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This section provides an overview for butanediol as well as their applications and principles. Also, please take a look at the list of 10 butanediol manufacturers and their company rankings. Here are the top-ranked butanediol companies as of December, 2024: 1.Henan GP Chemicals Co.,Ltd, 2.Starsky international holdings Co., Ltd., 3.jincan Biotechology Co., Ltd..
Table of Contents
Butanediol is a divalent alcohol whose molecular formula is C4H10O2.
In addition to the widely used 1,4-butanediol, there are four other isomers of butanediol: 1,2-butanediol, 1,3-butanediol, and 2,3-butanediol.
1,4-butanediol is classified as "acute toxicity (oral)" in the GHS classification.
The uses of butanediol vary with each isomer, and all isomers are widely used in industry.
Typical applications for each isomer include 1,2-butanediol as a raw material for resins and amino acids, and 1,3-butanediol as a solvent, raw material for resins, and cosmetic additive. 1,4-butanediol can be used as a raw material for resins and solvents, and 2,3-butanediol as a raw material for pharmaceuticals and cosmetics.
In particular, 1,4-butanediol is an industrially important compound, as it is a raw material for tetrahydrofuran and γ-butyrolactone, which are widely used solvents in general.
1,2-butanediol has a melting point of -50°C, a boiling point of 195-196.9°C, and a density of 1.0023 g/cm3. 1,3-butanediol acts as a hypoglycemic agent for organisms and is converted to beta-hydroxybutyrate, which acts as a substrate for brain metabolism.
1,4-butanediol has a melting point of 20°C, a boiling point of 230°C, and a density of 1.010 g/cm3. In the body, 1,4-butanediol is metabolized to gamma-hydroxybutyrate. 2,3-butanediol has a melting point of 7.6°C, a boiling point of about 180°C, and a density of 1.000 to 1.010 g/cm3.
Butanediol is n-butane with two hydroxyl groups. Its molecular formula is C4H10O2 with a molar mass of 90.12 g/mol. 1,1-butanediol, for example, is unstable and quickly dehydrates to butyraldehyde.
In 1,2-butanediol, the carbon at position 2 is the chiral center. It is optically active, and there are two mirror isomers, (R)-1,2-butanediol and (S)-1,2-butanediol. Similarly, 1,3-butanediol has mirror-image isomers. And 2,3-butanediol has three stereoisomers: (2R,3R)-(-)-2,3-butanediol, (2S,3S)-(+)-2,3-butanediol and meso-2,3-butanediol.
1,4-butanediol is widely synthesized by hydrogenation of 1,4-butanediol obtained by the Reppe reaction of acetylene and formaldehyde.
1,4-butanediol can also be synthesized by hydrogenation after the conversion of anhydrides such as succinic acid and maleic acid to methyl esters.
1,4-butanediol is a raw material for plastics and fibers such as polybutylene terephthalate. 1,4-butanediol reacts with terephthalic acid to produce polybutylene terephthalate.
As an engineering plastic, polybutylene terephthalate has excellent thermal stability, electrical properties, and dimensional accuracy, and is widely used in automotive and electrical and electronic components.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Mitsubishi Chemical Corporation was founded in 1933 and has a head office in Tokyo, Japan. Mitsubishi Chemical Corporation provides products including chemicals, industrial gases, and health care products to customers globally. Mitsubishi Chemical Group’s performance products division manufactures and distributes. functional food materials, electronic and electrical components, specialty chemicals, and other products. Mitsubishi Chemical health care products include pharmaceuticals, drug discovery solutions, diagnostic reagents, and instruments for medical use. Mitsubishi Chemical Corporation also provides other services such as engineering, information systems, logistics, and consulting.
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd, established in 2013 and headquartered in Hefei City, China, is a manufacturer specializing in both standard and custom chemical synthesis. With manufacturing facilities in Anhui, Jiangsu, Zhejiang, and Inner Mongolia, Home Sunshine Pharma offers a range of products, including active pharmaceutical ingredients (APIs), intermediates, fine chemicals, coenzymes, and nucleotides. As an ISO 9001:2015 certified company, Home Sunshine Pharma serves research institutions, universities, and industries in Europe, America, and Southeast Asia with their chemical products.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
BASF Corporation, established in 1986 as the North American affiliate of BASF SE, is a manufacturer of chemical products, headquarters in Florham Park, New Jersey. The company operates 11 divisions which specialize in six business segments, namely chemicals, materials (such as plastics and rubber), industrial solutions, surface technologies (including construction chemicals and coating solutions), nutrition (for human and animal), and agricultural solutions. BASF's products find extensive applications across diverse industries such as automotive and transportation, construction, consumer electronics, energy, and furniture. Additionally, the company serves the medical and pharmaceuticals, paints and coatings, power tools, pulp and paper, as well as textile industries.
LyondellBasell, formally established in 2009, is a global manufacturer of raw chemicals, polymers, and fuels, with regional headquarters in the USA, the UK, Hong Kong, and the Netherlands. The company's products include basic chemicals, plastic resins, and advanced chemical composites, which are used across various industries such as sports and leisure, infrastructure, packaging, agriculture, and automotive. As one of the largest plastics, chemicals, and refining companies in the world, LyondellBasell's custom solutions range from client-specific product design and production to full plant design and start-up services.
Starsky international holdings Co., Ltd., established in 1984 and headquartered in Shanghai, China, is a manufacturer of organic and inorganic chemicals. The company provides APIs, organic and inorganic chemicals, food additives, fragrances and catalysts with customized service based on customers’ demands. It has two production facilities and complies with quality standards including ISO 9001 and 14001, GMP and Kosher. With independent export rights, the company exports its products to over 100 countries including USA, England, France, Germany and Thailand.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Henan GP Chemicals Co., Ltd., established in 2014 with its head office in Zhengzhou and a secondary office in Henan, China, is a distributor of chemical products from China. The company offers over 1,000 products, including chlorinated paraffin, isobutyl isobutyrate, and trioctyl trimellitate. Henan GP Chemicals Co., Ltd.'s main products are used in solvents, plastics and rubber, adhesives, pharmaceuticals, and agriculture. The company also provides custom services that include business-to-business distribution solutions for industrial and specialty chemicals around the world.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Henan GP Chemicals Co.,Ltd |
23.1%
|
| 2 | Starsky international holdings Co., Ltd. |
19.2%
|
| 3 | jincan Biotechology Co., Ltd. |
11.5%
|
| 4 | Hefei Home Sunshine Pharmaceutical Technology Co., Ltd. |
11.5%
|
| 5 | MilliporeSigma |
11.5%
|
| 6 | KANTO CHEMICAL CO.,INC. |
7.7%
|
| 7 | Mitsubishi Chemical Corporation |
7.7%
|
| 8 | Central Drug House |
3.8%
|
| 9 | LyondellBasell Industries |
3.8%
|
Derivation Method
The ranking is calculated based on the click share within the butanediol page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
2 | 50.0% |
|
China
|
1 | 25.0% |
|
India
|
1 | 25.0% |
