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This section provides an overview for acetanilide as well as their applications and principles. Also, please take a look at the list of 13 acetanilide manufacturers and their company rankings. Here are the top-ranked acetanilide companies as of December, 2024: 1.PerkinElmer Inc., 2.Chem Service, Inc., 3.SAE Manufacturing Specialties Corp.
Table of Contents
Acetanilide is an organic compound with chemical formula C8H9NO and specific formula C6H5NHCOCH3. Its IUPAC nomenclature is N-phenylacetamide, and other names include N-acetylaniline, N-acetylbenzeneamine, acetenyl, etc.
Its CAS number is 103-84-4. It has a molecular weight of 135.16, a melting point of 114-117°C, and a boiling point of 304-305°C. At room temperature, it is a white powder or plate-like crystal. It has a peculiar odor similar to that of esters. Its density is 1.219 g/cm3. It is soluble in diethyl ether, benzene, and toluene, and soluble in ethanol and acetone.
It is not soluble in water because the molecule is not highly polar, and its solubility in water is 5.2 g/kg (at 20°C). However, it is soluble in hot water.
The main uses of acetanilide are as a synthetic raw material in the synthesis of various organic compounds such as dyes, pharmaceuticals, dyestuffs, and fibers.
It is also used as a stabilizer for hydrogen peroxide and as a rubber vulcanization accelerator. It is also used as an azo pigment in toners.
As a pharmaceutical raw material, it is especially used as a raw material for 4-acetamidobenzenesulfonyl azide, an intermediate in sulfa drugs. Acetanilide is also known for its antipyretic and analgesic properties as a member of the same family of drugs as acetaminophen. It was once marketed as a mass-market drug and was known as antifebrin.
In addition to ordinary organic synthesis, they are sometimes used in affinity capillary electrophoresis studies of drug-protein binding. It is sometimes used as a standard in elemental analysis, in which case a dedicated high-purity product is used.
However, it is not widely used today because many cases of methemoglobinemia causing liver and kidney damage and toxic effects such as blood cell destruction and convulsions have been observed. It has been replaced by less toxic compounds such as acetaminophen.
Acetanilide is a stable compound in air, but reacts violently with strong oxidizers and strong bases. Therefore, acetanilide should be stored away from strong oxidizers and strong bases. Its flash point is 161°C, and it is believed to ignite when heated to 545°C.
Acetanilide is sold mainly as a reagent product for research and development. It is available in 1g, 5g, 100g, 500g, and 1kg volumes and can be handled at room temperature.
Acetanilide is synthesized by acetylation of aniline. The main acetylating agent is acetic anhydride, but anilinium salts and acetyl chloride can also be used.
The synthesis of acetanilide with aniline and acetic anhydride is a very typical reaction for the formation of amides and is therefore often discussed on the study.
Nitration of acetanilide yields nitroacetanilide. This reaction is an ortho- and para-oriented aromatic nucleophilic substitution reaction, yielding 2-nitroacetanilide and 4-nitroacetanilide. Of these, 4-nitroacetanilide is particularly used as a raw material for dyes.
Note that 2-nitroacetanilide and 4-nitroacetanilide can be treated with acid to remove the acetyl group, giving 2-nitroaniline and 4-nitroaniline, respectively.
Reports also suggest that when acetanilide is used as a drug, acetaminophen is produced in the body as a metabolite of acetanilide.
*Including some distributors, etc.
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PerkinElmer Inc., founded in 1937, is an American manufacturer headquartered in Waltham, Massachusetts, specializing in laboratory technology and management. The company's product offerings include analysis and characterization instruments, software, and consumables. Such offerings cover chromatography, mass spectrometry, molecular and atomic spectroscopy. They also provide immunoassay and food quality analyzers, as well as the simultaneous thermal analyzer (STA). These products find applications in various industries, such as biopharmaceuticals, food safety, lithium battery, and water resource management. PerkinElmer also offers OneSource Laboratory Services, providing knowledge, application, and service solutions for scientific laboratories. Additionally, their LABStartUp program supports new laboratories with instrumentation, consumables, and funding.
Based in Bayville, NY, SAE Manufacturing Specialties Corp. is an ISO-certified supplier and manufacturer of industrial equipment, chemicals, components, ordinance, electronics, and systems for industries ranging from aerospace to high tech to law enforcement. Examples of product offerings include raw materials, chemicals, and lubricants for industrial purposes to finished products such as security helmets for law enforcement, and military ordnances. SAE also provides research and development as well as technical support for other companies in similar industries.
