All Categories
History
This section provides an overview for pyrrolidine as well as their applications and principles. Also, please take a look at the list of 15 pyrrolidine manufacturers and their company rankings. Here are the top-ranked pyrrolidine companies as of December, 2024: 1.Junsei Chemical Co.,Ltd., 2.Mu Lei, 3.Kishida Chemical Co.,Ltd..
Table of Contents
Pyrrolidine, a heterocyclic amine with the formula C4H9N, also known as tetrahydro-1H-pyrrol, is found in various natural sources like carrots and tobacco leaves. It's recognized for its use in organic synthesis and medicinal applications due to its strong basicity and unique 5-membered ring structure.
Its primary applications include the synthesis of enamines from ketones, serving as a basic solvent in reactions, and forming the structural backbone of several pharmaceuticals, such as bepridil for cardiovascular conditions. Pyrrolidine derivatives are crucial in a wide range of organic compounds and medicines.
This colorless liquid displays a pungent odor, with a melting point of −63°C, a boiling point of 87°C, and exhibits high solubility in organic solvents. Its basic nature is characterized by a pKa of 11.27, making it a significant compound in chemical reactions and synthesis.
Industrially, it's produced from 1,4-butanediol and ammonia using metal oxide catalysts. Laboratory synthesis often involves reacting 4-chlorobutan-1-amine with a strong base, leading to various pyrrolidine derivatives through cascade reactions.
As a basic cyclic amine, pyrrolidine is utilized to form enamines through the Stork Enamine Reaction, facilitating the synthesis of complex organic molecules, including alkylated ketones and aldehydes.
Pyrrolidine is integral to the structure of many alkaloids and amino acids, such as nicotine, which combines a pyridine and pyrrolidine ring, and proline, highlighting its importance in both synthetic and natural chemistry.
*Including some distributors, etc.
Sort by Features
Sort by Area
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
A.B. Enterprises was established in 1984 and is headquartered in Maharashtra, India. The company is a manufacturer and supplier of general chemicals, specialties, and industrial chemicals to a broad range of industries including food, textile, plastic, rubber, and other industries. The company exports primarily to Canada, Bahrain, and Dubai. The company’s five major product segments include petrochemicals, food chemicals, laboratory chemicals, water treatment chemicals, and fine chemicals. In addition, the company manufactures dentistry materials, pesticides, and chemical supplies.
Alpha Chemika, founded in 1989 and based in Mumbai, India, is a manufacturer, supplier of laboratory reagents and fine chemicals. Their products are used in multiple industries, including pharmaceutical, chemical, biotechnology, and environmental. Their product portfolio ranges from chemicals such as Silver Nitrate, Perchloric Acid, and Lanthanum Acetate to laboratory tools and equipment such as Air Inlet Tubes, Air Inlet Tubes, and Optical Components. Alpha Chemika has been able to obtain ISO 9001:2000 certification.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Hridaan Pharma Chem is a manufacturer of organic solvents, inorganic chemicals, and specialty chemicals, established in 2002 and headquartered in Mumbai, India. Their product range includes organic solvents such as methanol, ethanol, and isopropanol, inorganic chemicals such as sulfuric acid and nitric acid, and specialty chemicals such as flavoring agents and electronic chemicals. These products serve diverse industries with applications ranging from pharmaceuticals, plastics, and water treatment to food flavoring, fragrance, and electronics manufacturing. Hridaan Pharma Chem holds the Trust Seal Verified, indicating that the company has been authenticated and verified by IndiaMART.
BASF SE, a manufacturer of polyurethane solutions, has been in business since 1865 and is headquartered in Ludwigshafen, Germany. They offer polyurethane products such as polyester polyols for CASE and footwear applications. The company delivers cutting-edge products while prioritizing environmental sustainability. With decades of expertise, they continue to drive creativity in the polyurethane sector, meeting the evolving needs of customers worldwide. With a long-standing history of success, BASF SE remains engaged on advancing technology and shaping the future of polyurethane applications.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Vizag Chemical International was founded in Andhra Pradesh, India, in 2011. Vizag Chemical International sells chemical-based products for many sectors including automotive, agriculture, airline, deodorizers, construction chemicals, boat maintenance, degreasers, detergents, drain clean products, greases, personal hygiene, lab chemicals and equipment, fuel treatment, metal treatment, tank cleaners, swimming pool and spa chemicals, scale removers, sewage chemical treatment, as well as raw chemicals. Vizag Chemical International also provides a range of services including chemical inspection, logistics, chemical usage supervision, as well as tank cleaning.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Junsei Chemical Co.,Ltd. |
30.8%
|
| 2 | Mu Lei |
23.1%
|
| 3 | Merck |
23.1%
|
| 4 | Kishida Chemical Co.,Ltd. |
15.4%
|
| 5 | KANTO CHEMICAL CO.,INC. |
7.7%
|
Derivation Method
The ranking is calculated based on the click share within the pyrrolidine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
6 | 54.5% |
|
Japan
|
4 | 36.4% |
China
|
1 | 9.1% |
