performance Chemicals, Pharmaceutical Chemicals, and FMCG Chemicals. They are an essential ingredient in daily usage products catering to agricultural, cosmetic, aromas, and food industries. it has 3 manufacturing facilities and offers and also offers custom chemical formulations tailored to specific requirements. The company serves industries including chemical manufacturing, pharmaceutical and agriculture.
Westman Chemicals Pvt. Ltd. was founded in 1988 and is headquartered in Mulund West, Mumbai, as a manufacturer of industrial fine chemicals. The company has consistently upheld high standards of quality across its whole range of products, surpassing the expectations of its global clientele. Additionally, the facility possesses a comprehensive and contemporary laboratory that facilitates rigorous quality testing. All products produced by the organization are developed internally by its devoted research and development department. The organization consistently endeavors to improve client satisfaction by diligently adhering to its defined quality standards.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Hridaan Pharma Chem is a manufacturer of organic solvents, inorganic chemicals, and specialty chemicals, established in 2002 and headquartered in Mumbai, India. Their product range includes organic solvents such as methanol, ethanol, and isopropanol, inorganic chemicals such as sulfuric acid and nitric acid, and specialty chemicals such as flavoring agents and electronic chemicals. These products serve diverse industries with applications ranging from pharmaceuticals, plastics, and water treatment to food flavoring, fragrance, and electronics manufacturing. Hridaan Pharma Chem holds the Trust Seal Verified, indicating that the company has been authenticated and verified by IndiaMART.
Manas Petro Chem, founded in Mumbai, Maharashtra, in 2000 is a manufacturer and supplier of Chemical solvents for Pharmaceuticals & Other Industries. The company's product portfolio includes industrial chemicals such as Cyclohexane, Ethyl Aetate, Isopropyl Acetate, Methylene Dichloride and Pharmaceutical Chemicals. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. They also offer custom packaging, warehousing, and global distribution services.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Shree Sadguru Enterprise, established in 1995 and headquartered in Ankleshwar, Gujarat, India, is a manufacturer and supplier of chemical products and solutions. The company specializes in providing basic raw materials, pharma raw materials, and specialty chemicals. These products find applications in various industries, including pharmaceuticals, chemicals, and manufacturing. The company adheres to quality standards and is certified by ISO 9001 and ISO 14001, ensuring quality management systems and environmental safety and responsibility.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Manus Aktteva Biopharma LLP |
66.7%
|
| 2 | Clean Science and Technology Limited |
33.3%
|
Derivation Method
The ranking is calculated based on the click share within the anisol page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
7 | 87.5% |
|
Japan
|
1 | 12.5% |
