8 Nitroaniline Manufacturers in 2024
This section provides an overview for nitroaniline as well as their applications and principles. Also, please take a look at the list of 8 nitroaniline manufacturers and their company rankings. Here are the top-ranked nitroaniline companies as of November, 2024: 1.Oakwood Products, Inc.
Table of Contents
What Is Nitroaniline?
Nitroaniline is an organic compound belonging to the aromatic amine family, in which one hydrogen atom on the aromatic ring of aniline is replaced by a nitro group.
The chemical formula is C6H6N2O2, with a molecular weight of 138.126. There are three isomers, depending on the position of the nitro group: 2-Nitroaniline (o-Nitroaniline), 4-Nitroaniline (p-Nitroaniline), and 3-Nitroaniline (m-Nitroaniline).
Generally, 4-nitroaniline is the most widely used, with CAS registration numbers 88-74-4 (2-nitroaniline), 99-09-2 (3-nitroaniline), and 100-01-6 (4-nitroaniline).
Uses of Nitroaniline
Nitroaniline is primarily used as an intermediate in the synthesis of dyes, pharmaceuticals, antioxidants, gasoline gum inhibitors, poultry medications, and corrosion inhibitors. 4-nitroaniline serves as a raw material for the synthesis of the red azo dye, Para Red.
Para Red, developed in 1880, was the world's first azo dye and remains significant for its easy coloring, deep coloration, and excellent light and heat resistance.
3-Nitroaniline is used as a synthetic intermediate, especially for azo dyes, from which yellow and blue dyes are synthesized.
Properties of Nitroaniline
1. Basic Information on 2-Nitroaniline
2-nitroaniline, an orange crystal at room temperature, has a melting point of 71-72°C and a boiling point of 284°C. It is slightly soluble in ethanol and diethyl ether, and very insoluble in water.
2. Basic Information on 3-Nitroaniline
3-nitroaniline, a yellow crystal at room temperature, has a melting point of 114°C and a boiling point of 306°C. It is slightly soluble in ethanol and diethyl ether, and very insoluble in water.
3. Basic Information on 4-Nitroaniline
4-nitroaniline, the most versatile of the three isomers, appears as a yellow or yellowish-red powder or crystal at room temperature. It has a melting point of 148°C, a boiling point of 332°C, and a density of 1.437 g/mL. It is slightly soluble in ethanol and diethyl ether, and very insoluble in water.
Types of Nitroaniline
Nitroaniline is commonly sold as a reagent for research and development purposes, with 4-nitroaniline being the most common, followed by 2-nitroaniline and 3-nitroaniline. Available volumes include 25 g, 500 g, and other manageable sizes for laboratory use, typically stored at room temperature.
Other Information on Nitroaniline
1. Synthesis of Nitroaniline
4-nitroaniline and 2-nitroaniline can be synthesized from aniline through the following steps:
- Protection of the amino group of aniline with an acetyl group (to produce acetanilide).
- Nitration of the resulting acetanilide with mixed acid (aromatic nucleophilic substitution reaction).
- Purification and separation of 2-nitroacetanilide and 4-nitroacetanilide.
- Deprotection of the acetyl group through hydrolysis.
Due to the ortho-para directing nature of these reactions, 3-nitroaniline cannot be synthesized by this method but can be produced through the nitration of benzamides followed by a Hofmann rearrangement.
2. Chemistry of 4-Nitroaniline
A notable chemical reaction involving 4-nitroaniline is the synthesis of the azo dye Para Red, which is achieved by diazotization of 4-nitroaniline followed by coupling with β-naphthol. For dyeing, the fiber is immersed in an aqueous alkaline solution of β-naphthol before the coupling reaction is conducted on the fiber.
List of 8 Nitroaniline Manufacturers
*Including some distributors, etc.
Sort by Features
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- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- Japan
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Oakwood Products, Inc
2-Nitroaniline
Manufacturer Overview
Oakwood Chemical is based in Estill, South Carolina. The company is a producer of a wide range of organics with particular emphasis on fluorine and sulfur compounds. The company also offers custom synthesis services and bulk quantities upon request. The company has independent operations and operations in collaboration with the University of South Carolina. The company’s suppliers include ChemCollect, Chess, KISHIDA CHEMICAL Co., Ltd., and Tetramer. The company’s featured products include boronic acids and esters, peptide coupling, fluorinated amines, and reagents for synthesis.
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Cambridge Isotope Laboratories, Inc.
4-NITROANILINE
Manufacturer Overview
Cambridge Isotope Laboratories (CIL) established in 1981, is a global supplier of stable isotopes and labeled compounds, headquartered in the United States. The company provides of products for research, environmental analysis, and medical applications.Their comprehensive product offerings include isotopically labeled standards, biochemicals, and gases, catering to many industries and scientific communities, with partnerships worldwide. They specializes in the process of labeling biochemical and organic compounds with highly enriched, stable (nonradioactive) isotopes of carbon, hydrogen, nitrogen and oxygen.
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BioVision Inc.
pNA (p-nitroaniline)
Company Overview
BioVision Inc., established in 1999 and based in Waltham, Massachusetts, is a manufacturer and supplier of life science research products. The company is a part of the Abcam company. The company provides various biochemicals, assay kits, and research reagents. These products are used in research fields such as autophagy, cell damage and oxidative stress, food science, signal transduction, and drug metabolism and disposition. Its products are essential tools for scientists and researchers worldwide, aiding in advancing medical and biological sciences. The company adheres to ISO 13485 standards, ensuring its quality management systems in producing research products for life sciences.
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KANTO CHEMICAL CO.,INC.
4-Nitroaniline
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Spectracer LLC
p-Nitroaniline TS
Manufacturer Overview
SPECTRACER USA, established in 1999 and based in Los Angeles, California, United States, is a manufacturer of custom reference materials, analytical reagents, and pharmacopeia. The solutions produced by the company are manufactured in a clean room to avoid contamination, and accuracy is attained through traceability to NIST standards. All the certified reference materials and reagents are produced meeting the ISO 9001 quality management system, ISO/IEC 17025, and ISO/IEC 17034 standards. There is an automated computed aided manufacture (CAM) system with Spectracer to prepare custom-made multi and single-component standards.
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MilliporeSigma
4-Nitroaniline
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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nacalai
p-Nitroaniline
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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Lab Pro Inc.
4-Nitroaniline
Company Overview
Lab Pro Inc. (LP) is an American manufacturer and distributor of laboratory equipment and supplies that was established in Sunnyvale, California in 1979. The company produces various chemical products including reagents, oxidizers, and acids, as well as personal protective equipment (PPE), microscopes, and laboratory hand tools. It also offers laboratory instrumentation and utensils such as refractometers, forceps, and pH meters. Aside from its products, LP also provides vendor-managed inventory and lab chiller leasing services for its clients in industrial research facilities, academic institutions, and R&D testing laboratories.
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Nitroaniline Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Oakwood Products, Inc |
100.0%
|
Derivation Method
The ranking is calculated based on the click share within the nitroaniline page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
Newly Established Company
- Spectracer LLC: 1999 (25 years ago)
- Cambridge Isotope Laboratories, Inc.: 1981 (43 years ago)
- Lab Pro Inc.: 1979 (45 years ago)
Company with a History
- nacalai: 1934 (90 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Lab Pro Inc.: 1979 (45 years ago)
Nitroaniline Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Nitroaniline Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
United States of America
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3 | 60.0% |
Japan
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2 | 40.0% |