Thermo Fisher Scientific Inc., founded in 1956 and headquartered in Waltham, Massachusetts, is a manufacturer and supplier of life science solutions, analytical instruments, specialty diagnostics, laboratory products, and biopharma services. Through its brand names, including Invitrogen, Fisher Scientific, Patheon, Applied Biosystems, and Gibco, among others, the company provides a wide range of products, which include chromatography systems, thermal cyclers, automated cell counters, fermenters, and DNA polymerases. The company’s annual revenue is over 40 billion USD, and it serves several fields, including customers working in clinical diagnostic labs, research institutions, hospitals, government agencies, and pharmaceutical/biotech companies.
EA Consumables is a supplier of industrial consumables for Elemental Microanalysis based in the United States and established in 1995. The company specializes in providing a range of industrial supplies, including abrasives, adhesives, safety equipment, and tools, catering to diverse industries such as manufacturing, construction, and automotive. It also has developed a team of craftsman and scientists ably developing, testing, and manufacturing a range of consumables for CHNOS and protein combustion analysis. The company has both ISO 9001 and ISO 17025, so both manufacturing and laboratory are certified.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Chem Service, Inc. is a certified ISO 9001:2015 and ISO/IEC 17025:2017 manufacturer and supplier of analytical standards and reagents for chemical analysis, founded in 1962 and is headquartered in West Chester, Pennsylvania. Their products cater to various industries, including pharmaceuticals, environmental testing, clinical testing, and forensic sciences. Chem Service offers a broad range of products, including certified reference materials, analytical reagents, and proficiency testing samples. Their products are used for quality control testing, method development, and calibration purposes.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Reagents, established in 1997 and headquartered in New York, USA, is a manufacturer and distributor of laboratory chemicals and reagents. Serving academic institutions, research laboratories, pharmaceutical companies, and other industries, the company offers a diverse range of products that encompass organic and inorganic chemicals used in pharmaceuticals, plastics, water treatment, and more. They provide biological stains and indicators for laboratory applications like cell culture and DNA analysis, along with culture media ingredients for microbial growth. Their product portfolio also caters to applications in batteries, pigments, and catalysts. Reagents' comprehensive offerings support education, research, and manufacturing processes across various sectors.
VWR International, LLC is a significant supplier of laboratory equipment and chemicals. Established in 1852, the company operates from its headquarters in Radnor, Pennsylvania, United States of America. VWR International, LLC offers an array of laboratory essentials, including scientific instruments, chemicals, and consumables. Its products support diverse industries such as biopharma, healthcare, education and government, advanced technologies and applied materials industries. The company's services encompass equipment maintenance, VWR custom canufacturing services, calibration, and technical assistance, catering to the needs of laboratories across various sectors.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ward's Science, founded in 1996 with headquarters in the USA, is a supplier of science education materials for schools and educators across the USA. The company's products include a wide range of classroom study materials, laboratory equipment, distance learning tools, and microscopes. Ward's Science study materials cover topics including science, math, biology, and chemistry. The company also provides custom study kit solutions for geology, teachers, and students, as well as services to assist in applying for grants and science funding.
Barentz was founded in Amsterdam in 1953 and expanded to Avon, Ohio where its American headquarters is today. Barentz is a specialty chemicals and ingredients distributor that, with the acquisition of Maroon Group in December 2020, has a global reach in distributing chemicals to life sciences and broader specialty chemical industries. Barentz has seven product divisions including nutrition, plastics, cleaning products, pharmaceuticals, and personal care. Within these, the company distributes, various chemical additives, intermediates, minerals, and odor counteractant compounds.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | PerkinElmer Inc. |
42.3%
|
| 2 | Chem Service, Inc. |
7.7%
|
| 3 | SAE Manufacturing Specialties Corp |
7.7%
|
| 4 | Kishida Chemical Co.,Ltd. |
7.7%
|
| 5 | VWR International, LLC |
5.8%
|
| 6 | Toronto Research Chemicals |
5.8%
|
| 7 | MilliporeSigma |
5.8%
|
| 8 | Barentz US |
3.8%
|
| 9 | Reagents |
3.8%
|
| 10 | Thermo Fisher Scientific Inc. |
3.8%
|
Derivation Method
The ranking is calculated based on the click share within the acetanilide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 50.0% |
|
Japan
|
1 | 12.5% |
|
Canada
|
1 | 12.5% |
|
Ireland
|
1 | 12.5% |
|
United Kingdom
|
1 | 12.5% |
