All Categories
History
This section provides an overview for nitroacetanilide as well as their applications and principles. Also, please take a look at the list of 11 nitroacetanilide manufacturers and their company rankings.
Table of Contents
Nitroacetanilide is a nitro derivative of acetanilide with the chemical formula C8H8N2O3.
There are three positional isomers, 2-nitroacetanilide (o-nitroacetanilide), 3-nitroacetanilide (m-nitroacetanilide), and 4-nitroacetanilide (p-nitroacetanilide), depending on the substitution position of the nitro group.
The molecular weight is 180.16, and all three isomers exist in a solid state at room temperature.
The main uses of nitroacetanilide are as a raw material for organic synthesis and as an intermediate in organic synthesis.
For example, in the synthesis of 4-nitroaniline, the amino group of aniline is protected to make acetanilide, and then 4-nitroacetanilide is used as an intermediate in the nitration reaction. This is because direct nitration of aniline leads to decomposition by oxidation and orientation changes due to the formation of anilinium salts.
4-nitroaniline is a useful compound with a variety of industrial applications, such as an intermediate in the synthesis of dyes and pharmaceuticals, an antioxidant, and an anti-gumming agent in gasoline.
2-nitroacetanilide (o-nitroacetanilide) has a melting point of 93°C and is a pale yellow or brown crystalline powder at room temperature. The CAS registration number is 552-32-9.
The CAS registration number is 552-32-9. It should be kept away from high temperatures and direct sunlight during storage, as it may be altered by light. It also reacts with strong oxidizing agents, and therefore, mixing should be avoided.
3-nitroacetanilide (m-nitroacetanilide) has a nitro group attached at the meta (3-position) from the amide group. The melting point is 151-154°C. It is a light yellow to yellowish brown crystalline powder at room temperature.
The CAS registration number is 122-28-1. It should be kept away from high temperatures and direct sunlight during storage, as it can be altered by light. It also reacts with strong oxidizing agents, and therefore, mixing should be avoided.
4-Nitroacetanilide (p-nitroacetanilide) has a nitro group attached at the para (4-position) from the amide group. It is a yellow to yellowish-brown crystalline powder with a melting point of 213-216℃. It is soluble in ethanol and acetone, but insoluble in water.
The CAS registration number is 104-04-1. It should be kept away from high temperatures and direct sunlight during storage, as it may be altered by light. It also reacts with strong oxidizing agents, and therefore, mixing should be avoided.
Nitroacetanilide, as mentioned above, has three different positional isomers, all of which are commercially available as reagent products for research and development. The types of volumes include 25g, 100g, etc. They are sold as reagent products that can be handled at room temperature.
Other related derivatives marketed include 2'-methyl-4'-nitroacetanilide, 4'-fluoro-2'-nitroacetanilide, and 4-acetoxy-1-acetylamino-2-nitrobenzene.
2-nitroacetanilide and 4-nitroacetanilide can be obtained by the following process.
The aromatic nucleophilic substitution reaction in 2 is ortho-para oriented, especially favoring the para position. Therefore, this reaction produces 4-nitroacetanilide as the main product and 2-nitroacetanilide as a byproduct; to synthesize 3-nitroacetanilide, another synthetic route is used.
*Including some distributors, etc.
Sort by Features
Sort by Area
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Capot Chemical Co.,Ltd was established in 1996 and is a manufacturer of custom synthesis products based in Hanghzhou, P.R. China. The company manufactures various organics products such as boronic acids, unnatural amino acids, cross linkers, chiral building blocks, and heterocyclic compounds. The management of the company have obtained the ISO 9001:2015 standards certification for the safety management system. The company have participated in various exhibitions, such as Chemspec Europe in Basel and CPhI in Barcelona, Shanghai, Milan, and Philadelphia.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
ALPHA CHEMICA, established in 1985, is an Indian manufacturer and supplier of laboratory reagents and fine chemicals, headquartered in Mumbai, Maharashtra. Their wide range of products includes high-performance liquid chromatography (HPLC), analytical reagent/guaranteed reagent (AR/GR), laboratory reagents (LRs), and fine chemicals, catering to life science and other specialty research. During the COVID-19 pandemic and its aftermath, ALPHA CHEMICA offered BactGO, a disinfectant solution with stabilized hydrogen peroxide using silver-based chemistry, and BaVi-X, a 75% alcohol-based hand sanitizer.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Pharmachem Research & Development Laboratories, founded in 1998 and situated in Maharashtra, India, functions as a manufacturer and supplier of Laboratory & Fine Chemicals. Among its offerings are Thiomalic acid, Chloranilic acid, Para Bromo Phenol, Homidium bromide, and Safranine. Additionally, it provides basic drugs such as Hydroxy Urea, Cyclophosphamide, and Camylofine Dihydrocloride. The company boasts modern infrastructure spanning a spacious land area of 1000 square feet, well-equipped with a variety of tools, chemicals, and facilities to support research activities.
AB Enterprises, founded in 1984 and located in Mumbai, India, is a manufacturer, distributor, and supplier of chemicals and raw materials for various industries. Their product range includes industrial chemicals, solvents, pharmaceutical ingredients, and specialty materials. These products cater to industries such as pharmaceuticals, agrochemicals, paints and coatings, beauty, and the textile industry. In addition, they also offer different categories of chemicals, including biocide chemicals, brass handicraft chemicals, and corrugated paper gum, which are used as raw materials, additives, or ingredients in manufacturing processes.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
3 | 42.9% |
|
Japan
|
2 | 28.6% |
|
United States of America
|
1 | 14.3% |
|
China
|
1 | 14.3% |
